Enhanced apoptosis, oxidative stress and mitochondrial dysfunction in lymphocytes as potential biomarkers for Alzheimer's disease (Q36993185)

17 August 2017

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title

Enhanced apoptosis, oxidative stress and mitochondrial dysfunction in lymphocytes as potential biomarkers for Alzheimer's disease (English)

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17 August 2017

Enhanced apoptosis, oxidative stress and mitochondrial dysfunction in lymphocytes as potential biomarkers for Alzheimer’s disease (English)

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A. Eckert

8

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author name string

Leuner K

1

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17 August 2017

Pantel J

2

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17 August 2017

Frey C

3

1 reference

17 August 2017

Schindowski K

4

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17 August 2017

Schulz K

5

1 reference

17 August 2017

Wegat T

6

1 reference

17 August 2017

Maurer K

7

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17 August 2017

Eckert A

8

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17 August 2017

Müller WE

9

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17 August 2017

K. Leuner

1

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J. Pantel

2

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C. Frey

3

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K. Schindowski

4

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K. Schulz

5

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T. Wegat

6

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K. Maurer

7

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W. E. Müller

9

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publication date

1 January 2007

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Journal of neural transmission. Supplementum

17 August 2017

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17 August 2017

207-215

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17 August 2017

72

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Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implication

17 August 2017

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

The expression of key oxidative stress-handling genes in different brain regions in Alzheimer's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Energetics in the pathogenesis of neurodegenerative diseases

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

The role of the metabolic lesion in Alzheimer's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Predicting Alzheimer dementia in mild cognitive impairment patients. Are biomarkers useful?

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Mitochondrial abnormalities in Alzheimer brain: mechanistic implications

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Cytochrome c oxidase is decreased in Alzheimer's disease platelets

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Cholinesterase inhibitor rivastigmine enhance the mitochondrial electron transport chain in lymphocytes of patients with Alzheimer's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer's patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Gluthatione level is altered in lymphoblasts from patients with familial Alzheimer's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Molecular insights into mechanisms of the cell death program: role in the progression of neurodegenerative disorders

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Oxidative stress and overexpression of manganese superoxide dismutase in patients with Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Age-associated changes in mitochondrial parameters on peripheral human lymphocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Lymphocytes as cell model to study apoptosis in Alzheimer's disease: vulnerability to programmed cell death appears to be altered.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Elevated levels of fragmented DNA nucleosomes in native and activated lymphocytes indicate an enhanced sensitivity to apoptosis in sporadic Alzheimer's disease. Specific differences to vascular dementia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Mitochondrial dysfunction, apoptotic cell death, and Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Differential diagnosis and clinical assessment of patients with severe Alzheimer disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Apolipoprotein E epsilon 4 is associated with an increased vulnerability to cell death in Alzheimer's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

The predementia diagnosis of Alzheimer disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Mitochondrial abnormalities in Alzheimer's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Mitochondrial function in fibroblasts with aging in culture and/or Alzheimer's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Apolipoprotein E and Alzheimer disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Challenges in neuronal apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Detection of oxidative DNA damage in lymphocytes of patients with Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Systemic increase of oxidative nucleic acid damage in Parkinson's disease and multiple system atrophy

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Cytosolic phospholipase A2 mediates neuronal apoptosis induced by soluble oligomers of the amyloid-beta peptide

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Enhanced ROS-generation in lymphocytes from Alzheimer's patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporine-induced cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Association between APOE epsilon4 allele and increased expression of CD95 on T cells from patients with Alzheimer's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Decreased platelet cytochrome c oxidase activity is accompanied by increased blood lactate concentration during exercise in patients with Alzheimer disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Oxidative stress, perturbed calcium homeostasis, and immune dysfunction in Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Pathways towards and away from Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Searching for the role and the most suitable biomarkers of oxidative stress in Alzheimer's disease and in other neurodegenerative diseases.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Respiratory chain enzyme activities in isolated mitochondria of lymphocytes from patients with Alzheimer's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Elevated levels of oxidative DNA damage in lymphocytes from patients with Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Promotion of oxidative lipid membrane damage by amyloid beta proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Cytochrome oxidase deficiency in Alzheimer's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Electron transport chain defects in Alzheimer's disease brain.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Fluorescent light-induced chromatid breaks distinguish Alzheimer disease cells from normal cells in tissue culture

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Oxidative damage in Alzheimer's disease: the metabolic dimension

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Cytogenetic alterations in lymphocytes of Alzheimer's disease and Parkinson's disease patients.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Expression of mitochondrial genes and transcription estimation in different brain areas in Alzheimer's disease patients.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Impact of Aging: Sporadic, and Genetic Risk Factors on Vulnerability to Apoptosis in Alzheimer's Disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Apoptosis of CD4+ T and Natural Killer Cells in Alzheimer's Disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Impaired Cu/Zn-SOD activity contributes to increased oxidative damage in APP transgenic mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Aging sensitizes toward ROS formation and lipid peroxidation in PS1M146L transgenic mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

Oxidative imbalance and cathepsin D changes as peripheral blood biomarkers of Alzheimer disease: a pilot study.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

The magnitude of dementia occurrence in the world

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-211-73574-9_27

10.1007/978-3-211-73574-9_27

31 March 2020

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