Reactive oxygen species-dependent signaling regulates cancer (Q37560671)

21 August 2017

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title

Reactive oxygen species-dependent signaling regulates cancer (English)

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21 August 2017

reactive oxygen species

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Frank Weinberg

1

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PubMed ID

19629388

21 August 2017

Navdeep S Chandel

series ordinal

2

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21 August 2017

24 July 2009

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Cellular and Molecular Life Sciences

21 August 2017

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21 August 2017

66

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21 August 2017

3663-3673

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21 August 2017

23

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https://scigraph.springernature.com/pub.10.1007/s00018-009-0099-y

21 August 2017

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cites work

Free radicals in the physiological control of cell function

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https://api.crossref.org/works/10.1007%2FS00018-009-0099-Y

Role of ubiquinone in the mitochondrial generation of hydrogen peroxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0099-Y

Antioxidants prevent oxidative DNA damage and cellular transformation elicited by the over-expression of c-MYC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0099-Y

Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0099-Y

Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0099-Y

High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0099-Y

Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-009-0099-Y

Cell transformation by the superoxide-generating oxidase Mox1

21 January 2018

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12 December 2020

Misregulation of stromelysin-1 expression in mouse mammary tumor cells accompanies acquisition of stromelysin-1-dependent invasive properties

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12 December 2020

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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12 December 2020

Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma

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12 December 2020

Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis.

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12 December 2020

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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12 December 2020

Cells depleted of mitochondrial DNA (rho0) yield insight into physiological mechanisms

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12 December 2020

Production of large amounts of hydrogen peroxide by human tumor cells

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12 December 2020

Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

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12 December 2020

Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes

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12 December 2020

The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis

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12 December 2020

Involvement of growth factor receptors in the mammalian UVC response

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12 December 2020

Mitochondrial complex III regulates hypoxic activation of HIF.

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12 December 2020

Increased expression of activated matrix metalloproteinase-2 by human endothelial cells after sublethal H2O2 exposure

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12 December 2020

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation

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12 December 2020

ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis

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12 December 2020

Biology of hypoxia-inducible factor-2alpha in development and disease

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12 December 2020

Redox-regulation of Erk1/2-directed phosphatase by reactive oxygen species: role in signaling TPA-induced growth arrest in ML-1 cells

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12 December 2020

The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia

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12 December 2020

Reactive oxygen species in cell signaling

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12 December 2020

Measuring oxidative damage in humans: relation to cancer and ageing.

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12 December 2020

Detection and characterization of tumor hypoxia using pO2 histography

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12 December 2020

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

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12 December 2020

Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix

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12 December 2020

Activation of matrix metalloproteinase-2 by overexpression of manganese superoxide dismutase in human breast cancer MCF-7 cells involves reactive oxygen species

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12 December 2020

Regulation of the cell cycle machinery by oncogenic ras.

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12 December 2020

Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

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12 December 2020

Prooxidant states and tumor promotion

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12 December 2020

Identification of renox, an NAD(P)H oxidase in kidney

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12 December 2020

A conserved family of prolyl-4-hydroxylases that modify HIF

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12 December 2020

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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12 December 2020

Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space

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12 December 2020

Redox-dependent downregulation of Rho by Rac.

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12 December 2020

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

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12 December 2020

Reversible inactivation of the tumor suppressor PTEN by H2O2

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12 December 2020

Essential role of PDK1 in regulating cell size and development in mice

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12 December 2020

Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing superoxide dismutase

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12 December 2020

Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria

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12 December 2020

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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12 December 2020

Two vicinal cysteines confer a peculiar redox regulation to low molecular weight protein tyrosine phosphatase in response to platelet-derived growth factor receptor stimulation

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12 December 2020

Regulation of late G1/S phase transition and APC Cdh1 by reactive oxygen species

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12 December 2020

Hydrogen peroxide activates p70(S6k) signaling pathway

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12 December 2020

Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas

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12 December 2020

Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents

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12 December 2020

Hypoxic regulation of metastasis via hypoxia-inducible factors

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12 December 2020

Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells

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12 December 2020

Manganese superoxide dismutase modulates hypoxia-inducible factor-1 alpha induction via superoxide

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12 December 2020

PIK3CA is implicated as an oncogene in ovarian cancer.

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12 December 2020

Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway.

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12 December 2020

Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1

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12 December 2020

Myxothiazol induces H(2)O(2) production from mitochondrial respiratory chain

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12 December 2020

Roles of superoxide radical anion in signal transduction mediated by reversible regulation of protein-tyrosine phosphatase 1B

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12 December 2020

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation

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12 December 2020

Reactive oxygen species in tumor progression

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12 December 2020

Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.

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12 December 2020

Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells

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12 December 2020

The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-beta-catenin signalling through dishevelled

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12 December 2020

N-Ethylmaleimide inhibits platelet-derived growth factor BB-stimulated Akt phosphorylation via activation of protein phosphatase 2A.

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12 December 2020

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

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12 December 2020

Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo

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12 December 2020

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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12 December 2020

Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation.

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12 December 2020

The respiratory burst oxidase

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12 December 2020

Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

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12 December 2020

Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma

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12 December 2020

Redox regulation of cell survival

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12 December 2020

Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

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12 December 2020

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

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12 December 2020

Somatic mutations of the mitochondrial genome in human colorectal tumours

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12 December 2020

Targeting HIF-1 for cancer therapy

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12 December 2020

Induction of cyclin D1 overexpression by activated ras.

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12 December 2020

Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro

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12 December 2020

Intrinsic tumour suppression

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12 December 2020

Functional interaction between beta-catenin and FOXO in oxidative stress signaling

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12 December 2020

Architecture of succinate dehydrogenase and reactive oxygen species generation

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12 December 2020

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

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12 December 2020

Redox regulation of PI 3-kinase signalling via inactivation of PTEN

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12 December 2020

Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenance

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12 December 2020

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

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12 December 2020

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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12 December 2020

Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway

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12 December 2020

Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1

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12 December 2020

Targeting RAS signalling pathways in cancer therapy

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12 December 2020

Mitochondrial redox control of matrix metalloproteinases

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12 December 2020

Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements

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12 December 2020

Complex III releases superoxide to both sides of the inner mitochondrial membrane

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12 December 2020

Hypoxia, HIF1 and glucose metabolism in the solid tumour

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12 December 2020

Prevention of hypoxia by myoglobin expression in human tumor cells promotes differentiation and inhibits metastasis

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12 December 2020

Mitochondrial formation of reactive oxygen species

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12 December 2020

mtDNA mutations increase tumorigenicity in prostate cancer

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12 December 2020

Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity

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12 December 2020

Mutant K-rasV12 increases COX-2, peroxides and DNA damage in lung cells

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12 December 2020

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

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12 December 2020

Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol.

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12 December 2020

Expression and localization of NOX2 and NOX4 in primary human endothelial cells

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12 December 2020

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

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12 December 2020

Mitochondrial regulation of oxygen sensing

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12 December 2020

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

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12 December 2020

Nox4 as the major catalytic component of an endothelial NAD(P)H oxidase.

1 reference

12 December 2020

Metastasis: from dissemination to organ-specific colonization

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12 December 2020

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway

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12 December 2020

Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis

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12 December 2020

Mitochondrial tumour suppressors: a genetic and biochemical update

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12 December 2020

Protonmotive pathways and mechanisms in the cytochrome bc1 complex

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12 December 2020

The extracellular signal-regulated kinase pathway is required for activation-induced cell death of T cells

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12 December 2020

Biologically relevant metal ion-dependent hydroxyl radical generation. An update

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12 December 2020

Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases

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12 December 2020

Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

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12 December 2020

NOX enzymes and the biology of reactive oxygen

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12 December 2020

Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells

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12 December 2020

Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma

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12 December 2020

Distinct thresholds govern Myc's biological output in vivo

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12 December 2020

HIF-dependent antitumorigenic effect of antioxidants in vivo

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12 December 2020

Reactive oxygen generated by Nox1 triggers the angiogenic switch

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12 December 2020

E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination

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12 December 2020

Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions

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12 December 2020

The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition

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12 December 2020

NADPH oxidase: an update

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12 December 2020

AKT and oxidative stress team up to kill cancer cells.

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12 December 2020

Manganese superoxide dismutase activity regulates transitions between quiescent and proliferative growth

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12 December 2020

The phosphoinositide 3-kinase pathway

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12 December 2020

Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells

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12 December 2020

Thiol-based mechanisms of the thioredoxin and glutaredoxin systems: implications for diseases in the cardiovascular system

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12 December 2020

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

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12 December 2020

Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B.

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12 December 2020

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

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12 December 2020

Identification of a tumour suppressor network opposing nuclear Akt function

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12 December 2020

The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

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12 December 2020

Mitochondrial DNA mutations in human cancer

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12 December 2020

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

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12 December 2020

Protein kinase B activation by reactive oxygen species is independent of tyrosine kinase receptor phosphorylation and requires SRC activity

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12 December 2020

Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations

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12 December 2020

c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability

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12 December 2020

The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

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12 December 2020

Redox stress regulates cell proliferation and apoptosis of human hepatoma through Akt protein phosphorylation

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12 December 2020

10.1007/S00018-009-0099-Y

Identifiers

DOI

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21 August 2017

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PubMed ID

19629388