Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits (Q28237197)

Transitions between epithelial and mesenchymal states in development and disease

Europe PubMed Central

title

Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits (English)

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2

Robert A Weinberg

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Kornelia Polyak

series ordinal

1

object named as

Kornelia Polyak

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language of work or name

English

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publication date

April 2009

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published in

Nature Reviews Cancer

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volume

9

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page(s)

265-73

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issue

4

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cites work

1 reference

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Complex networks orchestrate epithelial-mesenchymal transitions

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Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis

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The epithelial-mesenchymal transition generates cells with properties of stem cells

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Generation of breast cancer stem cells through epithelial-mesenchymal transition

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Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers

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Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

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Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers

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TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells

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Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

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The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression

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Cancer genes and the pathways they control

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E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines.

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Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways

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Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer

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Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

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The Wnt antagonist sFRP1 in colorectal tumorigenesis

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Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer

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Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins

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Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells

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Hypoxic regulation of metastasis via hypoxia-inducible factors

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Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells

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Notch signaling mediates hypoxia-induced tumor cell migration and invasion

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Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

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Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment

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Expression of Snail protein in tumor-stroma interface

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Signal pathway profiling of epithelial and stromal compartments of colonic carcinoma reveals epithelial-mesenchymal transition

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Co-culturing human prostate carcinoma cells with hepatocytes leads to increased expression of E-cadherin

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The epithelial cell default-phenotype hypothesis and its implications for cancer

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Mesenchymal to epithelial transition in development and disease.

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Transcriptional regulation of cell polarity in EMT and cancer

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SLUG (SNAI2) deletions in patients with Waardenburg disease

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The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

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MicroRNAs as regulators of epithelial-mesenchymal transition.

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Comparison of bone marrow, disseminated tumour cells and blood-circulating tumour cells in breast cancer patients after primary treatment

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Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype

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Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers

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Molecular portraits of human breast tumours

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Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

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The CD44+/CD24- phenotype is enriched in basal-like breast tumors

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let-7 regulates self renewal and tumorigenicity of breast cancer cells

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Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy

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Epithelial-to-mesenchymal transition confers resistance to apoptosis in three murine mammary epithelial cell lines

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MicroRNA expression and function in cancer

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Snail and slug play distinct roles during breast carcinoma progression.

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The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression

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Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition

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Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancer

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Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma.

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Aberrant methylation of the estrogen receptor and E-cadherin 5' CpG islands increases with malignant progression in human breast cancer

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1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19262571

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19262571

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Zinc-finger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19262571

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRC2620

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

132216

1000031106

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132216

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference