Targeting RAS signalling pathways in cancer therapy (Q28201363)

Europe PubMed Central

title

Targeting RAS signalling pathways in cancer therapy (English)

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author

Julian Downward

series ordinal

1

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language of work or name

English

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publication date

January 2003

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published in

Nature Reviews Cancer

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volume

3

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page(s)

11-22

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issue

1

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Understanding Ras: 'it ain't over 'til it's over'.

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Increasing complexity of Ras signaling.

31 March 2020

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Function and regulation of ras.

31 March 2020

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K-ras is an essential gene in the mouse with partial functional overlap with N-ras

31 March 2020

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Membrane association and targeting of prenylated Ras-like GTPases

31 March 2020

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All ras proteins are polyisoprenylated but only some are palmitoylated

31 March 2020

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A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

31 March 2020

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The Ras branch of small GTPases: Ras family members don't fall far from the tree

31 March 2020

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Small GTP-binding proteins

31 March 2020

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Integration of calcium and Ras signalling.

31 March 2020

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Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

31 March 2020

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Ras signalling on the endoplasmic reticulum and the Golgi

31 March 2020

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RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs

31 March 2020

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Stimulation of p21 ras upon T-cell activation

31 March 2020

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Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

31 March 2020

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Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation

31 March 2020

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Signal transduction and the Ets family of transcription factors

31 March 2020

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Ras and Rho regulation of the cell cycle and oncogenesis

31 March 2020

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

31 March 2020

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Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

31 March 2020

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Cellular survival: a play in three Akts

31 March 2020

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Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

31 March 2020

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Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

31 March 2020

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Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.

31 March 2020

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Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451

31 March 2020

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Phospholipase C(epsilon): a novel Ras effector

31 March 2020

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Hyperactive Ras as a therapeutic target in neurofibromatosis type 1.

31 March 2020

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The EGF receptor family as targets for cancer therapy

31 March 2020

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EGF mutant receptor vIII as a molecular target in cancer therapy

31 March 2020

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Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

31 March 2020

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PTEN: life as a tumor suppressor

31 March 2020

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Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies

31 March 2020

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Farnesyltransferase inhibitors: promises and realities

31 March 2020

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Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

31 March 2020

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Actin' up: RhoB in cancer and apoptosis

31 March 2020

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Inhibitors of protein farnesyltransferase as novel anticancer agents

31 March 2020

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Potential roles of antisense technology in cancer chemotherapy

31 March 2020

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Antisense oligonucleotides demonstrate a dominant role of c-Ki-RAS proteins in regulating the proliferation of diploid human fibroblasts

31 March 2020

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Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

31 March 2020

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MEK kinase activity is not necessary for Raf-1 function

31 March 2020

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Phase II trial with ISIS 5132 in patients with small-cell (SCLC) and non-small cell (NSCLC) lung cancer. A European Organization for Research and Treatment of Cancer (EORTC) Early Clinical Studies Group report

31 March 2020

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Rational therapeutic intervention in cancer: kinases as drug targets

31 March 2020

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Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

31 March 2020

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A synthetic inhibitor of the mitogen-activated protein kinase cascade

31 March 2020

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Identification of a novel inhibitor of mitogen-activated protein kinase kinase

31 March 2020

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Development of anticancer drugs targeting the MAP kinase pathway

31 March 2020

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Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

31 March 2020

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Discovery of a novel Raf kinase inhibitor

31 March 2020

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Mutations of the BRAF gene in human cancer

31 March 2020

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The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development

31 March 2020

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Protein tyrosine kinase inhibitors: new treatment modalities?

31 March 2020

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Epidermal growth factor receptor tyrosine kinase inhibitors

31 March 2020

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The ErbB receptor family: a therapeutic target for cancer

31 March 2020

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ZD1839: targeting the epidermal growth factor receptor in cancer therapy

31 March 2020

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Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies

31 March 2020

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Analysis of the transcriptional program induced by Raf in epithelial cells

31 March 2020

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Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: a new paradigm for cancer therapy

31 March 2020

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Phase I study of anti--epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer

31 March 2020

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Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

31 March 2020

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Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-delta

31 March 2020

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Successful induction of immune responses against mutant ras in melanoma patients using intradermal injection of peptides and GM-CSF as adjuvant.

31 March 2020

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Toward a PKB inhibitor: modification of a selective PKA inhibitor by rational design

31 March 2020

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Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation

31 March 2020

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Concepts in Ras-directed therapy

31 March 2020

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RNA aptamers that specifically bind to the Ras-binding domain of Raf-1

31 March 2020

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Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells.

31 March 2020

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Guanosine triphosphatase stimulation of oncogenic Ras mutants

31 March 2020

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The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

31 March 2020

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Hsp90 inhibitors as novel cancer chemotherapeutic agents

31 March 2020

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Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment

31 March 2020

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The emerging fields of suicide gene therapy and virotherapy.

31 March 2020

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Replication-selective viruses for cancer therapy

31 March 2020

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Social controls on cell survival and cell death

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC969

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

988812

1044435378

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988812

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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