New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway (Q29616144)

Europe PubMed Central

title

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway (English)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=10200246

30 April 2017

author name string

Cantley LC

series ordinal

1

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30 April 2017

Neel BG

series ordinal

2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=10200246

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=10200246

30 April 2017

language of work or name

1 reference

30 April 2017

publication date

13 April 1999

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=10200246

Proceedings of the National Academy of Sciences of the United States of America

30 April 2017

published in

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30 April 2017

volume

96

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page(s)

4240-5

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issue

8

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Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

30 April 2017

cites work

1 reference

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The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33561

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33561

Regulation of cell death protease caspase-9 by phosphorylation

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33561

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33561

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33561

30 April 2017

Phosphoinositide kinases

1 reference

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Pten is essential for embryonic development and tumour suppression

30 April 2017

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Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

30 April 2017

1 reference

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

30 April 2017

1 reference

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Roles of the complex formation of SHPS-1 with SHP-2 in insulin-stimulated mitogen-activated protein kinase activation

30 April 2017

1 reference

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A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

30 April 2017

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Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

30 April 2017

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MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines

30 April 2017

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3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

30 April 2017

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A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast

30 April 2017

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

30 April 2017

1 reference

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P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

30 April 2017

1 reference

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Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

30 April 2017

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Signalling through the lipid products of phosphoinositide-3-OH kinase

30 April 2017

1 reference

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TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33561

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33561

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33561

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33561

Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33561

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

30 April 2017

1 reference

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The N-terminal domains of tensin and auxilin are phosphatase homologues

30 April 2017

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

30 April 2017

1 reference

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PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

30 April 2017

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

30 April 2017

1 reference

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The retinoblastoma protein and cell cycle control

30 April 2017

1 reference

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Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

30 April 2017

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Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

30 April 2017

1 reference

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PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

30 April 2017

1 reference

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Purification and characterization of phosphoinositide 3-kinase from rat liver

30 April 2017

1 reference

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Oncogenes and signal transduction

30 April 2017

1 reference

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The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33561

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

3 June 2018

1 reference

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The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33561

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

3 June 2018

1 reference

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In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma

3 June 2018

1 reference

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Mechanisms and consequences of activation of protein kinase B/Akt

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33561

Allelic imbalance, including deletion of PTEN/MMACI, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33561

PTEN: sometimes taking it off can be better than putting it on.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33561

Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

3 June 2018

1 reference

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PTEN/MMAC1 mutations in endometrial cancers.

3 June 2018

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Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors.

3 June 2018

1 reference

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Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma.

3 June 2018

1 reference

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A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains

3 June 2018

1 reference

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Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.

3 June 2018

1 reference

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Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

3 June 2018

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Protein tyrosine phosphatases in signal transduction.

3 June 2018

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PI3K: downstream AKTion blocks apoptosis

3 June 2018

1 reference

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A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

3 June 2018

1 reference

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Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase

3 June 2018

1 reference

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From form to function: signaling by protein tyrosine phosphatases.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33561

Form and function in protein dephosphorylation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33561

Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol

3 June 2018

1 reference

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Production of novel polyphosphoinositides in vivo is linked to cell transformation by polyomavirus middle T antigen

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33561

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33561

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

3 June 2018

1 reference

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PTEN/MMAC1 mutations and EGFR amplification in glioblastomas.

3 June 2018

1 reference

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Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33561

PDZ proteins organize synaptic signaling pathways

26 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33561

Infrequent mutations in the PTEN/MMAC1 gene among primary breast cancers.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33561

Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation

26 November 2018

1 reference

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Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors.

26 November 2018

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Mutation of the PTEN (MMAC1) tumor suppressor gene in a subset of glioblastomas but not in meningiomas with loss of chromosome arm 10q.

26 November 2018

1 reference

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Frequent inactivation of PTEN/MMAC1 in primary prostate cancer

26 November 2018

1 reference

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PTEN gene mutations are seen in high-grade but not in low-grade gliomas.

26 November 2018

1 reference

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Somatic mutations of PTEN in glioblastoma multiforme.

26 November 2018

1 reference

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Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues

26 November 2018

1 reference

12 December 2020

A study of the PTEN/MMAC1 gene in 136 breast cancer families

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12 December 2020

Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies

1 reference

12 December 2020

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1 reference

12 December 2020

Exclusion of PTEN and 10q22-24 as the susceptibility locus for juvenile polyposis syndrome

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12 December 2020

Identifiers

DOI

10.1073/PNAS.96.8.4240

1 reference

1398087

ADS bibcode

1999PNAS...96.4240C

0 references

1398087

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=10200246

2 references

30 April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=10200246

2 references

30 April 2017