High-Intensity Raf Signal Causes Cell Cycle Arrest Mediated by p21Cip1 (Q40023426)

16 September 2017

High-Intensity Raf Signal Causes Cell Cycle Arrest Mediated by p21Cip1 (English)

1 reference

https://api.crossref.org/works/10.1128/MCB.17.9.5588

13 November 2024

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13 November 2024

cell cycle

1 reference

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13 November 2024

author name string

A. Sewing

1

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13 November 2024

B. Wiseman

2

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13 November 2024

A. C. Lloyd

3

1 reference

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13 November 2024

H. Land

4

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13 November 2024

publication date

1 September 1997

1 reference

PMC publication ID

232407

16 September 2017

September 1997

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=9271434

https://mcb.asm.org/content/mcb/17/9/5588.full.pdf

13 November 2024

language of work or name

English

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work available at URL

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http://mcb.asm.org/cgi/content/abstract/17/9/5588

13 November 2024

online access status

open access

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https://europepmc.org/articles/PMC232407

13 November 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9271434

https://europepmc.org/articles/PMC232407?pdf=render

13 November 2024

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9271434

https://journals.asm.org/doi/pdf/10.1128/MCB.17.9.5588

13 November 2024

1 reference

https://api.crossref.org/works/10.1128/MCB.17.9.5588

https://www.tandfonline.com/doi/pdf/10.1128/MCB.17.9.5588

13 November 2024

1 reference

https://api.crossref.org/works/10.1128/MCB.17.9.5588

Molecular and Cellular Biology

13 November 2024

published in

1 reference

16 September 2017

17

1 reference

16 September 2017

9

1 reference

16 September 2017

5588-5597

1 reference

Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein

16 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21Cip1

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Regulation of transcription by MAP kinase cascades

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Interference with p53 protein inhibits hematopoietic and muscle differentiation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Ste12 and Mcm1 regulate cell cycle-dependent transcription of FAR1

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Self-contained, tetracycline-regulated retroviral vector system for gene delivery to mammalian cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Mammalian Ras interacts directly with the serine/threonine kinase Raf

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

WAF1, a potential mediator of p53 tumor suppression

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Alternative splicing of human cyclin E

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Inhibition of platelet-derived growth factor- and epidermal growth factor-mediated mitogenesis and signaling in 3T3 cells expressing delta Raf-1:ER, an estradiol-regulated form of Raf-1.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

MyoD-induced expression of p21 inhibits cyclin-dependent kinase activity upon myocyte terminal differentiation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

The Ras signaling pathway in Drosophila

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Inhibition of cyclin-dependent kinases by p21

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Radiation-induced cell cycle arrest compromised by p21 deficiency

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Nerve growth factor-induced alteration in the response of PC12 pheochromocytoma cells to epidermal growth factor

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

Ras-mediated cell cycle arrest is altered by nuclear oncogenes to induce Schwann cell transformation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

B-raf, a new member of the raf family, is activated by DNA rearrangement

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232407

The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus

22 September 2017

1 reference

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Improved retroviral vectors for gene transfer and expression

22 September 2017

1 reference

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Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

22 September 2017

1 reference

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Induction of transformation and DNA synthesis after microinjection of raf proteins

22 September 2017

1 reference

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Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2.

22 September 2017

1 reference

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Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

22 September 2017

1 reference

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Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src

22 September 2017

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Nuclear localization and regulation of erk- and rsk-encoded protein kinases

22 September 2017

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Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein

22 September 2017

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Activation of the MAP kinase pathway by the protein kinase raf

22 September 2017

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Raf-1 activates MAP kinase-kinase

22 September 2017

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MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase

22 September 2017

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Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

22 September 2017

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Function and regulation of ras.

22 September 2017

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MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

25 September 2017

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Threshold responses to the dorsal regulatory gradient and the subdivision of primary tissue territories in the Drosophila embryo

25 September 2017

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Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism

25 September 2017

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CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein

25 September 2017

1 reference

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Cell determination strategies in the Drosophila eye.

25 September 2017

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Absence of p53 allows direct immortalization of hematopoietic cells by the myc and raf oncogenes

25 September 2017

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The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression

25 September 2017

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Nerve growth factor-induced growth arrest and induction of p21Cip1/WAF1 in NIH-3T3 cells expressing TrkA.

17 June 2018

1 reference

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A dominant-negative mutant of raf blocks mitogen-activated protein kinase activation by growth factors and oncogenic p21ras.

17 June 2018

1 reference

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Human cyclin D1 encodes a labile nuclear protein whose synthesis is directly induced by growth factors and suppressed by cyclic AMP.

17 June 2018

1 reference

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Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblasts

17 June 2018

1 reference

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Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts

17 June 2018

1 reference

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v-raf confers CSF-1 independent growth to a macrophage cell line and leads to immediate early gene expression without MAP-kinase activation

17 June 2018

1 reference

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Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system

17 June 2018

1 reference

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Mice lacking cyclin D1 are small and show defects in eye and mammary gland development

17 June 2018

1 reference

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Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

17 June 2018

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Selective immortalization of murine macrophages from fresh bone marrow by a raf/myc recombinant murine retrovirus

17 June 2018

1 reference

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v-mil induces autocrine growth and enhanced tumorigenicity in v-myc-transformed avian macrophages

17 June 2018

1 reference

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Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ

17 June 2018

1 reference

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Retroviral gene transfer using safe and efficient packaging cell lines

17 June 2018

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Androgen receptor phosphorylation, turnover, nuclear transport, and transcriptional activation. Specificity for steroids and antihormones

17 June 2018

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Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinase

17 June 2018

1 reference

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Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

17 June 2018

1 reference

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Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation

17 June 2018

1 reference

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Cooperating oncogenes converge to regulate cyclin/cdk complexes

17 June 2018

1 reference

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Regulation of the cell cycle machinery by oncogenic ras.

20 August 2018

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FAR1 links the signal transduction pathway to the cell cycle machinery in yeast.

20 August 2018

1 reference

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The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development.

20 August 2018

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A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways

20 August 2018

1 reference

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Cyclin D1 and p21/waf1 are both involved in p53 growth suppression

20 August 2018

1 reference

12 December 2020

Effect of nerve growth factor on the expression of cell cycle regulatory proteins in PC12 cells: dissection of the neurotrophic response from the anti-mitogenic response

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12 December 2020

Raf regulates positive selection

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12 December 2020

Myc activation of cyclin E/Cdk2 kinase involves induction of cyclin E gene transcription and inhibition of p27(Kip1) binding to newly formed complexes

1 reference

12 December 2020

Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line

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12 December 2020

Specific growth response of ras-transformed embryo fibroblasts to tumour promoters

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12 December 2020

Insulin and insulin-like growth factors stimulate deoxyribonucleic acid synthesis in PC12 pheochromocytoma cells

1 reference

12 December 2020

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

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12 December 2020

Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines

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12 December 2020

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis

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12 December 2020

Induction of p21 (WAF-1/CIP1) during differentiation

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12 December 2020

EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor

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12 December 2020

PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation

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12 December 2020

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage

1 reference

12 December 2020

Regulation of p21WAF1/CIP1 expression through mitogen-activated protein kinase signaling pathway

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12 December 2020

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13 November 2024

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13 November 2024

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13 November 2024

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13 November 2024

Identifiers

1 reference

16 September 2017

1 reference

PMC publication ID

232407

16 September 2017

1 reference

PMC publication ID

232407