c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability (Q74243929)

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scientific article published on 01 May 2002

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English	c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability	scientific article published on 01 May 2002

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scholarly article

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9 November 2019

c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability (English)

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9 November 2019

reactive oxygen species

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Omid Vafa

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Mark Wade

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Suzanne Kern

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Michelle Beeche

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Tej K Pandita

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Garret M Hampton

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Geoffrey M Wahl

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9 November 2019

publication date

1 May 2002

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9 November 2019

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9 November 2019

9

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1031-1044

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9 November 2019

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

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Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins.

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Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

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c-Myc target genes involved in cell growth, apoptosis, and metabolism

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The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle

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DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

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Transient excess of MYC activity can elicit genomic instability and tumorigenesis

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Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation.

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Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

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Mediation of c-Myc-induced apoptosis by p53.

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14-3-3sigma is a p53-regulated inhibitor of G2/M progression

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Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair

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Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

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c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release

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p53: puzzle and paradigm

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Myc represses transcription of the growth arrest gene gas1

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1 reference

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Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

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1 reference

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1 reference

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A model for p53-induced apoptosis

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1 reference

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1 reference

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1 reference

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based on heuristic

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1 reference

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7 January 2021

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1 reference

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1 reference

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Identifiers

10.1016/S1097-2765(02)00520-8

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9 November 2019

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9 November 2019

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