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c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability (Q74243929)

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scientific article published on 01 May 2002

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English	c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability	scientific article published on 01 May 2002

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9 November 2019

c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability (English)

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9 November 2019

reactive oxygen species

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Omid Vafa

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9 November 2019

Mark Wade

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9 November 2019

Suzanne Kern

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9 November 2019

Michelle Beeche

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9 November 2019

Tej K Pandita

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9 November 2019

Garret M Hampton

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9 November 2019

Geoffrey M Wahl

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9 November 2019

publication date

1 May 2002

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9 November 2019

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9 November 2019

9

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9 November 2019

5

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9 November 2019

1031-1044

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9 November 2019

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

1 reference

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A p53-dependent S-phase checkpoint helps to protect cells from DNA damage in response to starvation for pyrimidine nucleotides

1 reference

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Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins.

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Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

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p14ARF links the tumour suppressors RB and p53

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Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

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7 January 2021

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c-Myc target genes involved in cell growth, apoptosis, and metabolism

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DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

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7 January 2021

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Primary cells suppress oncogene-dependent apoptosis

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7 January 2021

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Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

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Cluster analysis and display of genome-wide expression patterns

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Definition of a consensus binding site for p53

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Induction of apoptosis in fibroblasts by c-myc protein

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Disruption of Redox Homeostasis in the Transforming Growth Factor-α/c-myc Transgenic Mouse Model of Accelerated Hepatocarcinogenesis

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Transient excess of MYC activity can elicit genomic instability and tumorigenesis

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The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

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Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation.

1 reference

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7 January 2021

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Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

1 reference

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7 January 2021

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Genetic background alters the spectrum of tumors that develop in p53-deficient mice

1 reference

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7 January 2021

based on heuristic

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Mediation of c-Myc-induced apoptosis by p53.

1 reference

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7 January 2021

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14-3-3sigma is a p53-regulated inhibitor of G2/M progression

1 reference

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7 January 2021

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p53 mutations in human cancers

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Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair

1 reference

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7 January 2021

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Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

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A transactivation-deficient mouse model provides insights into Trp53 regulation and function

1 reference

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Mammalian Cell Fusion : Induction of Premature Chromosome Condensation in Interphase Nuclei

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7 January 2021

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c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release

1 reference

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7 January 2021

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

1 reference

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1 reference

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7 January 2021

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Identification of p53 as a sequence-specific DNA-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900520-8

7 January 2021

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p53: puzzle and paradigm

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7 January 2021

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Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1 reference

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Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species

1 reference

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7 January 2021

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Myc represses transcription of the growth arrest gene gas1

1 reference

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7 January 2021

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Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress.

1 reference

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7 January 2021

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Endonuclease G is an apoptotic DNase when released from mitochondria

1 reference

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7 January 2021

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A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

1 reference

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7 January 2021

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Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1 reference

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7 January 2021

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1 reference

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1 reference

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7 January 2021

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1 reference

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1 reference

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1 reference

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A model for p53-induced apoptosis

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7 January 2021

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inferred from DOI database lookup

Inefficient growth arrest in response to dNTP starvation stimulates gene amplification through bridge-breakage-fusion cycles

1 reference

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7 January 2021

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inferred from DOI database lookup

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1 reference

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7 January 2021

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inferred from DOI database lookup

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1 reference

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inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

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inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

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7 January 2021

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1 reference

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inferred from DOI database lookup

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1 reference

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1 reference

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inferred from DOI database lookup

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1 reference

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7 January 2021

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inferred from DOI database lookup

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1 reference

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7 January 2021

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inferred from DOI database lookup

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1 reference

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7 January 2021

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Identifiers

10.1016/S1097-2765(02)00520-8

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PubMed publication ID

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9 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12049739%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

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