Activation of AKT kinases in cancer: implications for therapeutic targeting (Q36226730)

12 August 2017

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title

Activation of AKT kinases in cancer: implications for therapeutic targeting (English)

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12 August 2017

Alfonso Bellacosa

1

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12 August 2017

C Chandra Kumar

series ordinal

2

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12 August 2017

Antonio Di Cristofano

series ordinal

3

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12 August 2017

Joseph Robert Testa

series ordinal

4

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12 August 2017

1 January 2005

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Advances in Cancer Research

12 August 2017

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12 August 2017

94

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12 August 2017

29-86

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Delayed mammary gland involution in MMTV-AKT1 transgenic mice

12 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Mechanism of activation and function of protein kinase B.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Immunohistochemical localization of phosphorylated AKT in multiple myeloma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Frequent activation of AKT2 kinase in human pancreatic carcinomas.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Incidence of homogeneously staining regions in non-Hodgkin lymphomas

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Genetic hits and mutation rate in colorectal tumorigenesis: Versatility of Knudson's theory and implications for cancer prevention

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Akt activation by growth factors is a multiple-step process: the role of the PH domain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

A portrait of AKT kinases: human cancer and animal models depict a family with strong individualities

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Lost in translation: dysregulation of cap-dependent translation and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

LKB1, a protein kinase regulating cell proliferation and polarity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Advances in protein kinase B signalling: AKTion on multiple fronts

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Frequent monoallelic deletion of PTEN and its reciprocal associatioin with PIK3CA amplification in gastric carcinoma.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

The phosphoinositide 3-kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

The AMP-activated protein kinase cascade--a unifying system for energy control

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Inhibition of cell survival signal protein kinase B/Akt by curcumin in human prostate cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Transforming activity and mitosis-related expression of the AKT2 oncogene: evidence suggesting a link between cell cycle regulation and oncogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Phosphatase and tensin homologue phosphorylation in the C-terminal regulatory domain is frequently observed in acute myeloid leukaemia and associated with poor clinical outcome

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Clinical development of mammalian target of rapamycin inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Cellular survival: a play in three Akts

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

The multiple roles of PTEN in tumor suppression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Pten is essential for embryonic development and tumour suppression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Impaired Fas response and autoimmunity in Pten+/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Structural insight into substrate specificity and regulatory mechanisms of phosphoinositide 3-kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

New antitumor substances of natural origin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Mechanisms and consequences of activation of protein kinase B/Akt

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Regulation of neuronal survival by the serine-threonine protein kinase Akt

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Akt stimulates aerobic glycolysis in cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

PTEN: one gene, many syndromes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Inhibition of PDK-1 activity causes a reduction in cell proliferation and survival

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

PI3K: downstream AKTion blocks apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

PI3K/Akt and apoptosis: size matters

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

A family with severe insulin resistance and diabetes due to a mutation in AKT2.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Adenovirus infection inactivates the translational inhibitors 4E-BP1 and 4E-BP2

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Structure, regulation and function of PKB/AKT--a major therapeutic target

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Analysis of DNA copy number aberrations in hepatitis C virus-associated hepatocellular carcinomas by conventional CGH and array CGH.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Akt signaling: linking membrane events to life and death decisions

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

New target, new drug, old paradigm

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https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Crystal structure of an inactive Akt2 kinase domain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

TSC2 mediates cellular energy response to control cell growth and survival

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Expression of a mutated form of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3'-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Expression, purification, characterization and homology modeling of active Akt/PKB, a key enzyme involved in cell survival signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Tuberous sclerosis: from tubers to mTOR.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Essential role of PDK1 in regulating cell size and development in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Non-small cell lung cancers frequently express phosphorylated Akt; an immunohistochemical study.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

TSC2: filling the GAP in the mTOR signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Targeting the PI3K-Akt pathway in human cancer: rationale and promise

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

eIF4E--from translation to transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Rheb fills a GAP between TSC and TOR.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Germline mutations in PTEN are present in Bannayan-Zonana syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Coordinate regulation of translation by the PI 3-kinase and mTOR pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

TORward AKTually useful mouse models

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Oncogenic transformation induced by membrane-targeted Akt2 and Akt3.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

The Akt pathway: molecular targets for anti-cancer drug development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Isolation of DNA sequences amplified at chromosome 19q13.1-q13.2 including the AKT2 locus in human pancreatic cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Increased expression of phosphorylated p70S6 kinase and Akt in papillary thyroid cancer tissues.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Akt/PKB activation in gastric carcinomas correlates with clinicopathologic variables and prognosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Induction of ovarian cancer by defined multiple genetic changes in a mouse model system

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Regulation of protein kinases in insulin, growth factor and Wnt signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Cell metabolism in the regulation of programmed cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Akt regulates growth by directly phosphorylating Tsc2

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Does the ribosome translate cancer?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Adenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

High frequency of mutations of the PIK3CA gene in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

The biology and clinical relevance of the PTEN tumor suppressor pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Will mTOR inhibitors make it as cancer drugs?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Unravelling the activation mechanisms of protein kinase B/Akt

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Incidence, mechanism and prognostic value of activated AKT in pancreas cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Phosphorylated Akt/PKB controls cell growth and apoptosis in intraductal papillary-mucinous tumor and invasive ductal adenocarcinoma of the pancreas

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

The LKB1 tumor suppressor negatively regulates mTOR signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

PIK3CA is implicated as an oncogene in ovarian cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Dysregulated PTEN-PKB and negative receptor status in human breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

PTEN: life as a tumor suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Thymic lymphoma induction by the AKT8 murine retrovirus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

The AKT1 proto-oncogene maps to human chromosome 14, band q32.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Akt kinases in breast cancer and the results of adjuvant therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Genetic analysis of protein kinase B (AKT) in Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Serine/threonine kinase AKT is frequently activated in human bile duct cancer and is associated with increased radioresistance.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Loss of PTEN expression followed by Akt phosphorylation is a poor prognostic factor for patients with endometrial cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

AKT plays a central role in tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Fibronectin activates matrix metalloproteinase-9 secretion via the MEK1-MAPK and the PI3K-Akt pathways in ovarian cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Amplification of 19q13.1–q13.2 sequences in ovarian cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Pten dose dictates cancer progression in the prostate

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

The PI3K-PDK1 connection: more than just a road to PKB

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Akt activation and localisation correlate with tumour invasion and oncogene expression in thyroid cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Mutations of the PH domain of protein kinase B (PKB/AKT) are absent in human epidermal skin tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Mutations of the activation-associated phosphorylation sites at codons 308 and 473 of protein kinase B are absent in human melanoma.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Absence of mutations in the pleckstrin homology (PH) domain of protein kinase B (PKB/Akt) in malignant melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Expression of the eukaryotic translation initiation factors 4E and 2alpha in non-Hodgkin's lymphomas

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

On the Origin of Cancer Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Regulation of sensitivity to TRAIL by the PTEN tumor suppressor.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Role of Akt/protein kinase B in metabolism.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

PTEN signaling pathways in melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Three-dimensional structure of the tyrosine kinase c-Src

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Dysregulation of cellular signaling by HER2 in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2805%2994002-5

7 January 2021

10.1016/S0065-230X(05)94002-5

Identifiers

DOI

1 reference

12 August 2017

1 reference