The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells (Q42481082)

1 November 2017

The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells (English)

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1 November 2017

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15

G B Mills

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1 November 2017

Y Lu

1

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Y Z Lin

2

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R LaPushin

3

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B Cuevas

4

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X Fang

5

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S X Yu

6

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M A Davies

7

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1 November 2017

H Khan

8

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T Furui

9

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M Mao

10

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R Zinner

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M C Hung

12

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P Steck

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K Siminovitch

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1 November 2017

language of work or name

English

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publication date

1 November 1999

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1 November 2017

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18

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7034-7045

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50

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1203183

1 November 2017

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cites work

Expression of the transforming growth factor-alpha/epidermal growth factor receptor pathway in normal human breast epithelial cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

Mutational analysis of the PTEN/MMAC1 gene in non-Hodgkin's lymphoma.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

Ras signalling and apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

Mechanism of action of the immunosuppressant rapamycin

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

21 January 2018

Integrins and anoikis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

Integrin signaling and cell growth control

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

Flow cytometric assessment of three different methods for the measurement of in vitro apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

The modular phosphorylation and activation of p70s6k.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

PIK3CA is implicated as an oncogene in ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

Restoration of wild-type PTEN expression leads to apoptosis, induces differentiation, and reduces telomerase activity in human glioma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

The insulin-like growth factor-I receptor signaling pathways are important for tumorigenesis and inhibition of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

Apoptosis induction by E2F-1 via adenoviral-mediated gene transfer results in growth suppression of head and neck squamous cell carcinoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203183

inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1038/SJ.ONC.1203183

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Dimensions Publication ID

1 November 2017

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