Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine). (Q43919081)

28 November 2017

Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine). (English)

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28 November 2017

Saori Sato

1

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28 November 2017

Naoya Fujita

series ordinal

2

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28 November 2017

Takashi Tsuruo

series ordinal

3

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28 November 2017

language of work or name

English

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publication date

1 March 2002

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28 November 2017

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28 November 2017

21

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28 November 2017

1727-1738

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28 November 2017

11

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205225

28 November 2017

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UCN-01 (7-hydoxystaurosporine) inhibits in vivo growth of human cancer cells through selective perturbation of G1 phase checkpoint machinery

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3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

21 January 2018

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

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Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

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PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

21 January 2018

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Disruption of 3-phosphoinositide-dependent kinase 1 (PDK1) signaling by the anti-tumorigenic and anti-proliferative agent n-alpha-tosyl-l-phenylalanyl chloromethyl ketone

21 January 2018

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Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

21 January 2018

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Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

21 January 2018

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Constitutive activation of protein kinase B and phosphorylation of p47phox by a membrane-targeted phosphoinositide 3-kinase

21 January 2018

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A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

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The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

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Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase

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The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2

21 January 2018

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Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

21 January 2018

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Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons

21 January 2018

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D4-GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis

21 January 2018

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Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

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Cleavage and inactivation of antiapoptotic Akt/PKB by caspases during apoptosis

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Modulation of Akt kinase activity by binding to Hsp90

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Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte-macrophage colony stimulating

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Apoptosis and cancer drug targeting

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The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2

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Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

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Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

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Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

21 January 2018

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Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

21 January 2018

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An information-intensive approach to the molecular pharmacology of cancer.

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Mechanism of activation of protein kinase B by insulin and IGF-1

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7 January 2021

Acceleration of apoptotic cell death after the cleavage of Bcl-XL protein by caspase-3-like proteases

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7 January 2021

Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C

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7 January 2021

Pharmacokinetics and pharmacodynamics of a novel protein kinase inhibitor, UCN-01

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7 January 2021

7-Hydroxystaurosporine (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53

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7 January 2021

UCN-01, a selective inhibitor of protein kinase C from Streptomyces.

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7 January 2021

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities

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7 January 2021

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

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7 January 2021

The correction for bias in prevalence estimation with screening tests.

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205225

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Dimensions Publication ID

28 November 2017

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