Incidence, mechanism and prognostic value of activated AKT in pancreas cancer (Q36648105)

15 August 2017

Incidence, mechanism and prognostic value of activated AKT in pancreas cancer (English)

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15 August 2017

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M G Schlieman

1

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15 August 2017

B N Fahy

2

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15 August 2017

R Ramsamooj

3

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15 August 2017

L Beckett

4

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15 August 2017

R J Bold

5

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15 August 2017

language of work or name

English

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publication date

1 December 2003

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British Journal of Cancer

15 August 2017

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15 August 2017

89

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15 August 2017

11

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15 August 2017

2110-2115

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https://scigraph.springernature.com/pub.10.1038/sj.bjc.6601396

15 August 2017

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cites work

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Activation of the PI3K/Akt pathway and chemotherapeutic resistance

30 September 2017

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Pancreatic cancer biology and genetics

30 September 2017

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Present and future treatment of pancreatic cancer

30 September 2017

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

30 September 2017

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Transforming growth factor-beta 2 is a transcriptional target for Akt/protein kinase B via forkhead transcription factor

30 September 2017

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Immunohistochemical demonstration of phospho-Akt in high Gleason grade prostate cancer

30 September 2017

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Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction.

30 September 2017

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Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients

30 September 2017

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HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

30 September 2017

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Therapy for pancreatic cancer with a recombinant humanized anti-HER2 antibody (herceptin).

30 September 2017

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Prognosis of human pancreatic adenocarcinoma: review of clinical and histopathological variables and possible uses of new molecular methods

30 September 2017

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Akt is activated in response to an apoptotic signal.

30 September 2017

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Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation

28 June 2018

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K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression.

28 June 2018

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The grade of pancreatic ductal carcinoma is an independent prognostic factor and is superior to the immunohistochemical assessment of proliferation.

28 June 2018

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HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway

28 June 2018

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Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

28 June 2018

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Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression.

28 June 2018

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Differential mechanisms of constitutive Akt/PKB activation and its influence on gene expression in pancreatic cancer cells

20 September 2018

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Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376856

Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma

20 September 2018

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Adenoviral-mediated expression of MMAC/PTEN inhibits proliferation and metastasis of human prostate cancer cells.

20 September 2018

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Role of Akt in growth and survival of PANC-1 pancreatic cancer cells

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376856

Wortmannin inhibits pkb/akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376856

PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376856

Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376856

The Ras/phosphatidylinositol 3-kinase and Ras/ERK pathways function as independent survival modules each of which inhibits a distinct apoptotic signaling pathway in sympathetic neurons.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376856

Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376856

Overexpression of HER2/neu oncogene in human pancreatic carcinoma

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376856

Overexpression of HER2/neu in solid tumours: an immunohistochemical survey

20 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.BJC.6601396

Predictive factors for long-term survival in patients with pancreatic carcinoma

21 January 2018

1 reference

12 December 2020

Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas

1 reference

12 December 2020

Pathology and biology of pancreatic ductal adenocarcinoma

1 reference

12 December 2020

The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells

1 reference

12 December 2020

Pancreatic cancer cell proliferation is phosphatidylinositol 3-kinase dependent

1 reference

12 December 2020

Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer

1 reference

12 December 2020

Prognostic factors of long-term survival after resective procedures for pancreatic cancer

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.BJC.6601396

1 reference

15 August 2017

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15 August 2017

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