The enzymes of β-lactam biosynthesis (Q34310470)

1 August 2017

The enzymes of β-lactam biosynthesis (English)

1 reference

1 August 2017

Christopher J. Schofield

6

1 reference

1 August 2017

Luc Henry

3

0 references

Refaat B. Hamed

object named as

Refaat B Hamed

1

0 references

Christian Ducho

object named as

Christian Ducho

4

0 references

Michael A McDonough

object named as

Michael A McDonough

5

0 references

author name string

J Ruben Gomez-Castellanos

2

1 reference

1 August 2017

1 January 2013

1 reference

1 August 2017

Natural Product Reports

1 reference

1 August 2017

30

1 reference

1 August 2017

21-107

1 reference

1 August 2017

1

1 reference

Discovery research: the scientific challenge of finding new antibiotics

1 August 2017

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Introduction: antibiotic resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Critical shortage of new antibiotics in development against multidrug-resistant bacteria-Time to react is now.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Novel approaches to developing new antibiotics for bacterial infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Penicillin-binding proteins and the mechanism of action of beta-lactam antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Peptidoglycan structure and architecture

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The architecture of the murein (peptidoglycan) in gram-negative bacteria: vertical scaffold or horizontal layer(s)?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

beta-lactams: variations on a chemical theme, with some surprising biological results

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Beta-lactam compounds as apparently uncompetitive inhibitors of HIV-1 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Potent beta-lactam inhibitors of human cytomegalovirus protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Monocyclic β-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Fresh from the pipeline. Ezetimibe.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Synthesis of anticancer beta-lactams: mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Asymmetric synthesis of anticancer beta-lactams via Staudinger reaction: utilization of chiral ketene from carbohydrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Optically active 1,3,4,4-tetrasubstituted β-lactams: synthesis and evaluation as tumor cell growth inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structural studies on human 2-oxoglutarate dependent oxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The human oxygen sensing machinery and its manipulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The enzymology of clavam and carbapenem biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Proteins of the penicillin biosynthesis pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Chemistry and biosynthesis of clavulanic acid and other clavams

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

New reactions in clavulanic acid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structural studies of natural product biosynthetic proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-D-alanyl-D-alanine

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Inhibition of elastase by N-sulfonylaryl beta-lactams: anatomy of a stable acyl-enzyme complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structural basis for the interaction of lactivicins with serine beta-lactamases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Resistance to beta-lactam antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Resistance to antibiotics mediated by target alterations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Efflux pumps as antimicrobial resistance mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Outer membrane permeability and antibiotic resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The beta-lactamase cycle: a tale of selective pressure and bacterial ingenuity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Detection and spread of Escherichia coli possessing the plasmid-borne carbapenemase KPC-2 in Brooklyn, New York

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structural aspects for evolution of beta-lactamases from penicillin-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Metallo-beta-lactamases: the quiet before the storm?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Extended-spectrum beta-lactamases: a clinical update

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Inhibition of the class C beta-lactamase from Acinetobacter spp.: insights into effective inhibitor design

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

21 January 2018

b-Lactamase inhibitors

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Three decades of beta-lactamase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

In vitro and in vivo activities of AM-112, a novel oxapenem.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

In vitro activity of the {beta}-lactamase inhibitor NXL104 against KPC-2 carbapenemase and Enterobacteriaceae expressing KPC carbapenemases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Synthesis of penicillin: 6-aminopenicillanic acid in penicillin fermentations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Cephalosporin C, a New Antibiotic containing Sulphur and D-α-Aminoadipic Acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Enzymatic modifications of cephalosporins by cephalosporin acylase and other enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Unconventional serine proteases: variations on the catalytic Ser/His/Asp triad configuration

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structural comparison of Ntn-hydrolases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Aztreonam: the first monobactam

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The beta-lactam antibiotics: past, present, and future

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structure-activity relationships amongst beta-lactamase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Three-dimensional structures of enzymes useful for beta-lactam antibiotic production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Evolution of beta-lactam biosynthesis genes and recruitment of trans-acting factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Biosynthetic concepts for the production of β-lactam antibiotics in Penicillium chrysogenum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The enzymes involved in biosynthesis of penicillin and cephalosporin; their structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

delta-(L-alpha-Aminoadipyl)-L-cysteinyl-D-valine synthetase, that mediates the first committed step in penicillin biosynthesis, is a cytosolic enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The Mechanism of ACV Synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Biosynthesis and molecular genetics of cephamycins. Cephamycins produced by actinomycetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Characterization of the cmcH genes of Nocardia lactamdurans and Streptomyces clavuligerus encoding a functional 3'-hydroxymethylcephem O-carbamoyltransferase for cephamycin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Insights into cephamycin biosynthesis: the crystal structure of CmcI from Streptomyces clavuligerus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Substrate specificity of nonribosomal peptide synthetase modules responsible for the biosynthesis of the oligopeptide moiety of cephabacin in Lysobacter lactamgenus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Biosynthetic pathway of cephabacins in Lysobacter lactamgenus: molecular and biochemical characterization of the upstream region of the gene clusters for engineering of novel antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Lysine control of α-aminoadipate and penicillin synthesis in Penicillium chrysogenum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Lysine biosynthesis and metabolism in fungi

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The α-Aminoadipate Pathway for Lysine Biosynthesis in Fungi

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Lysine is catabolized to 2-aminoadipic acid in Penicillium chrysogenum by an omega-aminotransferase and to saccharopine by a lysine 2-ketoglutarate reductase. Characterization of the omega-aminotransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

A gene encoding lysine 6-aminotransferase, which forms the beta-lactam precursor alpha-aminoadipic acid, is located in the cluster of cephamycin biosynthetic genes in Nocardia lactamdurans

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Cloning and location of a gene governing lysine epsilon-aminotransferase, an enzyme initiating beta-lactam biosynthesis in Streptomyces spp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

L-lysine epsilon-aminotransferase involved in cephamycin C synthesis in Streptomyces lactamdurans

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Effect of exogenous lysine on the expression of early cephamycin C biosynthetic genes and antibiotic production in Nocardia lactamdurans MA4213.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Possible involvement of the lysine epsilon-aminotransferase gene (lat) in the expression of the genes encoding ACV synthetase (pcbAB) and isopenicillin N synthase (pcbC) in Streptomyces clavuligerus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

pcd mutants of Streptomyces clavuligerus still produce cephamycin C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Early cephamycin biosynthetic genes are expressed from a polycistronic transcript in Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Purification and characterization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Penicillium chrysogenum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase, the multienzyme integrating the four primary reactions in beta-lactam biosynthesis, as a model peptide synthetase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Reactions catalyzed by mature and recombinant nonribosomal peptide synthetases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Chapter 13. Nonribosomal peptide synthetases mechanistic and structural aspects of essential domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Molecular mechanisms underlying nonribosomal peptide synthesis: approaches to new antibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Penicillin and cephalosporin biosynthetic genes: structure, organization, regulation, and evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Modular Peptide Synthetases Involved in Nonribosomal Peptide Synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

A nonribosomal system of peptide biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Biochemical studies on the activity of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Substrate specificity of L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase from Cephalosporium acremonium: demonstration of the structure of several unnatural tripeptide products

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Kinetic analysis of three activated phenylalanyl intermediates generated by the initiation module PheATE of gramicidin S synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Epimerization of the D-valine portion in the biosynthesis of actinomycin D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Crystal structure of the termination module of a nonribosomal peptide synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Nonribosomal peptide synthetases: structures and dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structural insights into nonribosomal peptide enzymatic assembly lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Dynamic thiolation–thioesterase structure of a non-ribosomal peptide synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Purification of isopenicillin N synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The thioredoxin system of Penicillium chrysogenum and its possible role in penicillin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Cloning and nucleotide sequence determination of the isopenicillin N synthetase gene from Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The cephamycin biosynthetic genes pcbAB, encoding a large multidomain peptide synthetase, and pcbC of Nocardia lactamdurans are clustered together in an organization different from the same genes in Acremonium chrysogenum and Penicillium chrysogenum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Cloning and characterization of the isopenicillin N synthase gene of Streptomyces griseus NRRL 3851 and studies of expression and complementation of the cephamycin pathway in Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Ferrous active site of isopenicillin N synthase: genetic and sequence analysis of the endogenous ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Molecular studies on isopenicillin N synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

X-ray absorption spectroscopic studies of the high-spin iron(II) active site of isopenicillin N synthase: evidence for Fe-S interaction in the enzyme-substrate complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The mechanism for isopenicillin N synthase from density-functional modeling highlights the similarities with other enzymes in the 2-His-1-carboxylate family

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The reaction cycle of isopenicillin N synthase observed by X-ray diffraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Crystallographic studies on the reaction of isopenicillin N synthase with an unsaturated substrate analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structural studies on the reaction of isopenicillin N synthase with the truncated substrate analogues delta-(L-alpha-aminoadipoyl)-L-cysteinyl-glycine and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alanine

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Unexpected oxidation of a depsipeptide substrate analogue in crystalline isopenicillin N synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Geometric and electronic structure/function correlations in non-heme iron enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

VTVH-MCD and DFT studies of thiolate bonding to [FeNO]7/[FeO2]8 complexes of isopenicillin N synthase: substrate determination of oxidase versus oxygenase activity in nonheme Fe enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Dioxygen activation at mononuclear nonheme iron active sites: enzymes, models, and intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Dioxygen Activation by Enzymes with Mononuclear Non-Heme Iron Active Sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The biosynthesis of penicillins and cephalosporins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Interactions of isopenicillin N synthase with cyclopropyl-containing substrate analogues reveal new mechanistic insight

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Alternative oxidation by isopenicillin N synthase observed by X-ray diffraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Purification to homogeneity and characterization of acyl coenzyme A:6-aminopenicillanic acid acyltransferase of Penicillium chrysogenum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Cloning and characterization of the acyl-coenzyme A: 6-aminopenicillanic-acid-acyltransferase gene of Penicillium chrysogenum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Molecular characterization of the acyl-coenzyme A:isopenicillin N acyltransferase gene (penDE) from Penicillium chrysogenum and Aspergillus nidulans and activity of recombinant enzyme in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Molecular cloning and functional identification of a novel phenylacetyl-CoA ligase gene from Penicillium chrysogenum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Cloning and characterization of a novel CoA-ligase gene from Penicillium chrysogenum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Amplification and disruption of the phenylacetyl-CoA ligase gene of Penicillium chrysogenum encoding an aryl-capping enzyme that supplies phenylacetic acid to the isopenicillin N-acyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

ORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

On the production of alpha, beta-heterodimeric acyl-coenzyme A: isopenicillin N-acyltransferase of Penicillium chrysogenum. Studies using a recombinant source.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structures of an isopenicillin N converting Ntn-hydrolase reveal different catalytic roles for the active site residues of precursor and mature enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

In vivo post-translational processing and subunit reconstitution of cephalosporin acylase from Pseudomonas sp. 130.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The 2.0 A crystal structure of cephalosporin acylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Biosynthetic alanine racemase of Salmonella typhimurium: purification and characterization of the enzyme encoded by the alr gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Characterization and expression in Streptomyces lividans of cefD and cefE genes from Nocardia lactamdurans: the organization of the cephamycin gene cluster differs from that in Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The beta-lactam biosynthesis genes for isopenicillin N epimerase and deacetoxycephalosporin C synthetase are expressed from a single transcript in Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

A novel epimerization system in fungal secondary metabolism involved in the conversion of isopenicillin N into penicillin N in Acremonium chrysogenum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Purification and initial characterization of an enzyme with deacetoxycephalosporin C synthetase and hydroxylase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Copurification and characterization of deacetoxycephalosporin C synthetase/hydroxylase from Cephalosporium acremonium

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Analysis of penicillin N ring expansion activity from Streptomyces clavuligerus by ion-pair high-pressure liquid chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Cloning and sequencing of the beta-lactam hydroxylase gene (cefF) from Streptomyces clavuligerus: gene duplication may have led to separate hydroxylase and expandase activities in the actinomycetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structure of a cephalosporin synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Conformational flexibility of the C terminus with implications for substrate binding and catalysis revealed in a new crystal form of deacetoxycephalosporin C synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS)

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Alteration of the co-substrate selectivity of deacetoxycephalosporin C synthase. The role of arginine 258

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The structural basis of cephalosporin formation in a mononuclear ferrous enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Directed evolution and rational approaches to improving Streptomyces clavuligerus deacetoxycephalosporin C synthase for cephalosporin production

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Relevant double mutations in bioengineered Streptomyces clavuligerus deacetoxycephalosporin C synthase result in higher binding specificities which improve penicillin bioconversion

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Controlling the substrate selectivity of deacetoxycephalosporin/deacetylcephalosporin C synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

A complete library of amino acid alterations at N304 in Streptomyces clavuligerus deacetoxycephalosporin C synthase elucidates the basis for enhanced penicillin analogue conversion

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The kinetic properties of various R258 mutants of deacetoxycephalosporin C synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Active site mutations of recombinant deacetoxycephalosporin C synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

C-terminus modification of Streptomyces clavuligerus deacetoxycephalosporin C synthase improves catalysis with an expanded substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Mutation of N304 to leucine in Streptomyces clavuligerus deacetoxycephalosporin C synthase creates an enzyme with increased penicillin analogue conversion

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Probing the penicillin sidechain selectivity of recombinant deacetoxycephalosporin C synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Stereochemistry of the incorporation of valine methyl groups into methylene groups in cephalosporin C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Characterization of the iron- and 2-oxoglutarate-binding sites of human prolyl 4-hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Occurrence of a new cephalosporoate in a culture broth of a Cephalosporium acremonium mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Contrasting fates for 6-alpha-methylpenicillin N upon oxidation by deacetoxycephalosporin C synthase (DAOCS) and deacetoxy/deacetylcephalosporin C synthase (DAOC/DACS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Cephamycins, a New Family of β-Lactam Antibiotics I. Production by Actinomycetes, Including Streptomyces lactamdurans sp. n

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Biosynthesis of a 7-α-methoxycephalosporin. Incorporation of molecular oxygen

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The conversion of cephalosporins to 7 alpha-methoxycephalosporins by cell-free extracts of Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

An adenosine triphosphate-dependent carbamoylphosphate-3-hydroxymethylcephem O-carbamoyltransferase from Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Origin and evolution of peptide-modifying dioxygenases and identification of the wybutosine hydroxylase/hydroperoxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

A two-protein component 7 alpha-cephem-methoxylase encoded by two genes of the cephamycin C cluster converts cephalosporin C to 7-methoxycephalosporin C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Interaction of the two proteins of the methoxylation system involved in cephamycin C biosynthesis. Immunoaffinity, protein cross-linking, and fluorescence spectroscopy studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Cloning of a Streptomyces clavuligerus DNA fragment encoding the cephalosporin 7 alpha-hydroxylase and its expression in Streptomyces lividans

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The cefG gene of Cephalosporium acremonium is linked to the cefEF gene and encodes a deacetylcephalosporin C acetyltransferase closely related to homoserine O-acetyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Synthesis of deactoxycephalosporin C by a mutant of Cephalosporium acremonium

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Purification of acetyl coenzyme A: deacetylacephalosporin C O-acetyltransferase from Acremonium chrysogenum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Cloning and disruption of the cefG gene encoding acetyl coenzyme A: deacetylcephalosporin C o-acetyltransferase from Acremonium chrysogenum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Molecular cloning of acetyl coenzyme A: deacetylcephalosporin C o-acetyltransferase cDNA from Acremonium chrysogenum: sequence and expression of catalytic activity in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The last step in cephalosporin C formation revealed: crystal structures of deacetylcephalosporin C acetyltransferase from Acremonium chrysogenum in complexes with reaction intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Improved beta-lactam acylases and their use as industrial biocatalysts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Draft genome sequence of Streptomyces clavuligerus NRRL 3585, a producer of diverse secondary metabolites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Complete genome sequence of Streptomyces cattleya NRRL 8057, a producer of antibiotics and fluorometabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Complete genome sequence of Actinosynnema mirum type strain (101).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Directed evolution of enzymes and biosynthetic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Semi-rational approaches to engineering enzyme activity: combining the benefits of directed evolution and rational design

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Directed evolution of enzymes for biocatalysis and the life sciences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Improved biocatalysts by directed evolution and rational protein design

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Metabolic engineering of beta-lactam production

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Transcriptional and bioinformatic analysis of the 56.8 kb DNA region amplified in tandem repeats containing the penicillin gene cluster in Penicillium chrysogenum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The penicillin gene cluster is amplified in tandem repeats linked by conserved hexanucleotide sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Cloning, characterization, and use in strain improvement of the Cephalosporium acremonium gene cefG encoding acetyl transferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Expression of the cefG gene is limiting for cephalosporin biosynthesis in Acremonium chrysogenum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Environmentally safe production of 7-aminodeacetoxycephalosporanic acid (7-ADCA) using recombinant strains of Acremonium chrysogenum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Cloning and expression of a hybrid Streptomyces clavuligerus cefE gene in Penicillium chrysogenum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Production of cephalosporin intermediates by feeding adipic acid to recombinant Penicillium chrysogenum strains expressing ring expansion activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Engineering of Penicillium chrysogenum for fermentative production of a novel carbamoylated cephem antibiotic precursor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The Penicillium chrysogenum aclA gene encodes a broad-substrate-specificity acyl-coenzyme A ligase involved in activation of adipic acid, a side-chain precursor for cephem antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Clavulanic acid biosynthesis and genetic manipulation for its overproduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Origin of the β-Lactam Carbons in Clavulanic Acid from an Unusual Thiamine Pyrophosphate-Mediated Reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Observation of an acryloyl-thiamin diphosphate adduct in the first step of clavulanic acid biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structural and mechanistic studies on N(2)-(2-carboxyethyl)arginine synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzyme in the clavulanic acid biosynthesis pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

beta-Lactam synthetase: a new biosynthetic enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Crystal structure of carbapenam synthetase (CarA)

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Inhibition and alternate substrate studies on the mechanism of carbapenam synthetase from Erwinia carotovora

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Definition of the common and divergent steps in carbapenem β-lactam antibiotic biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Three-dimensional structure of Escherichia coli asparagine synthetase B: a short journey from substrate to product

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structure of beta-lactam synthetase reveals how to synthesize antibiotics instead of asparagine

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Kinetic mechanism of Escherichia coli asparagine synthetase B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Crotonase Catalysis Enables Flexible Production of Functionalized Prolines and Carbapenams

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Stereoselective C-C bond formation catalysed by engineered carboxymethylproline synthases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Enzymatic synthesis of monocyclic beta-lactams

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Engineering the synthetic potential of β-lactam synthetase and the importance of catalytic loop dynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Biosynthesis of carbapenem antibiotics: new carbapenam substrates for carbapenem synthase (CarC).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: an unusual oxidative enzyme in natural product biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Elucidation of the order of oxidations and identification of an intermediate in the multistep clavaminate synthase reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Crystal structure of a clavaminate synthase-Fe(II)-2-oxoglutarate-substrate-NO complex: evidence for metal centered rearrangements

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Mechanism of dioxygen activation in 2-oxoglutarate-dependent enzymes: a hybrid DFT study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Incorporation of oxygen into the succinate co-product of iron(II) and 2-oxoglutarate dependent oxygenases from bacteria, plants and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structural basis for the erythro-stereospecificity of the l-arginine oxygenase VioC in viomycin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Studies on the formation and incorporation of streptolidine in the biosynthesis of the peptidyl nucleoside antibiotic streptothricin F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Cloning, sequencing and disruption of a gene from Streptomyces clavuligerus involved in clavulanic acid biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Crystal structures of Bacillus caldovelox arginase in complex with substrate and inhibitors reveal new insights into activation, inhibition and catalysis in the arginase superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Purification and characterization of clavaminate synthase from Streptomyces antibioticus. A multifunctional enzyme of clavam biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Five additional genes are involved in clavulanic acid biosynthesis in Streptomyces clavuligerus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Expansion of the clavulanic acid gene cluster: identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The clavulanic acid biosynthetic cluster of Streptomyces clavuligerus: genetic organization of the region upstream of the car gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

A pathway-specific transcriptional activator regulates late steps of clavulanic acid biosynthesis in Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The claR gene of Streptomyces clavuligerus, encoding a LysR-type regulatory protein controlling clavulanic acid biosynthesis, is linked to the clavulanate-9-aldehyde reductase (car) gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Regulatory mechanisms controlling antibiotic production in Streptomyces clavuligerus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

21 January 2018

The ATP-grasp enzymes

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

A diverse superfamily of enzymes with ATP-dependent carboxylate-amine/thiol ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Enzymatic synthesis of D-alanyl-D-alanine. Control of D-alanine:D-alanine ligase (ADP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Short-chain dehydrogenases/reductases (SDRs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Short-chain dehydrogenases/reductases (SDR)

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Short-chain dehydrogenases/reductases (SDR): the 2002 update

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Chemical and biological evolution of nucleotide-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Critical residues for structure and catalysis in short-chain dehydrogenases/reductases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Clavulanic acid dehydrogenase: structural and biochemical analysis of the final step in the biosynthesis of the beta-lactamase inhibitor clavulanic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Prediction of the occurrence of the ADP-binding beta alpha beta-fold in proteins, using an amino acid sequence fingerprint

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Site-specific mutagenesis of Drosophila alcohol dehydrogenase: evidence for involvement of tyrosine-152 and lysine-156 in catalysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Two oligopeptide-permease-encoding genes in the clavulanic acid cluster of Streptomyces clavuligerus are essential for production of the beta-lactamase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Crystal structures of an oligopeptide-binding protein from the biosynthetic pathway of the beta-lactamase inhibitor clavulanic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The structural basis of sequence-independent peptide binding by OppA protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Atomic structure and specificity of bacterial periplasmic receptors for active transport and chemotaxis: variation of common themes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structure and functions of the GNAT superfamily of acetyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Crystal structure of tabtoxin resistance protein complexed with acetyl coenzyme A reveals the mechanism for beta-lactam acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Improvement of L-arginine production by overexpression of a bifunctional ornithine acetyltransferase in Corynebacterium crenatum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Arginine boxes and the argR gene in Streptomyces clavuligerus: evidence for a clear regulation of the arginine pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Clavulanic acid biosynthesis in Streptomyces clavuligerus: gene cloning and characterization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Two proteins with ornithine acetyltransferase activity show different functions in Streptomyces clavuligerus: Oat2 modulates clavulanic acid biosynthesis in response to arginine

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Two sets of paralogous genes encode the enzymes involved in the early stages of clavulanic acid and clavam metabolite biosynthesis in Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Anatomy of a simple acyl intermediate in enzyme catalysis: combined biophysical and modeling studies on ornithine acetyl transferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The molecular structure of ornithine acetyltransferase from Mycobacterium tuberculosis bound to ornithine, a competitive inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

X-ray structure of a serine protease acyl-enzyme complex at 0.95-A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Clavulanic acid, a beta-lactamase inhibitor: biosynthesis and molecular genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Biosynthesis and molecular genetics of clavulanic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Alanylclavam biosynthetic genes are clustered together with one group of clavulanic acid biosynthetic genes in Streptomyces clavuligerus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Enzymes catalyzing the early steps of clavulanic acid biosynthesis are encoded by two sets of paralogous genes in Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

A two-component regulatory system involved in clavulanic acid production

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

A gene located downstream of the clavulanic acid gene cluster in Streptomyces clavuligerus ATCC 27064 encodes a putative response regulator that affects clavulanic acid production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Role of σ-factor (orf21) in clavulanic acid production in Streptomyces clavuligerus NRRL3585.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Genome-wide gene expression changes in an industrial clavulanic acid overproduction strain of Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Rational strain improvement for enhanced clavulanic acid production by genetic engineering of the glycolytic pathway in Streptomyces clavuligerus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The paralogous pairs of genes involved in clavulanic acid and clavam metabolite biosynthesis are differently regulated in Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Streptomyces clavuligerus has a second copy of the proclavaminate amidinohydrolase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

5S clavam biosynthetic genes are located in both the clavam and paralog gene clusters in Streptomyces clavuligerus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

A comparison of the clavam biosynthetic gene clusters in Streptomyces antibioticus Tü1718 and Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Recent Developments in the Field of β-Lactam Antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Thienamycin: development of imipenem-cilastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

N-Acetimidoyl- and N-formimidoylthienamycin derivatives: antipseudomonal .beta.-lactam antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Regulation and biosynthesis of carbapenem antibiotics in bacteria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Identification, characterization, and regulation of a cluster of genes involved in carbapenem biosynthesis in Photorhabdus luminescens

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Analysis of the carbapenem gene cluster of Erwinia carotovora: definition of the antibiotic biosynthetic genes and evidence for a novel beta-lactam resistance mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Analysis of bacterial carbapenem antibiotic production genes reveals a novel β-lactam biosynthesis pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Carbapenem biosynthesis: confirmation of stereochemical assignments and the role of CarC in the ring stereoinversion process from L-proline

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Carbapenem antibiotic production in Erwinia carotovora is regulated by CarR, a homologue of the LuxR transcriptional activator.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Molecular genetics of carbapenem antibiotic biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Carboxymethylproline synthase (CarB), an unusual carbon-carbon bond-forming enzyme of the crotonase superfamily involved in carbapenem biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Carboxymethylproline synthase from Pectobacterium carotorova: a multifaceted member of the crotonase superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Evidence that thienamycin biosynthesis proceeds via C-5 epimerization: ThnE catalyzes the formation of (2S,5S)-trans-carboxymethylproline.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Synthesis of deuterium labelled L- and D-glutamate semialdehydes and their evaluation as substrates for carboxymethylproline synthase (CarB)--implications for carbapenem biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Crystal structure of carbapenem synthase (CarC)

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Mechanisms and structures of crotonase superfamily enzymes--how nature controls enolate and oxyanion reactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The crotonase superfamily: divergently related enzymes that catalyze different reactions involving acyl coenzyme a thioesters

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Mutational analysis of the thienamycin biosynthetic gene cluster from Streptomyces cattleya

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Thioester Hydrolysis and CC Bond Formation by Carboxymethylproline Synthase from the Crotonase Superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Synthesis of regio- and stereoselectively deuterium-labelled derivatives of L-glutamate semialdehyde for studies on carbapenem biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Divergent Function in the Crotonase Superfamily: An Anhydride Intermediate in the Reaction Catalyzed by 3-Hydroxyisobutyryl-CoA Hydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Biotechnological potential of the ethylmalonyl-CoA pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Characterization of 2-octenoyl-CoA carboxylase/reductase utilizing pteB from Streptomyce avermitilis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Unusual carbon fixation gives rise to diverse polyketide extender units

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Mechanistic studies on three 2-oxoglutarate-dependent oxygenases of flavonoid biosynthesis: anthocyanidin synthase, flavonol synthase, and flavanone 3beta-hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

On the Evolution of Biochemical Syntheses

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Synthesis of (3S,5R)-carbapenam-3-carboxylic acid and its role in carbapenem biosynthesis and the stereoinversion problem

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structural and mechanistic studies on γ-butyrobetaine hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Epimerization and desaturation by carbapenem synthase (CarC). A hybrid DFT study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Stereochemistry of methylation in thienamycin biosynthesis: example of a methyl transfer from methionine with retention of configuration

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The Biosynthetic Gene Cluster for the β-Lactam Carbapenem Thienamycin in Streptomyces cattleya

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Non-heme iron oxygenases generate natural structural diversity in carbapenem antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Identification of transcriptional activators for thienamycin and cephamycin C biosynthetic genes within the thienamycin gene cluster from Streptomyces cattleya

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

GriC and GriD constitute a carboxylic acid reductase involved in grixazone biosynthesis in Streptomyces griseus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Enzymes that catalyse SN2 reaction mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Stereochemical analysis of the methyl transfer catalyzed by cobalamin-dependent methionine synthase from Escherichia coli B

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Co-C bond activation in methylmalonyl-CoA mutase by stabilization of the post-homolysis product Co2+ cobalamin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Spectroscopic and computational studies on the adenosylcobalamin-dependent methylmalonyl-CoA mutase: evaluation of enzymatic contributions to Co-C bond activation in the Co3+ ground state

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Studies on methylmalonyl-CoA mutase from Propionibacterium shermanii.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Adenosyl radical: reagent and catalyst in enzyme reactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Radical S-adenosylmethionine enzymes: mechanism, control and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structure of a Coenzyme A Pyrophosphatase from Deinococcus radiodurans: a Member of the Nudix Family

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Insights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangement

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Geometrical reaction coordinates. II. Nucleophilic addition to a carbonyl group

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Terpenoid alkaloids of the Buxaceae family with potential biological importance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Gastric and duodenal antiulcer activity of alkaloids: a review.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Activity-guided isolation of steroidal alkaloid antiestrogen-binding site inhibitors from Pachysandra procumbens

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Monamphilectine A, a potent antimalarial β-lactam from marine sponge Hymeniacidon sp: isolation, structure, semisynthesis, and bioactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Distinctive attributes of β-lactam target proteins in Acinetobacter baumannii relevant to development of new antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Biosynthesis of monobactam compounds: origin of the carbon atoms in the beta-lactam ring

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Sulfur metabolism in the biosynthesis of monobactams

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

In vitro antibacterial properties of BRL 36650, a novel 6 alpha-substituted penicillin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Nocardicin A: stereochemical and biomimetic studies of monocyclic β-lactam formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The biosynthetic gene cluster for a monocyclic beta-lactam antibiotic, nocardicin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Purification, characterization, and cloning of an S-adenosylmethionine-dependent 3-amino-3-carboxypropyltransferase in nocardicin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Mutational analysis and characterization of nocardicin C-9' epimerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Mutational analysis of nocK and nocL in the nocardicin a producer Nocardia uniformis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Identification and characterization of NocR as a positive transcriptional regulator of the beta-lactam nocardicin A in Nocardia uniformis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Physical identification of a chromosomal locus encoding biosynthetic genes for the lipopeptide calcium-dependent antibiotic (CDA) of Streptomyces coelicolor A3(2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Formation of novel secondary metabolites by bacterial multimodular assembly lines: deviations from textbook biosynthetic logic.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Coelichelin, a new peptide siderophore encoded by the Streptomyces coelicolor genome: structure prediction from the sequence of its non-ribosomal peptide synthetase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Discovery of a new peptide natural product by Streptomyces coelicolor genome mining.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Isolation and characterization of a peptide isomerase from funnel web spider venom

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Role of the cytochrome P450 NocL in nocardicin A biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

High-resolution crystal structure of cytochrome P450cam

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Isolation and proof of structure of wildfire toxin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Synthesis of tabtoxinine-.delta.-lactam

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Inhibition of Glutamine Synthetase from Pea by Tabtoxinine-beta-lactam

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Role of glutamine synthetase adenylylation in the self-protection of Pseudomonas syringae subsp. "tabaci" from its toxin, tabtoxinine-beta-lactam

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Self-protection of Pseudomonas syringae pv. "tabaci" from its toxin, tabtoxinine-beta-lactam

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Tabtoxin-resistant protein: overexpression, purification, and characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The biosynthetic gene cluster for the beta-lactam antibiotic tabtoxin in Pseudomonas syringae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Characterization of dapB, a gene required by Pseudomonas syringae pv. tabaci BR2.024 for lysine and tabtoxinine-beta-lactam biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

A possible role for acetylated intermediates in diaminopimelate and tabtoxinine-beta-lactam biosynthesis in Pseudomonas syringae pv. tabaci BR2.024.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The lemA gene required for pathogenicity of Pseudomonas syringae pv. syringae on bean is a member of a family of two-component regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Regulation of tabtoxin production by the lemA gene in Pseudomonas syringae

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Metagenomics, biotechnology with non-culturable microbes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Epigenome manipulation as a pathway to new natural product scaffolds and their congeners

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Fungal secondary metabolites - strategies to activate silent gene clusters

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

High resolution crystal structures of the trans-enamine intermediates formed by sulbactam and clavulanic acid and E166A SHV-1 {beta}-lactamase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Sulbactam forms only minimal amounts of irreversible acrylate-enzyme with SHV-1 beta-lactamase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structure of the covalent adduct formed between Mycobacterium tuberculosis beta-lactamase and clavulanate

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Inhibition of TEM-2 beta-lactamase from Escherichia coli by clavulanic acid: observation of intermediates by electrospray ionization mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Crystal structure of the wide-spectrum binuclear zinc beta-lactamase from Bacteroides fragilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

beta-Lactamase inhibition and in vitro activity of sulbactam and sulbactam/cefoperazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Piperacillin/tazobactam: an updated review of its use in the treatment of bacterial infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Natural beta-lactam antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Regulation of Penicillin Biosynthesis in Filamentous Fungi

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

The cefT gene of Acremonium chrysogenum C10 encodes a putative multidrug efflux pump protein that significantly increases cephalosporin C production

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Molecular analysis of a beta-lactam resistance gene encoded within the cephamycin gene cluster of Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Localization of the lysine epsilon-aminotransferase (lat) and delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase (pcbAB) genes from Streptomyces clavuligerus and production of lysine epsilon-aminotransferase activity in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Secretion systems for secondary metabolites: how producer cells send out messages of intercellular communication

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

On the Mössbauer spectra of isopenicillin N synthase and a model (FeNO)7 (S = 3/2) system

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Structural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide substrate analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Isopenicillin N synthase mediates thiolate oxidation to sulfenate in a depsipeptide substrate analogue: implications for oxygen binding and a link to nitrile hydratase?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Four homologous domains in the primary structure of GrsB are related to domains in a superfamily of adenylate-forming enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Purification and properties of an alpha-methylacyl-CoA racemase from rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Purification and characterization of an alpha-methylacyl-CoA racemase from human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Chiral inversion of 2-arylpropionic acid non-steroidal anti-inflammatory drugs—II Racemization and hydrolysis of (R)- and (S)-ibuprofen-CoA thioesters

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Alpha-methylacyl-CoA racemase--an 'obscure' metabolic enzyme takes centre stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Biochemical characterization of a prokaryotic phenylalanine ammonia lyase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix espanaensis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Characterization of pbpA and pbp2 encoding penicillin-binding proteins located on the downstream of clavulanic acid gene cluster in Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

A conserved lysine in beta-lactam synthetase assists ring cyclization: Implications for clavam and carbapenem biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

A conserved tyrosyl-glutamyl catalytic dyad in evolutionarily linked enzymes: carbapenam synthetase and beta-lactam synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Mechanism for cyclization reaction by clavaminic acid synthase. Insights from modeling studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Characterization and kinetic mechanism of mono- and bifunctional ornithine acetyltransferases from thermophilic microorganisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Comparative analysis of a cryptic thienamycin-like gene cluster identified in Streptomyces flavogriseus by genome mining

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Sulfazecin, a novel beta-lactam antibiotic of bacterial origin. Isolation and chemical characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Sulfazecin and isosulfazecin, novel beta-lactam antibiotics of bacterial origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

Monocyclic beta-lactam antibiotics produced by bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP20065A

In vivo characterization of nonribosomal peptide synthetases NocA and NocB in the biosynthesis of nocardicin A.

21 January 2018

1 reference

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Isolation and partial characterisation of ACV synthetase from Cephalosporium acremonium and Streptomyces clavuligerus. Evidence for the presence of phosphopantothenate in ACV synthetase

21 January 2018

1 reference

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Isolation and partial characterisation of ACV synthetase from Cephalosporium acremonium and Streptomyces clavuligerus

21 January 2018

1 reference

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δ-L -(α-Aminoadipoyl)-L -cysteinyl-D -valine synthetase: the order of peptide bond formation and timing of the epimerisation reaction

21 January 2018

1 reference

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l-δ-(α-Aminoadipoyl)-l-cysteinyl-d-valine Synthetase: Thioesterification of Valine Is Not Obligatory for Peptide Bond Formation†

21 January 2018

1 reference

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Anaerobic Crystallisation of an Isopenicillin N Synthase . Fe(II) . Substrate Complex Demonstrated by X-Ray Studies

21 January 2018

1 reference

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Glutamine-330 is not essential for activity in isopenicillin N synthase from Aspergillus nidulans

21 January 2018

1 reference

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X-ray absorption studies of the ferrous active site of isopenicillin N synthase and related model complexes

21 January 2018

1 reference

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Acyl coenzyme A: 6-aminopenicillanic acid acyltransferase from Penicillium chrysogenum and Aspergillus nidulans

21 January 2018

1 reference

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Studies on the active site of deacetoxycephalosporin C synthase

21 January 2018

1 reference

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The Effect of Cysteine Mutations on Recombinant Deacetoxycephalosporin C Synthase from S. clavuligerus

21 January 2018

1 reference

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The Unusual Bifunctional Catalysis of Epimerization and Desaturation by Carbapenem Synthase

21 January 2018

1 reference

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Two genes involved in penicillin biosynthesis are linked in a 5.1 kb SalI fragment in the genome of Penicillium chrysogenum

21 January 2018

1 reference

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Further evidence for the involvement of a monocyclic β-lactam in the enzymatic conversion of δ-L-α-aminoadipoyl-L-cysteinyl-D-valine into isopenicillin N

21 January 2018

1 reference

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A device for the high-pressure oxygenation of protein crystals

21 January 2018

1 reference

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Penicillin biosynthesis: multiple pathways from a modified substrate

21 January 2018

1 reference

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Cephalosporin C biosynthesis; stereochemistry of the incorporation ofD,L,D-α-aminodipoyl-cysteinyl-(3S)-[2-2H,4-13C]valine into β-lactam compounds

21 January 2018

1 reference

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Cephalosporin biosynthesis: A branched pathway sensitive to an isotope effect

21 January 2018

1 reference

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Competing pathways in the oxidation of -3-ethylidine cephalosporin C by the enzyme deacetoxycephalosporin C synthase (DAOCS)

21 January 2018

1 reference

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Cephalosporin antibiotics can be modified to inhibit human leukocyte elastase

21 January 2018

1 reference

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Binding of a non- β -lactam antibiotic to penicillin-binding proteins

21 January 2018

1 reference

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Further Studies on the Biosynthesis of Tabtoxin (Wildfire Toxin): Incorporation of [2,3-13C2]Pyruvate into the β-Lactam Moiety

21 January 2018

1 reference

9 March 2024

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12 April 2024

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PS-8, a minor carbapenem antibiotic

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Cytotoxic alkaloids of Pachysandra terminalis

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Identifiers

DOI

10.1039/C2NP20065A

1 reference

release_3thqc7khobafxkmt7szkn2oqlu

1 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/3thqc7khobafxkmt7szkn2oqlu

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

23135477

1 reference

PubMed ID

23135477