Structural studies of natural product biosynthetic proteins (Q41647221)

6 October 2017

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title

Structural studies of natural product biosynthetic proteins (English)

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6 October 2017

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Townsend CA

1

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6 October 2017

1 October 1997

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6 October 2017

Chemistry and Biology

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6 October 2017

4

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6 October 2017

10

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6 October 2017

721-730

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Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation

6 October 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Stepwise ring closure in penicillin biosynthesis. Intitial β-lactam formation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Stoichiometry of oxygen consumption in the biosynthesis of isopenicillin from a tripeptide

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

A nonribosomal system of peptide biosynthesis

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Thiolate ligation of the active site Fe2+ of isopenicillin N synthase derives from substrate rather than endogenous cysteine: spectroscopic studies of site-specific Cys----Ser mutated enzymes

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Dioxygen Activation by Enzymes with Mononuclear Non-Heme Iron Active Sites

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

The biosynthesis of penicillins and cephalosporins

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Elucidation of the order of oxidations and identification of an intermediate in the multistep clavaminate synthase reaction

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Oxidative amino aid processing in beta-lactam antibiotic biosynthesis

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

The enzymes involved in biosynthesis of penicillin and cephalosporin; their structure and function

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Protein templates for the biosynthesis of peptide antibiotics

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Rational design of peptide antibiotics by targeted replacement of bacterial and fungal domains

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Structural basis for the activation of phenylalanine in the non-ribosomal biosynthesis of gramicidin S

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Modular organization of genes required for complex polyketide biosynthesis

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme.

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Fatty acid synthase, a proficient multifunctional enzyme

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

The animal fatty acid synthase: one gene, one polypeptide, seven enzymes

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Fatty acid synthase: in vitro complementation of inactive mutants

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Mapping of functional interactions between domains of the animal fatty acid synthase by mutant complementation in vitro

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Structure of fatty acid synthetase from the Harderian gland of guinea pig. Proteolytic dissection and electron microscopic studies

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Stereospecific acyl transfers on the erythromycin-producing polyketide synthase

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Molecular genetics of polyketides and its comparison to fatty acid biosynthesis

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Polyketide synthesis: prospects for hybrid antibiotics

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Polyketide synthase gene manipulation: a structure-function approach in engineering novel antibiotics

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Biosynthesis of Erythromycin and Rapamycin.

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Evidence for a double-helical structure for modular polyketide synthases.

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

On the structure of fatty acid synthetase of yeast

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

A dynamic model for the structure of acyl carrier protein in solution

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Refinement of the NMR structures for acyl carrier protein with scalar coupling data

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2)

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

The Escherichia coli malonyl-CoA:acyl carrier protein transacylase at 1.5-A resolution. Crystal structure of a fatty acid synthase component

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

A mechanism of drug action revealed by structural studies of enoyl reductase

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Structure and function of a squalene cyclase

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

Tinkering with enzymes: what are we learning?

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https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

A single monomeric iron center in clavaminate synthase catalyzes three nonsuccessive oxidative transformations

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2897%2990310-0

7 January 2021

10.1016/S1074-5521(97)90310-0

Identifiers

DOI

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6 October 2017

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PubMed ID

9375250