The enzymes involved in biosynthesis of penicillin and cephalosporin; their structure and function (Q40700468)

22 September 2017

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title

The enzymes involved in biosynthesis of penicillin and cephalosporin; their structure and function (English)

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22 September 2017

Cooper RD

1

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PubMed ID

8081833

22 September 2017

language of work or name

English

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publication date

1 July 1993

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Bioorganic & Medicinal Chemistry

22 September 2017

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22 September 2017

1

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22 September 2017

1-17

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22 September 2017

1

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Partial purification and characterization of isopenicillin N epimerase activity from Streptomyces clavuligerus

22 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Conversion of penicillin N to cephalosporin(s) by cell-free extracts of Cephalosporium acremonium

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Isolation, sequence determination and expression in Escherichia coli of the isopenicillin N synthetase gene from Cephalosporium acremonium

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

The relationship between base composition and codon usage in bacterial genes and its use for the simple and reliable identification of protein-coding sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Cloning and expression of the isopenicillin N synthetase gene from Penicillium chrysogenum

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Cloning, sequence analysis and transcriptional study of the isopenicillin N synthase of Penicillium chrysogenum AS-P-78.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Cloning and expression in Escherichia coli of isopenicillin N synthetase genes from Streptomyces lipmanii and Aspergillus nidulans

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Cloning and characterization of the isopenicillin N synthetase gene mediating the formation of the beta-lactam ring in Aspergillus nidulans.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Cloning and nucleotide sequence determination of the isopenicillin N synthetase gene from Streptomyces clavuligerus

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Cloning and characterization of the isopenicillin N synthase gene of Streptomyces griseus NRRL 3851 and studies of expression and complementation of the cephamycin pathway in Streptomyces clavuligerus

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Cloning and comparative sequence analysis of the gene coding for isopenicillin N synthase in Streptomyces

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Nucleotide sequence of the isopenicillin N synthase gene (pcbC) of the gram negative Flavobacterium sp. SC 12,154.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Analysis of the role of cysteine residues in isopenicillin N synthetase activity by site-directed mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Substrate specificity of isopenicillin N synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

1 reference

7 January 2021

A stereochemical concept for the catalytic mechanism of prolylhydroxylase: applicability to classification and design of inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

NMR studies of the active site of isopenicillin N synthase, a non-heme iron(II) enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Electron spin echo envelope modulation studies of the copper(II)-substituted derivative of isopenicillin N synthase: a structural and spectroscopic model

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Partial purification and catalytic properties of a bifunctional enzyme in the biosynthetic pathway of beta-lactams in Cephalosporium acremonium

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Deacetoxycephalosporin C synthetase and deacetoxycephalosporin C hydroxylase are two separate enzymes in Streptomyces clavuligerus

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Copurification and characterization of deacetoxycephalosporin C synthetase/hydroxylase from Cephalosporium acremonium

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Cloning, characterization, and expression in Escherichia coli of the Streptomyces clavuligerus gene encoding deacetoxycephalosporin C synthetase.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Cloning and sequencing of the beta-lactam hydroxylase gene (cefF) from Streptomyces clavuligerus: gene duplication may have led to separate hydroxylase and expandase activities in the actinomycetes

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

The role of sulphur in cephalosporin biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Enzymic conversion of deuterated analogues of δ--α-aminoadipoyl--cysteinyl--allylglycine, an unnatural substrate for isopenicilin n synthase: A unified theory of second ring closure

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Structural patterns in globular proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

An optimization approach to predicting protein structural class from amino acid composition

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Prediction of protein antigenic determinants from amino acid sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Secondary structure prediction: combination of three different methods.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Cloning and characterization of beta-lactam biosynthetic genes

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Regulation of isopenicillin N synthetase (IPNS) gene expression in Acremonium chrysogenum

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Molecular characterization of the acyl-coenzyme A:isopenicillin N acyltransferase gene (penDE) from Penicillium chrysogenum and Aspergillus nidulans and activity of recombinant enzyme in Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

An electrophoretic molecular karyotype for an industrial strain of Cephalosporium acremonium

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

The beta-lactam biosynthesis genes for isopenicillin N epimerase and deacetoxycephalosporin C synthetase are expressed from a single transcript in Streptomyces clavuligerus

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Isolation of deacetoxycephalosporin C from fermentation broths of Penicillium chrysogenum transformants: construction of a new fungal biosynthetic pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

Characterization and expression in Streptomyces lividans of cefD and cefE genes from Nocardia lactamdurans: the organization of the cephamycin gene cluster differs from that in Streptomyces clavuligerus

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2800%2982098-2

7 January 2021

10.1016/S0968-0896(00)82098-2

Identifiers

DOI

1 reference

22 September 2017

1 reference

PubMed ID

8081833