Directed evolution and rational approaches to improving Streptomyces clavuligerus deacetoxycephalosporin C synthase for cephalosporin production (Q37412448)

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scientific article published on 07 March 2009

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English	Directed evolution and rational approaches to improving Streptomyces clavuligerus deacetoxycephalosporin C synthase for cephalosporin production	scientific article published on 07 March 2009

Statements

scholarly article

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

Directed evolution and rational approaches to improving Streptomyces clavuligerus deacetoxycephalosporin C synthase for cephalosporin production (English)

1 reference

Europe PubMed Central

20 August 2017

directed evolution

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Streptomyces clavuligerus

object named as

Streptomyces clavuligerus

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based on heuristic

inferred from title

author name string

Kian-Sim Goo

1

1 reference

Europe PubMed Central

20 August 2017

Chun-Song Chua

2

1 reference

Europe PubMed Central

20 August 2017

Tiow-Suan Sim

3

1 reference

Europe PubMed Central

20 August 2017

publication date

7 March 2009

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Europe PubMed Central

20 August 2017

Journal of Industrial Microbiology & Biotechnology

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Europe PubMed Central

20 August 2017

36

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Europe PubMed Central

20 August 2017

619-633

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Europe PubMed Central

20 August 2017

5

1 reference

Europe PubMed Central

20 August 2017

The structure of cephalesporin C

1 reference

https://api.crossref.org/works/10.1007%2FS10295-009-0549-4

21 January 2018

Copurification and characterization of deacetoxycephalosporin C synthetase/hydroxylase from Cephalosporium acremonium

1 reference

https://api.crossref.org/works/10.1007%2FS10295-009-0549-4

21 January 2018

Industrial production of beta-lactam antibiotics

1 reference

https://api.crossref.org/works/10.1007%2FS10295-009-0549-4

21 January 2018

Performance of a recombinant strain of Streptomyces lividans for bioconversion of penicillin G to deacetoxycephalosporin G

1 reference

https://api.crossref.org/works/10.1007%2FS10295-009-0549-4

21 January 2018

Analysis of penicillin N ring expansion activity from Streptomyces clavuligerus by ion-pair high-pressure liquid chromatography

1 reference

https://api.crossref.org/works/10.1007%2FS10295-009-0549-4

21 January 2018

Improved expression of a hybrid Streptomyces clavuligerus cefE gene in Penicillium chrysogenum

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MUTAGENIC EFFECTS OF HYDROXYLAMINE IN VIVO.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Industrial enzymatic production of cephalosporin-based beta-lactams.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the ring-cyclization and ring-expansion enzymes of beta-lactam biosynthesis in Cephalosporium acremonium

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Active site mutations of recombinant deacetoxycephalosporin C synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A twisted base? The role of arginine in enzyme-catalyzed proton abstractions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genes for beta-lactam antibiotic biosynthesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of penicillin N to cephalosporin(s) by cell-free extracts of Cephalosporium acremonium

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulatory effect of growth in the presence of alcohols on biotransformation of penicillin G into cephalosporin-type antibiotics by resting cells of Streptomyces clavuligerus NP1

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cephalosporins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological characterisation of Penicillium chrysogenum strains expressing the expandase gene from Streptomyces clavuligerus during batch cultivations. Growth and adipoyl-7-aminodeacetoxycephalosporanic acid production

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altering protein specificity: techniques and applications.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biosynthetic genes for clavulanic acid and cephamycin production occur as a 'super-cluster' in three Streptomyces

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cephabacins, new cephem antibiotics of bacterial origin. I. Discovery and taxonomy of the producing organisms and fermentation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular analysis of the gene cluster involved in cephalosporin biosynthesis from Lysobacter lactamgenus YK90.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular production of biologically active deacetoxycephalosporin C synthase from Streptomyces clavuligerus in Pichia pastoris

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and initial characterization of deacetoxycephalosporin C synthase from Streptomyces clavuligerus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Family shuffling of expandase genes to enhance substrate specificity for penicillin G.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional alpha-KG-dependent non-heme iron enzyme: correlation with mechanisms and reactivities

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A ‘Fine’ Chemical Industry for Life Science Products: Green Solutions to Chemical Challenges

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alteration of the co-substrate selectivity of deacetoxycephalosporin C synthase. The role of arginine 258

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A complete library of amino acid alterations at R306 in Streptomyces clavuligerus deacetoxycephalosporin C synthase demonstrates its structural role in the ring-expansion activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Organization and expression in Pseudomonas putida of the gene cluster involved in cephalosporin biosynthesis from Lysobacter lactamgenus YK90.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relevant double mutations in bioengineered Streptomyces clavuligerus deacetoxycephalosporin C synthase result in higher binding specificities which improve penicillin bioconversion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MatGAT: an application that generates similarity/identity matrices using protein or DNA sequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deacetoxycephalosporin C synthetase and deacetoxycephalosporin C hydroxylase are two separate enzymes in Streptomyces clavuligerus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A spectrophotometric assay for deacetoxycephalosporin C synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The beta-lactam antibiotics: past, present, and future

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Probing the penicillin sidechain selectivity of recombinant deacetoxycephalosporin C synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Engineering Streptomyces clavuligerus deacetoxycephalosporin C synthase for optimal ring expansion activity toward penicillin G

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The development of beta-lactam antibiotics in response to the evolution of beta-lactamases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Refolding and purification of Cephalosporium acremonium deacetoxycephalosporin C synthetase/hydroxylase from granules of recombinant Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutational evidence supporting the involvement of tripartite residues His183, Asp185, and His243 in Streptomyces clavuligerus deacetoxycephalosporin C synthase for catalysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Production of cephalosporin intermediates by feeding adipic acid to recombinant Penicillium chrysogenum strains expressing ring expansion activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serine beta-lactamases and penicillin-binding proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization and expression in Streptomyces lividans of cefD and cefE genes from Nocardia lactamdurans: the organization of the cephamycin gene cluster differs from that in Streptomyces clavuligerus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of the semi-synthetic penicillins and cephalosporins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and characterization of a 2-oxoglutarate-linked ATP-independent deacetoxycephalosporin C synthase of Streptomyces lactamdurans

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and expression of a hybrid Streptomyces clavuligerus cefE gene in Penicillium chrysogenum.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structure of carbapenem synthase (CarC)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of the adipate and dissolved oxygen concentrations on the beta-lactam production during continuous cultivations of a Penicillium chrysogenum strain expressing the expandase gene from Streptomyces clavuligerus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Continuous cultivations of a Penicillium chrysogenum strain expressing the expandase gene from Streptomyces clavuligerus: Kinetics of adipoyl-7-aminodeacetoxycephalosporanic acid and byproduct formations

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deacetoxycephalosporin C synthase isozymes exhibit diverse catalytic activity and substrate specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generating mutant libraries using error-prone PCR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene clusters for beta-lactam antibiotics and control of their expression: why have clusters evolved, and from where did they originate?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of Streptomyces sp. strain DRS-1 and its ampicillin transformation product

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular regulation of beta-lactam biosynthesis in filamentous fungi

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Additivity of mutational effects in proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of the beta-lactam antibiotic, thienamycin, by Streptomyces cattleya

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elucidation of conditions allowing conversion of penicillin G and other penicillins to deacetoxycephalosporins by resting cells and extracts of Streptomyces clavuligerus NP1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and properties of deacetoxycephalosporin C synthase from recombinant Escherichia coli and its comparison with the native enzyme purified from Streptomyces clavuligerus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of a cephalosporin synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Continuous cultivations of a Penicillium chrysogenum strain expressing the expandase gene from Streptomyces clavuligerus: Growth yields and morphological characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New aspects of genes and enzymes for beta-lactam antibiotic biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Controlling the substrate selectivity of deacetoxycephalosporin/deacetylcephalosporin C synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Environmentally safe production of 7-aminodeacetoxycephalosporanic acid (7-ADCA) using recombinant strains of Acremonium chrysogenum.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformational flexibility of the C terminus with implications for substrate binding and catalysis revealed in a new crystal form of deacetoxycephalosporin C synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the active site of deacetoxycephalosporin C synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of N304 to leucine in Streptomyces clavuligerus deacetoxycephalosporin C synthase creates an enzyme with increased penicillin analogue conversion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Penicillin-binding proteins and beta-lactam resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Partial purification and catalytic properties of a bifunctional enzyme in the biosynthetic pathway of beta-lactams in Cephalosporium acremonium

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structural basis of cephalosporin formation in a mononuclear ferrous enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Directed evolution of Streptomyces clavuligerus deacetoxycephalosporin C synthase for enhancement of penicillin G expansion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning, characterization, and expression in Escherichia coli of the Streptomyces clavuligerus gene encoding deacetoxycephalosporin C synthetase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deacetoxycephalosporin C hydroxylase of Streptomyces clavuligerus. Purification, characterization, bifunctionality, and evolutionary implication

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A complete library of amino acid alterations at N304 in Streptomyces clavuligerus deacetoxycephalosporin C synthase elucidates the basis for enhanced penicillin analogue conversion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The kinetic properties of various R258 mutants of deacetoxycephalosporin C synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biosynthesis of penicillins and cephalosporins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sir Edward Abraham's contribution to the development of the cephalosporins: a reassessment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-terminus modification of Streptomyces clavuligerus deacetoxycephalosporin C synthase improves catalysis with an expanded substrate specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and characterization of beta-lactam biosynthetic genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cephamycin C biosynthesis in Streptomyces cattleya: nitrogen source regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative interpretations of double mutations of enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19277744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning, characterization, and expression in Escherichia coli of the Streptomyces clavuligerus gene encoding deacetoxycephalosporin C synthetase.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1128/JB.171.2.754-760.1989

Identifiers

10.1007/S10295-009-0549-4

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

20 August 2017

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