The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1) (Q28573173)

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12 January 2020

title

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1) (English)

2 references

31 January 2017

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D Euan Macintyre

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author name string

Margarita Garcia-Calvo

1

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JeanMarie Lisnock

2

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Meredith Hughes

12

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Anthony Ogawa

14

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Feroze Ujjainwalla

21

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Herbert G Bull

3

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Brian E Hawes

4

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Matthew P Braun

6

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James H Crona

7

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Harry R Davis

8

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Dennis C Dean

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Patricia A Detmers

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Michael P Graziano

11

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Kim A O'neill

15

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Sai Prasad N Iyer

16

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Diane E Shevell

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Marsha M Smith

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Yui S Tang

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Amanda M Makarewicz

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Scott W Altmann

22

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Kevin T Chapman

23

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Nancy A Thornberry

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language of work or name

English

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publication date

31 May 2005

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

12 January 2020

published in

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volume

102

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page(s)

8132-8137

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issue

23

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Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption

12 January 2020

cites work

1 reference

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Pharmacology and therapeutics of ezetimibe (SCH 58235), a cholesterol-absorption inhibitor

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Efficacy and safety of a potent new selective cholesterol absorption inhibitor, ezetimibe, in patients with primary hypercholesterolemia

19 March 2017

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Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters

19 March 2017

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A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

19 March 2017

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

19 March 2017

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19 March 2017

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Beta-lactam cholesterol absorption inhibitors

22 April 2017

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RETRACTED: Annexin 2-caveolin 1 complex is a target of ezetimibe and regulates intestinal cholesterol transport

29 September 2017

1 reference

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The discovery of ezetimibe: a view from outside the receptor

29 September 2017

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Effects of ezetimibe, a new cholesterol absorption inhibitor, on plasma lipids in patients with primary hypercholesterolemia

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The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption.

29 September 2017

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Multidrug permeases and subcellular cholesterol transport

29 September 2017

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Evidence for a Niemann-pick C (NPC) gene family: identification and characterization of NPC1L1.

29 September 2017

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Intestinal bile acid absorption. Na(+)-dependent bile acid transport activity in rabbit small intestine correlates with the coexpression of an integral 93-kDa and a peripheral 14-kDa bile acid-binding membrane protein along the duodenum-ileum axis

29 September 2017

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Biomedicine. Will the real cholesterol transporter please stand up.

29 September 2017

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Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis

3 June 2018

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Effectiveness and tolerability of ezetimibe in patients with primary hypercholesterolemia: pooled analysis of two phase II studies

21 January 2018

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Efficacy and safety of ezetimibe added to ongoing statin therapy for treatment of patients with primary hypercholesterolemia

21 January 2018

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Efficacy and safety of ezetimibe coadministered with lovastatin in primary hypercholesterolemia

21 January 2018

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Efficacy and safety of ezetimibe coadministered with pravastatin in patients with primary hypercholesterolemia: a prospective, randomized, double-blind trial

21 January 2018

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21 January 2018

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Effect of ezetimibe coadministered with atorvastatin in 628 patients with primary hypercholesterolemia: a prospective, randomized, double-blind trial

21 January 2018

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Synthesis of fluorescent biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors.

21 January 2018

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Ezetimibe, a potent cholesterol absorption inhibitor, inhibits the development of atherosclerosis in ApoE knockout mice

21 January 2018

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Aminopeptidase N (CD13) is a molecular target of the cholesterol absorption inhibitor ezetimibe in the enterocyte brush border membrane

21 January 2018

1 reference

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21 January 2018

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12 December 2020

A retinyl ester hydrolase activity intrinsic to the brush border membrane of rat small intestine

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12 December 2020

In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461

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Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0500269102

2 references

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12 January 2020

ADS bibcode

2005PNAS..102.8132G

0 references

1 reference

2 references

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12 January 2020

2 references