Biosynthesis of carbapenem antibiotics: new carbapenam substrates for carbapenem synthase (CarC). (Q44918723)

7 December 2017

Biosynthesis of carbapenem antibiotics: new carbapenam substrates for carbapenem synthase (CarC). (English)

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(3S,5S)-carbapenam-3-carboxylate

7 December 2017

carbapenem antibiotic

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antibiotic

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(5R)-carbapenem-3-carboxylate

ChEBI release 2020-05-28

ChEBI ID

73939

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ChEBI release 2020-05-28

ChEBI ID

73943

author

Christopher J. Schofield

6

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7 December 2017

Barrie Kellam

3

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author name string

Mark C Sleeman

1

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7 December 2017

Paul Smith

2

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7 December 2017

Siri Ram Chhabra

4

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7 December 2017

Barrie W Bycroft

5

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7 December 2017

1 June 2004

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7 December 2017

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7 December 2017

5

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7 December 2017

6

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7 December 2017

879-882

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Carbapenemases: a problem in waiting?

7 December 2017

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200300908

Analysis of the carbapenem gene cluster of Erwinia carotovora: definition of the antibiotic biosynthetic genes and evidence for a novel beta-lactam resistance mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200300908

The Biosynthetic Gene Cluster for the β-Lactam Carbapenem Thienamycin in Streptomyces cattleya

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200300908

Identification, characterization, and regulation of a cluster of genes involved in carbapenem biosynthesis in Photorhabdus luminescens

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200300908

Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional alpha-KG-dependent non-heme iron enzyme: correlation with mechanisms and reactivities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200300908

Crystal structure of carbapenem synthase (CarC)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200300908

Carbapenem biosynthesis: confirmation of stereochemical assignments and the role of CarC in the ring stereoinversion process from L-proline

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200300908

Inhibition and alternate substrate studies on the mechanism of carbapenam synthetase from Erwinia carotovora

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200300908

Enantiopure synthesis of all four stereoisomers of carbapenam-3-carboxylic acid methyl ester.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200300908

Crystal structure of mycothiol synthase (Rv0819) fromMycobacterium tuberculosisshows structural homology to the GNAT family of N-acetyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200300908

Synthesis of (3S,5R)-carbapenam-3-carboxylic acid and its role in carbapenem biosynthesis and the stereoinversion problem

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200300908

Carboxymethylproline synthase (CarB), an unusual carbon-carbon bond-forming enzyme of the crotonase superfamily involved in carbapenem biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200300908

Immobilized porcine liver esterase: a convenient reagent for the preparation of chiral building blocks

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200300908

21 January 2018

Identifiers

DOI

10.1002/CBIC.200300908

1 reference

7 December 2017

1 reference