Alpha-methylacyl-CoA racemase--an 'obscure' metabolic enzyme takes centre stage (Q34750699)

4 August 2017

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title

Alpha-methylacyl-CoA racemase--an 'obscure' metabolic enzyme takes centre stage (English)

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4 August 2017

3

Anthony S Wierzbicki

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4 August 2017

Matthew D Lloyd

1

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4 August 2017

Daniel J Darley

series ordinal

2

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4 August 2017

Michael D Threadgill

series ordinal

4

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4 August 2017

language of work or name

English

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publication date

12 February 2008

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4 August 2017

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4 August 2017

275

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4 August 2017

6

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4 August 2017

1089-1102

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The chemical biology of branched-chain lipid metabolism

4 August 2017

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Refsum's disease: a peroxisomal disorder affecting phytanic acid alpha-oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Phytanic acid alpha-oxidation, new insights into an old problem: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Human metabolism of phytanic acid and pristanic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Peroxisomes in lipid metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Peroxisome biogenesis disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Peroxisomal disorders: the single peroxisomal enzyme deficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Phytanic acid, AMACR and prostate cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Alpha-methylacyl CoA racemase (P504S): overview and potential uses in diagnostic pathology as applied to prostate needle biopsies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Structure-function analysis of phytanoyl-CoA 2-hydroxylase mutations causing Refsum's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

PTS2 co-receptors: diverse proteins with common features

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Studies on the specificity of unprocessed and mature forms of phytanoyl-CoA 2-hydroxylase and mutation of the iron binding ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

The iron(II) and 2-oxoacid-dependent dioxygenases and their role in metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Further studies on the substrate spectrum of phytanoyl-CoA hydroxylase: implications for Refsum disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: a revised pathway for the alpha-oxidation of straight chain fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Utilization of sterol carrier protein-2 by phytanoyl-CoA 2-hydroxylase in the peroxisomal alpha oxidation of phytanic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

A novel assay for the prenatal diagnosis of Sjögren-Larsson syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Assay for Sjögren-Larsson syndrome based on a deficiency of phytol degradation.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Identification of fatty aldehyde dehydrogenase in the breakdown of phytol to phytanic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Characterization of the final step in the conversion of phytol into phytanic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Phytanic acid: production from phytol, its breakdown and role in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Inherited disorders of fatty alcohol metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Characterisation of recombinant human fatty aldehyde dehydrogenase: implications for Sjögren-Larsson syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Clinical significance of oxidation from phytol to phytanic acid in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Involvement of microsomal fatty aldehyde dehydrogenase in the alpha-oxidation of phytanic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Identification of pristanal dehydrogenase activity in peroxisomes: conclusive evidence that the complete phytanic acid alpha-oxidation pathway is localized in peroxisomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Genomic organization, expression, and alternate splicing of the mouse fatty aldehyde dehydrogenase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Dual subcellular localization in the endoplasmic reticulum and peroxisomes and a vital role in protecting against oxidative stress of fatty aldehyde dehydrogenase are achieved by alternative splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Peroxisome proliferator-activated receptor alpha plays a vital role in inducing a detoxification system against plant compounds with crosstalk with other xenobiotic nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Metabolism of phytanic acid and 3-methyl-adipic acid excretion in patients with adult Refsum disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Omega-hydroxylation of phytanic acid in rat liver microsomes: implications for Refsum disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Characterization of phytanic acid omega-hydroxylation in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

CYP4 isoform specificity in the omega-hydroxylation of phytanic acid, a potential route to elimination of the causative agent of Refsum's disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Peroxisomes and bile acid biosynthesis.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Stereochemistry of peroxisomal and mitochondrial beta-oxidation of alpha-methylacyl-CoAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Fibroblast studies documenting a case of peroxisomal 2-methylacyl-CoA racemase deficiency: possible link between racemase deficiency and malabsorption and vitamin K deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Mutations in the gene encoding peroxisomal alpha-methylacyl-CoA racemase cause adult-onset sensory motor neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

A mouse model for alpha-methylacyl-CoA racemase deficiency: adjustment of bile acid synthesis and intolerance to dietary methyl-branched lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

A 13C NMR study on ibuprofen metabolism in isolated rat liver mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

The role of coenzyme A in the biotransformation of 2-arylpropionic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Metabolic stereoisomeric inversion of ibuprofen in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

P504S: a new molecular marker for the detection of prostate carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Expression of α-methylacyl-coa racemase (p504s) in various malignant neoplasms and normal tissues: a study of 761 cases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Expression of alpha-Methylacyl-CoA racemase (P504S) in atypical adenomatous hyperplasia of the prostate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Molecular features of the transition from prostatic intraepithelial neoplasia (PIN) to prostate cancer: genome-wide gene-expression profiles of prostate cancers and PINs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Alpha-methylacyl-CoA racemase protein expression is associated with the degree of differentiation in breast cancer using quantitative image analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Messenger RNA expression ratios among four genes predict subtypes of renal cell carcinoma and distinguish oncocytoma from carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Abundant expression of AMACR in many distinct tumour types

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Serum levels of phytanic acid are associated with prostate cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Elevated alpha-methylacyl-CoA racemase enzymatic activity in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Peroxisomal branched chain fatty acid beta-oxidation pathway is upregulated in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Alternative spliced variants of the alpha-methylacyl-CoA racemase gene and their expression in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

In mouse alpha -methylacyl-CoA racemase, the same gene product is simultaneously located in mitochondria and peroxisomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Purification and properties of an alpha-methylacyl-CoA racemase from rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Purification and characterization of an alpha-methylacyl-CoA racemase from human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Proton transfer at carbon.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Alpha-methylacyl-CoA racemase from Mycobacterium tuberculosis. Mutational and structural characterization of the active site and the fold

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

The catalysis of the 1,1-proton transfer by alpha-methyl-acyl-CoA racemase is coupled to a movement of the fatty acyl moiety over a hydrophobic, methionine-rich surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

A new family of CoA-transferases

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

The crystal structure of the Escherichia coli YfdW gene product reveals a new fold of two interlaced rings identifying a wide family of CoA transferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Kinetic and mechanistic characterization of the formyl-CoA transferase from Oxalobacter formigenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Crystal structure of fatty acid-CoA racemase from Mycobacterium tuberculosis H37Rv.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Peroxisomes and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Protective effects of ibuprofen and its major metabolites against in vitro inactivation of catalase and fumarase: relevance to cataract

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha - and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Phytanoyl-CoA hydroxylase activity is induced by phytanic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Very-long-chain and branched-chain fatty acyl-CoAs are high affinity ligands for the peroxisome proliferator-activated receptor alpha (PPARalpha).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Peroxisome proliferator-activated receptor alpha interacts with high affinity and is conformationally responsive to endogenous ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Phytanic acid activates the peroxisome proliferator-activated receptor alpha (PPARalpha) in sterol carrier protein 2-/ sterol carrier protein x-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Metabolism of phytol to phytanic acid in the mouse, and the role of PPARalpha in its regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Phytol directly activates peroxisome proliferator-activated receptor alpha (PPARalpha) and regulates gene expression involved in lipid metabolism in PPARalpha-expressing HepG2 hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

A phytol-enriched diet induces changes in fatty acid metabolism in mice both via PPARalpha-dependent and -independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

The chlorophyll metabolite phytanic acid is a natural rexinoid--potential for treatment and prevention of diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Phytanic acid is a retinoid X receptor ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Phytol metabolites are circulating dietary factors that activate the nuclear receptor RXR

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Phytanic acid, a novel activator of uncoupling protein-1 gene transcription and brown adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

The evolving biology and treatment of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

The metabolism of phytanic acid and pristanic acid in man: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Diet and Refsum's disease. The determination of phytanic acid and phytol in certain foods and the application of this knowledge to the choice of suitable convenience foods for patients with Refsum's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Chiral inversion of 2-arylpropionic acid non-steroidal anti-inflammatory drugs—II Racemization and hydrolysis of (R)- and (S)-ibuprofen-CoA thioesters

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Sequence variation in α-methylacyl-CoA racemase and risk of early-onset and familial prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

Variants in the -Methylacyl-CoA Racemase Gene and the Association with Advanced Distal Colorectal Adenoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2008.06290.X

10.1111/J.1742-4658.2008.06290.X

21 January 2018

Identifiers

DOI

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4 August 2017

1 reference