Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers. (Q34995420)

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English	Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers.	scientific article

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22 February 2020

Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers (English)

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22 February 2020

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neurodegeneration

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based on heuristic

inferred from title

1

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22 February 2020

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Sovan Sarkar

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5 August 2017

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1 October 2013

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22 February 2020

Biochemical Society Transactions

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22 February 2020

1103-1130

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22 February 2020

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22 February 2020

Regulation of mammalian autophagy in physiology and pathophysiology.

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21 January 2018

Loss of autophagy in the central nervous system causes neurodegeneration in mice

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21 January 2018

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

1 reference

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21 January 2018

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

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21 January 2018

Autophagy is required to maintain muscle mass.

1 reference

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21 January 2018

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

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21 January 2018

The role of autophagy during the early neonatal starvation period

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21 January 2018

Autophagy fights disease through cellular self-digestion

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21 January 2018

Signalling and autophagy regulation in health, aging and disease

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21 January 2018

Autophagy: dual roles in life and death?

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21 January 2018

Autophagy in cell death: an innocent convict?

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21 January 2018

Autophagosomes form at ER-mitochondria contact sites

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21 January 2018

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

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21 January 2018

3D tomography reveals connections between the phagophore and endoplasmic reticulum

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21 January 2018

Plasma membrane contributes to the formation of pre-autophagosomal structures

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21 January 2018

Mitochondria supply membranes for autophagosome biogenesis during starvation

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21 January 2018

Isolation and characterization of rat liver amphisomes. Evidence for fusion of autophagosomes with both early and late endosomes.

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21 January 2018

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

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21 January 2018

Unveiling the roles of autophagy in innate and adaptive immunity

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21 January 2018

A role for NBR1 in autophagosomal degradation of ubiquitinated substrates

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21 January 2018

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

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21 January 2018

Autophagy regulates lipid metabolism

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21 January 2018

The role of lipids in the control of autophagy

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21 January 2018

Mechanisms of mitophagy

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21 January 2018

Chaperone-mediated autophagy: a unique way to enter the lysosome world

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21 January 2018

Microautophagy in mammalian cells: revisiting a 40-year-old conundrum

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21 January 2018

A Unified Nomenclature for Yeast Autophagy-Related Genes

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21 January 2018

A comprehensive glossary of autophagy-related molecules and processes

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21 January 2018

Molecular dissection of autophagy: two ubiquitin-like systems

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21 January 2018

A protein conjugation system essential for autophagy

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21 January 2018

Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

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21 January 2018

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

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21 January 2018

LC3 conjugation system in mammalian autophagy

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21 January 2018

Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion

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21 January 2018

HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates

1 reference

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21 January 2018

The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy

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21 January 2018

Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells

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21 January 2018

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

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21 January 2018

Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG

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21 January 2018

Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network

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21 January 2018

Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase

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21 January 2018

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

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21 January 2018

Induction of autophagy and inhibition of tumorigenesis by beclin 1

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21 January 2018

The Beclin 1 interactome

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21 January 2018

The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function

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21 January 2018

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

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21 January 2018

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.

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21 January 2018

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

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21 January 2018

Bim inhibits autophagy by recruiting Beclin 1 to microtubules

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21 January 2018

Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1

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21 January 2018

Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease

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21 January 2018

3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

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21 January 2018

Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

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21 January 2018

The role of the Atg1/ULK1 complex in autophagy regulation

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21 January 2018

Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes

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21 January 2018

Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC

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21 January 2018

The itinerary of autophagosomes: from peripheral formation to kiss-and-run fusion with lysosomes

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21 January 2018

Dynein-dependent movement of autophagosomes mediates efficient encounters with lysosomes

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21 January 2018

Dynein mutations impair autophagic clearance of aggregate-prone proteins

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21 January 2018

Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes

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21 January 2018

Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases

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21 January 2018

Role for Rab7 in maturation of late autophagic vacuoles

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21 January 2018

Molecular basis of physiological heart growth: fundamental concepts and new players

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21 January 2018

Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers

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21 January 2018

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex

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21 January 2018

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease

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21 January 2018

ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration

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21 January 2018

ESCRT functions in autophagy and associated disease

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21 January 2018

The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes

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21 January 2018

TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways.

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21 January 2018

Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events.

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21 January 2018

Autophagic substrate clearance requires activity of the syntaxin-5 SNARE complex

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21 January 2018

Microtubules support production of starvation-induced autophagosomes but not their targeting and fusion with lysosomes.

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21 January 2018

Network organization of the human autophagy system

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21 January 2018

mTOR signaling in growth control and disease

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21 January 2018

mTOR: from growth signal integration to cancer, diabetes and ageing

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21 January 2018

Autophagy as a regulated pathway of cellular degradation

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21 January 2018

Rapamycin passes the torch: a new generation of mTOR inhibitors

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21 January 2018

Rapamycin alleviates toxicity of different aggregate-prone proteins

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21 January 2018

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

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21 January 2018

Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast

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21 January 2018

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

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21 January 2018

Rapamycin inhibits mTORC1, but not completely.

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21 January 2018

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

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21 January 2018

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

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21 January 2018

Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor

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21 January 2018

Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.

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21 January 2018

Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling

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21 January 2018

Small molecule regulators of autophagy identified by an image-based high-throughput screen

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21 January 2018

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

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21 January 2018

Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain

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21 January 2018

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

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21 January 2018

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

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21 January 2018

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

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21 January 2018

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

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21 January 2018

siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy

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21 January 2018

Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism

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21 January 2018

Amino acid regulation of autophagosome formation

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Amino acid signalling upstream of mTOR

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21 January 2018

Bidirectional transport of amino acids regulates mTOR and autophagy

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

1 reference

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21 January 2018

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

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21 January 2018

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

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21 January 2018

Regulation of TORC1 by Rag GTPases in nutrient response

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21 January 2018

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

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21 January 2018

TFEB links autophagy to lysosomal biogenesis

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21 January 2018

The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis

1 reference

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21 January 2018

Lysosomal positioning coordinates cellular nutrient responses.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Termination of autophagy and reformation of lysosomes regulated by mTOR

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https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.

1 reference

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21 January 2018

The phosphoinositide 3-kinase pathway

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21 January 2018

The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway

1 reference

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21 January 2018

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

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21 January 2018

Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.

1 reference

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21 January 2018

Rheb fills a GAP between TSC and TOR.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

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21 January 2018

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

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https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells

1 reference

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21 January 2018

FoxO3 controls autophagy in skeletal muscle in vivo

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Role and regulation of starvation-induced autophagy in the Drosophila fat body

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21 January 2018

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

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21 January 2018

The LKB1 tumor suppressor negatively regulates mTOR signaling

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21 January 2018

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

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21 January 2018

TSC2 mediates cellular energy response to control cell growth and survival

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

AMPK phosphorylation of raptor mediates a metabolic checkpoint

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Antagonistic controls of autophagy and glycogen accumulation by Snf1p, the yeast homolog of AMP-activated protein kinase, and the cyclin-dependent kinase Pho85p

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

AMP-activated Protein Kinase and the Regulation of Autophagic Proteolysis

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy

1 reference

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21 January 2018

Complex inhibitory effects of nitric oxide on autophagy

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21 January 2018

The IKK complex contributes to the induction of autophagy

1 reference

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21 January 2018

Regulation of autophagy by cytoplasmic p53

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200.

1 reference

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21 January 2018

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L.

1 reference

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21 January 2018

Lithium induces autophagy by inhibiting inositol monophosphatase

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21 January 2018

Inositol trisphosphate and calcium signalling

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21 January 2018

Inositol phosphate biochemistry

1 reference

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21 January 2018

A common mechanism of action for three mood-stabilizing drugs

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Valproate decreases inositol biosynthesis

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

The calpain system

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Persistent activation of Gsalpha through limited proteolysis by calpain

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Epac: defining a new mechanism for cAMP action

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Calcium signalling: dynamics, homeostasis and remodelling

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Regulation of macroautophagy by mTOR and Beclin 1 complexes

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

BH3 mimetics activate multiple pro-autophagic pathways

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Identification of a candidate therapeutic autophagy-inducing peptide

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Role of trehalose phosphate synthase and trehalose during hypoxia: from flies to mammals

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

The roles of intracellular protein-degradation pathways in neurodegeneration

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Protein aggregation and neurodegenerative disease

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Glutamine repeats and neurodegeneration

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

A century-old debate on protein aggregation and neurodegeneration enters the clinic

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Pathogenesis of polyglutamine disorders: aggregation revisited

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Repeat expansion disease: progress and puzzles in disease pathogenesis

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Polyglutamine neurodegeneration: expanded glutamines enhance native functions

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

p62/SQSTM1-dependent autophagy of Lewy body-like α-synuclein inclusions

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Early accumulation of p62 in neurofibrillary tangles in Alzheimer's disease: possible role in tangle formation.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Huntington's disease: degradation of mutant huntingtin by autophagy

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Degradation of Amyotrophic Lateral Sclerosis-linked Mutant Cu,Zn-Superoxide Dismutase Proteins by Macroautophagy and the Proteasome

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Autophagic clearance of aggregate-prone proteins associated with neurodegeneration.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Autophagy modulation as a potential therapeutic target for diverse diseases

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Chemical modulators of autophagy as biological probes and potential therapeutics

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Impairment of the ubiquitin-proteasome system by protein aggregation

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Aggregate formation inhibits proteasomal degradation of polyglutamine proteins.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Autophagy regulates the processing of amino terminal huntingtin fragments

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

mTOR and the control of whole body metabolism

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Chemical screening platforms for autophagy drug discovery to identify therapeutic candidates for Huntington's disease and other neurodegenerative disorders.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Small molecule enhancers of autophagy for neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Protein misfolding disorders and macroautophagy

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Autophagy and polyglutamine diseases

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics, and neuronal synaptic damage in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Calcium dysregulation and homeostasis of neural calcium in the molecular mechanisms of neurodegenerative diseases provide multiple targets for neuroprotection

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Rapamycin pre-treatment protects against apoptosis

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Inhibition of macroautophagy triggers apoptosis

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Frontotemporal dementia: implications for understanding Alzheimer disease

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Presenilin: running with scissors in the membrane

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Autophagy enhancer carbamazepine alleviates memory deficits and cerebral amyloid-β pathology in a mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Trehalose protects from aggravation of amyloid pathology induced by isoflurane anesthesia in APP(swe) mutant mice.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Autophagic degradation of tau in primary neurons and its enhancement by trehalose.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Long-term oral lithium treatment attenuates motor disturbance in tauopathy model mice: implications of autophagy promotion

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Parkinson's disease

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Recent advances in the genetics of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

100 years of Lewy pathology.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Genomic investigation of alpha-synuclein multiplication and parkinsonism

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

α-Synuclein impairs macroautophagy: implications for Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Alpha-synuclein overexpression promotes aggregation of mutant huntingtin

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

α-Synuclein levels modulate Huntington's disease in mice

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

DJ-1, PINK1, and their effects on mitochondrial pathways

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

The PINK1/Parkin pathway regulates mitochondrial morphology

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Interplay of LRRK2 with chaperone-mediated autophagy

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

alpha-Synucleinopathy models and human neuropathology: similarities and differences

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Huntington's disease: from pathology and genetics to potential therapies

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Lessons from animal models of Huntington's disease

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Hereditary parkinsonism: Parkinson disease look-alikes--an algorithm for clinicians to "PARK" genes and beyond

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Identification of genes that modify ataxin-1-induced neurodegeneration.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Differential degradation of full-length and cleaved ataxin-7 fragments in a novel stable inducible SCA7 model

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Inhibition of autophagy via p53-mediated disruption of ULK1 in a SCA7 polyglutamine disease model.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Development of Purkinje cell degeneration in a knockin mouse model reveals lysosomal involvement in the pathogenesis of SCA6.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

p62/SQSTM1 differentially removes the toxic mutant androgen receptor via autophagy and inclusion formation in a spinal and bulbar muscular atrophy mouse model.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

17-AAG increases autophagic removal of mutant androgen receptor in spinal and bulbar muscular atrophy.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Autophagy-related proteins (p62, NBR1 and LC3) in intranuclear inclusions in neurodegenerative diseases.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Neurodegeneration by polyglutamine Atrophin is not rescued by induction of autophagy.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Mutations in dynein link motor neuron degeneration to defects in retrograde transport

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Mutant dynactin in motor neuron disease.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS).

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

SKD1 AAA ATPase-dependent endosomal transport is involved in autolysosome formation

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Lithium delays progression of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

No benefit from chronic lithium dosing in a sibling-matched, gender balanced, investigator-blinded trial using a standard mouse model of familial ALS

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Lithium carbonate in amyotrophic lateral sclerosis: lack of efficacy in a dose-finding trial

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Lithium in patients with amyotrophic lateral sclerosis (LiCALS): a phase 3 multicentre, randomised, double-blind, placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Progressive myoclonic epilepsies: a review of genetic and therapeutic aspects

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Lafora progressive myoclonus epilepsy: a meta-analysis of reported mutations in the first decade following the discovery of the EPM2A and NHLRC1 genes

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Laforin, the most common protein mutated in Lafora disease, regulates autophagy

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Lafora bodies and neurological defects in malin-deficient mice correlate with impaired autophagy

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis.

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Autophagy induction by trehalose counteracts cellular prion infection

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Induction of autophagy by spermidine promotes longevity

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Autophagy as a target for anticancer therapy

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

How many drug targets are there?

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Technical challenges in using human induced pluripotent stem cells to model disease

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

How do ESCRT proteins control autophagy?

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Autophagy is defective in collagen VI muscular dystrophies and its reactivation rescues myofiber degeneration

1 reference

https://api.crossref.org/works/10.1042%2FBST20130134

21 January 2018

Identifiers

10.1042/BST20130134

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24059496%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24059496%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

ResearchGate publication ID

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