Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. (Q45303665)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17182613%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

title

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein (English)

1 reference

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23 December 2019

main subject

alpha,alpha-trehalose

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4

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23 December 2019

Sovan Sarkar

1

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23 December 2019

author name string

Janet E Davies

2

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23 December 2019

Zebo Huang

3

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23 December 2019

David C Rubinsztein

5

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23 December 2019

language of work or name

English

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publication date

20 December 2006

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17182613%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

23 December 2019

number of pages

12

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based on heuristic

inferred from page(s)

published in

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23 December 2019

volume

282

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23 December 2019

page(s)

5641-5652

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23 December 2019

issue

8

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Role of trehalose phosphate synthase and trehalose during hypoxia: from flies to mammals

23 December 2019

cites work

1 reference

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Yeast adapt to near-freezing temperatures by STRE/Msn2,4-dependent induction of trehalose synthesis and certain molecular chaperones

21 January 2018

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Human platelets loaded with trehalose survive freeze-drying

21 January 2018

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Influence of molecular and chemical chaperones on protein folding

21 January 2018

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Inhibition of insulin amyloid formation by small stress molecules

21 January 2018

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Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42.

21 January 2018

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Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

21 January 2018

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Lessons from animal models of Huntington's disease

21 January 2018

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Rapamycin alleviates toxicity of different aggregate-prone proteins

21 January 2018

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Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

21 January 2018

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

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α-Synuclein Is Degraded by Both Autophagy and the Proteasome

21 January 2018

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Lithium induces autophagy by inhibiting inositol monophosphatase

21 January 2018

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Autophagy as a regulated pathway of cellular degradation

21 January 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

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A molecular investigation of true dominance in Huntington's disease

21 January 2018

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The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/lysosomes

21 January 2018

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Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

21 January 2018

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Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease

21 January 2018

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Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin

21 January 2018

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Intracellular trehalose improves osmotolerance but not desiccation tolerance in mammalian cells

21 January 2018

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

21 January 2018

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Methods for monitoring autophagy

21 January 2018

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HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates

21 January 2018

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Rapamycin pre-treatment protects against apoptosis

21 January 2018

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Expression of Drosophila trehalose-phosphate synthase in HEK-293 cells increases hypoxia tolerance

21 January 2018

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TOR, a central controller of cell growth

21 January 2018

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Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy

21 January 2018

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Cloning, characterization and mapping of the mouse trehalase (Treh) gene

21 January 2018

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Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages

21 January 2018

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Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy

21 January 2018

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Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation

21 January 2018

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Nuclear inclusions in oculopharyngeal muscular dystrophy consist of poly(A) binding protein 2 aggregates which sequester poly(A) RNA

21 January 2018

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

1 reference

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Loading Human Mesenchymal Stem Cells with Trehalose by Fluid-Phase Endocytosis

21 January 2018

1 reference

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Temperature dependence of fluid phase endocytosis coincides with membrane properties of pig platelets

21 January 2018

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Capture and processing of exogenous antigens for presentation on MHC molecules.

21 January 2018

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Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes

21 January 2018

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Bioplex technology: novel synthetic gene delivery pharmaceutical based on peptides anchored to nucleic acids

21 January 2018

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The roles of intracellular protein-degradation pathways in neurodegeneration

21 January 2018

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How understanding the control of energy metabolism can help investigation of mitochondrial dysfunction, regulation and pharmacology

21 January 2018

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Autophagy defends cells against invading group A Streptococcus

21 January 2018

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Escape of intracellular Shigella from autophagy

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M609532200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17182613%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

1 reference