Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein. (Q33594388)

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16 January 2020

title

Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein (English)

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16 January 2020

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16 January 2020

Zheng Li

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Huaibin Cai

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16 January 2020

author name string

Xian Lin

1

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16 January 2020

Loukia Parisiadou

2

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Lizhen Wang

4

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Hoon Shim

5

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16 January 2020

Lixin Sun

6

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16 January 2020

Chengsong Xie

7

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Cai-Xia Long

8

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Wan-Jou Yang

9

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Jinhui Ding

10

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16 January 2020

Zsu Zsu Chen

11

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Paul E Gallant

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Jung-Hwa Tao-Cheng

13

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Gay Rudow

14

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16 January 2020

Juan C Troncoso

15

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16 January 2020

Zhihua Liu

16

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16 January 2020

language of work or name

English

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publication date

1 December 2009

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16 January 2020

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16 January 2020

volume

64

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issue

6

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16 January 2020

page(s)

807-827

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R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.

16 January 2020

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Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

21 June 2018

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The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules

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Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants

21 June 2018

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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

21 June 2018

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Impairment of microtubule-dependent trafficking by overexpression of alpha-synuclein

21 June 2018

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21 June 2018

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21 June 2018

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Kinase activity of mutant LRRK2 mediates neuronal toxicity

21 June 2018

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Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

21 June 2018

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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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30 October 2018

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30 October 2018

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30 October 2018

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Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion

30 October 2018

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Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

30 October 2018

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Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

30 October 2018

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30 October 2018

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A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations

30 October 2018

1 reference

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Genetics of Parkinson's disease

30 October 2018

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12 December 2020

Role of microtubules in the organization of the Golgi complex

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12 December 2020

Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

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12 December 2020

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12 December 2020

Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease

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12 December 2020

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Identifiers

DOI

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16 January 2020

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16 January 2020

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