Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. (Q21135493)

22 June 2017

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. (English)

1 reference

22 June 2017

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1 reference

1 reference

18

Dagmar Galter

Dagmar

Galter

1 reference

16 August 2022

20

Michael K Lee

Michael K

Lee

1 reference

16 August 2022

22

Valina L Dawson

Valina L

Dawson

1 reference

16 August 2022

David Ramonet

1

David

Ramonet

1 reference

16 August 2022

17

Neal G Copeland

Neal G

Copeland

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22 June 2017

16

Nancy A Jenkins

Nancy A

Jenkins

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22 June 2017

21

Ted M Dawson

Ted M

Dawson

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22 June 2017

13

M Flint Beal

M Flint

Beal

1 reference

22 June 2017

9

Liliane

Glauser

Liliane Glauser

1 reference

22 June 2017

4

Klodjan

Stafa

Klodjan Stafa

1 reference

22 June 2017

23

Darren J

Moore

Darren J Moore

1 reference

22 June 2017

João Paulo L Daher

2

João Paulo L

Daher

1 reference

22 June 2017

Brian M Lin

3

Brian M

Lin

1 reference

22 June 2017

Jaekwang Kim

5

Jaekwang

Kim

1 reference

22 June 2017

Rebecca Banerjee

6

Rebecca

Banerjee

1 reference

22 June 2017

Marie Westerlund

7

Marie

Westerlund

1 reference

22 June 2017

Olga Pletnikova

8

Olga

Pletnikova

1 reference

22 June 2017

Lichuan Yang

10

Lichuan

Yang

1 reference

22 June 2017

Ying Liu

11

Ying

Liu

1 reference

22 June 2017

Deborah A Swing

12

Deborah A

Swing

1 reference

22 June 2017

Juan C Troncoso

14

Juan C

Troncoso

1 reference

22 June 2017

J Michael McCaffery

15

J Michael

McCaffery

1 reference

22 June 2017

Bobby Thomas

19

Bobby

Thomas

1 reference

22 June 2017

language of work or name

English

0 references

publication date

6 April 2011

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22 June 2017

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22 June 2017

6

1 reference

22 June 2017

e18568

1 reference

22 June 2017

4

1 reference

Creative Commons Attribution 4.0 International

22 June 2017

start time

6 April 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3071839/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

19 March 2017

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Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

19 March 2017

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OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion

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A common LRRK2 mutation in idiopathic Parkinson's disease

19 March 2017

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

19 March 2017

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Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S

19 March 2017

1 reference

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Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

19 March 2017

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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

7 April 2017

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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

7 April 2017

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Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

7 April 2017

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12 September 2017

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Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).

12 September 2017

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Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

12 September 2017

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Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.

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R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.

12 September 2017

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Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons

12 September 2017

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LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans

12 September 2017

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Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions

12 September 2017

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Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

12 September 2017

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12 September 2017

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The biology and pathobiology of LRRK2: implications for Parkinson's disease

12 September 2017

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Value of genetic models in understanding the cause and mechanisms of Parkinson's disease

12 September 2017

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The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

12 September 2017

1 reference

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A Drosophila model for LRRK2-linked parkinsonism

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071839

Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons

12 September 2017

1 reference

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Parkin mediates the degradation-independent ubiquitination of Hsp70

12 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071839

Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071839

The family of sensorimotor gating disorders: comorbidities or diagnostic overlaps?

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071839

An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071839

Biochemical and pathological characterization of Lrrk2.

12 September 2017

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CMV enhancer/human PDGF-beta promoter for neuron-specific transgene expression

27 September 2017

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New stereological methods for counting neurons

27 September 2017

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Localization of GTPases by indirect immunofluorescence and immunoelectron microscopy

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071839

LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews.

27 September 2017

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018568

LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018568

Improved neuronal transgene expression from an AAV-2 vector with a hybrid CMV enhancer/PDGF-beta promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018568

A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018568

Lrrk2 and Lewy body disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018568

LRRK2 expression linked to dopamine-innervated areas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018568

Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018568

Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018568

Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018568

LRRK2G2019S as a Cause of Parkinson's Disease in North African Arabs

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018568

Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071839

The Parkinson disease gene LRRK2: evolutionary and structural insights

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21494637

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21494637

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0018568

1 reference

OpenCitations bibliographic resource ID

22 June 2017

0 references

2736877

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference