Differential degradation of full-length and cleaved ataxin-7 fragments in a novel stable inducible SCA7 model (Q42177883)

18 October 2017

Differential degradation of full-length and cleaved ataxin-7 fragments in a novel stable inducible SCA7 model (English)

1 reference

18 October 2017

Xin Yu

1

1 reference

18 October 2017

Abiodun Ajayi

series ordinal

2

1 reference

18 October 2017

Narasimha Rao Boga

series ordinal

3

1 reference

18 October 2017

Anna-Lena Ström

series ordinal

4

1 reference

18 October 2017

25 February 2012

1 reference

Journal of Molecular Neuroscience

18 October 2017

1 reference

18 October 2017

47

1 reference

18 October 2017

219-233

1 reference

18 October 2017

2

1 reference

https://scigraph.springernature.com/pub.10.1007/s12031-012-9722-8

18 October 2017

0 references

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Integration of clearance mechanisms: the proteasome and autophagy

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Histone acetylation, acetyltransferases, and ataxia--alteration of histone acetylation and chromatin dynamics is implicated in the pathogenesis of polyglutamine-expansion disorders

26 October 2017

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Autophagy gone awry in neurodegenerative diseases

26 October 2017

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Neurotoxic protein oligomerisation associated with polyglutamine diseases

26 October 2017

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Methods in mammalian autophagy research

26 October 2017

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Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3

26 October 2017

1 reference

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Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment

26 October 2017

1 reference

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Intranuclear degradation of polyglutamine aggregates by the ubiquitin-proteasome system.

26 October 2017

1 reference

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Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

26 October 2017

1 reference

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Proteasomes cleave at multiple sites within polyglutamine tracts: activation by PA28gamma(K188E).

26 October 2017

1 reference

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Autophagy fights disease through cellular self-digestion

26 October 2017

1 reference

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Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration

26 October 2017

1 reference

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Inefficient degradation of truncated polyglutamine proteins by the proteasome

26 October 2017

1 reference

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

26 October 2017

1 reference

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

26 October 2017

1 reference

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Recent advances in the identification and development of 20S proteasome inhibitors

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

Cloning and expression analysis of the murine homolog of the spinocerebellar ataxia type 7 (SCA7) gene

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

Impairment of the ubiquitin-proteasome system by protein aggregation

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

Dissection of autophagosome biogenesis into distinct nucleation and expansion steps

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

Clinical features and classification of inherited ataxias.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

Posttranslational modification of ataxin-7 at lysine 257 prevents autophagy-mediated turnover of an N-terminal caspase-7 cleavage fragment

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

A role for both wild-type and expanded ataxin-7 in transcriptional regulation

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

Neurodegeneration by polyglutamine Atrophin is not rescued by induction of autophagy.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

In search of an "autophagomometer".

17 August 2018

1 reference

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Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activation

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

Molecular Genetics and Biomarkers of Polyglutamine Diseases

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

Rapamycin inhibits polyglutamine aggregation independently of autophagy by reducing protein synthesis

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

Global changes to the ubiquitin system in Huntington's disease.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

Proteasome degrades soluble expanded polyglutamine completely and efficiently

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

Autophagy regulates the processing of amino terminal huntingtin fragments

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

SCA7 knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

Aggregate formation inhibits proteasomal degradation of polyglutamine proteins.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

Polyglutamine-expanded ataxin-7 promotes non-cell-autonomous purkinje cell degeneration and displays proteolytic cleavage in ataxic transgenic mice.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

Expression of ataxin-7 in CNS and non-CNS tissue of normal and SCA7 individuals.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360856

SCA7 mouse models show selective stabilization of mutant ataxin-7 and similar cellular responses in different neuronal cell types

17 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS12031-012-9722-8

Nuclear inclusions in Huntington's disease

21 January 2018

1 reference

12 December 2020

Expression analysis of ataxin-7 mRNA and protein in human brain: evidence for a widespread distribution and focal protein accumulation

1 reference

12 December 2020

Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes

1 reference

12 December 2020

Inhibition of protein synthesis separates autophagic sequestration from the delivery of lysosomal enzymes

1 reference

12 December 2020

10.1007/S12031-012-9722-8

Identifiers

DOI

1 reference

Dimensions Publication ID

18 October 2017

0 references

1 reference

18 October 2017

1 reference