PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA--EURL ECVAM ADME workshop. (Q51137886)

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scientific article published on 26 November 2013

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English	PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA--EURL ECVAM ADME workshop.	scientific article published on 26 November 2013

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scholarly article

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http://europepmc.org/abstract/MED/24287156

PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA--EURL ECVAM ADME workshop. (English)

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Jos G Bessems

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Eva-Maria Collnot

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Eva-Maria Collnot

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Ursula Gundert-Remy

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Ursula Gundert-Remy

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Sandra Coecke

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George Loizou

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Kannan Krishnan

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Harvey J Clewell

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Camilla Bernasconi

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Frederic Bois

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Walter Diembeck

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Liesbeth Geraets

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Nynke Kramer

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Gabriele Küsters

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Sofia B Leite

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Olavi R Pelkonen

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Klaus Schröder

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Emanuela Testai

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Iwona Wilk-Zasadna

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José-Manuel Zaldívar-Comenges

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26 November 2013

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Regulatory Toxicology and Pharmacology

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Solubility properties in polymers and biological media. 2. The correlation and prediction of the solubilities of nonelectrolytes in biological tissues and fluids.

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Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers

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Calculating the retention of volatile organic compounds in the lung on the basis of their physicochemical properties.

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A novel strategy for physiologically based predictions of human pharmacokinetics

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An integrated QSPR-PBPK modelling approach for in vitro-in vivo extrapolation of pharmacokinetics in rats

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Computational prediction of metabolism: sites, products, SAR, P450 enzyme dynamics, and mechanisms

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On the recognition of mammalian microsomal cytochrome P450 substrates and their characteristics: towards the prediction of human p450 substrate specificity and metabolism

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Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line

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In vitro and in vivo evaluation of the tissue-to-blood partition coefficient for physiological pharmacokinetic models

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HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro

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https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.11.008

7 January 2021

Drug-protein binding sites. New trends in analytical and experimental methodology

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.11.008

7 January 2021

In vitro-in vivo extrapolation of hepatic clearance: biological tools, scaling factors, model assumptions and correct concentrations

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.11.008

7 January 2021

Canadian house dust study: lead bioaccessibility and speciation.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.11.008

7 January 2021

Recent developments in solid-phase microextraction

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.11.008

7 January 2021

Protocol for solid-phase microextraction method development

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.11.008

7 January 2021

Interindividual variability in gene expression profiles in human hepatocytes and comparison with HepaRG cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.11.008

7 January 2021

Functional expression, inhibition and induction of CYP enzymes in HepaRG cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.11.008

7 January 2021

Solid-phase microextraction in biomedical analysis

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.11.008

7 January 2021

Development and validation of a higher-throughput equilibrium dialysis assay for plasma protein binding.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.11.008

7 January 2021

Validation of a rapid equilibrium dialysis approach for the measurement of plasma protein binding.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.11.008

7 January 2021

Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.11.008

7 January 2021

Identifiers

10.1016/J.YRTPH.2013.11.008

1 reference

Europe PubMed Central

30 March 2018

http://europepmc.org/abstract/MED/24287156

1 reference

Europe PubMed Central

30 March 2018

http://europepmc.org/abstract/MED/24287156

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