Use of human in vitro skin models for accurate and ethical risk assessment: metabolic considerations (Q39173876)

9 September 2017

Use of human in vitro skin models for accurate and ethical risk assessment: metabolic considerations (English)

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9 September 2017

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3

Ellen Fritsche

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9 September 2017

Nicola J Hewitt

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9 September 2017

Robert J Edwards

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9 September 2017

Carsten Goebel

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9 September 2017

Pierre Aeby

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Julia Scheel

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9 September 2017

Kerstin Reisinger

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9 September 2017

Gladys Ouédraogo

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9 September 2017

Daniel Duche

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9 September 2017

Joan Eilstein

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9 September 2017

Alain Latil

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Julia Kenny

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9 September 2017

Claire Moore

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9 September 2017

Jochen Kuehnl

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Joao Barroso

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Rolf Fautz

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Stefan Pfuhler

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28 March 2013

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9 September 2017

Toxicological Sciences

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9 September 2017

133

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2

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209-217

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International prevalidation studies of the EpiDerm 3D human reconstructed skin micronucleus (RSMN) assay: transferability and reproducibility

9 September 2017

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Evaluation of chemicals requiring metabolic activation in the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Characterization of glutathione S-transferase in cultured human keratinocytes

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Exposure of human skin to benzo[a]pyrene: role of CYP1A1 and aryl hydrocarbon receptor in oxidative stress generation.

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymes

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Human cytosolic sulfotransferase 2B1: isoform expression, tissue specificity and subcellular localization

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Role of HuR and p38MAPK in ultraviolet B-induced post-transcriptional regulation of COX-2 expression in the human keratinocyte cell line HaCaT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Further development of the NCTC 2544 IL-18 assay to identify in vitro contact allergens.

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Induction by xenobiotics of phase I and phase II enzyme activities in the human keratinocyte cell line NCTC 2544.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Xenobiotic metabolism capacities of human skin in comparison with a 3D epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: activating enzymes (Phase I).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Xenobiotic metabolism capacities of human skin in comparison with a 3D-epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: phase II enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Cytochrome P450-mediated activation of the fragrance compound geraniol forms potent contact allergens

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Expression of cholesterol sulfotransferase (SULT2B1b) in human skin and primary cultures of human epidermal keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Intralaboratory and interlaboratory evaluation of the EpiDerm 3D human reconstructed skin micronucleus (RSMN) assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Xenobiotic metabolism gene expression in the EpiDermin vitro 3D human epidermis model compared to human skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Electrochemiluminescent arrays for cytochrome P450-activated genotoxicity screening. DNA damage from benzo[a]pyrene metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Expression profiles of phases 1 and 2 metabolizing enzymes in human skin and the reconstructed skin models Episkin and full thickness model from Episkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: skin irritation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Under the skin: Biotransformation of para-aminophenol and para-phenylenediamine in reconstructed human epidermis and human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Drug-metabolizing enzymes in the skin of man, rat, and pig.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Cutaneous metabolic activation of carvoxime, a self-activating, skin-sensitizing prohapten

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

A comparative study of leukaemia inhibitory factor and interleukin-1alpha intracellular content in a human keratinocyte cell line after exposure to cosmetic fragrances and sodium dodecyl sulphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Genetic factors in contact allergy--review and future goals

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Preferential glutathione conjugation of a reverse diol epoxide compared with a bay region diol epoxide of benzo[a]pyrene in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Elucidation of xenobiotic metabolism pathways in human skin and human skin models by proteomic profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Photophysical properties and photobiological behavior of amodiaquine, primaquine and chloroquine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Prostaglandin H synthases and their importance in chemical toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Effect of PCB153 on BaP-induced genotoxicity in HepG2 cells via modulation of metabolic enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Baculovirus vectors: novel mammalian cell gene-delivery vehicles and their applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

Cyclooxygenase-2 expression during immortalization and breast cancer progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT080

21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFT080

1 reference

9 September 2017

1 reference