Towards quantitative prediction of oral drug absorption (Q37265500)

19 August 2017

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title

Towards quantitative prediction of oral drug absorption (English)

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19 August 2017

Jennifer B Dressman

1

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19 August 2017

Kirstin Thelen

series ordinal

2

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19 August 2017

Ekarat Jantratid

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3

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19 August 2017

1 January 2008

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Clinical Pharmacokinetics

19 August 2017

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19 August 2017

47

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19 August 2017

10

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19 August 2017

655-667

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https://scigraph.springernature.com/pub.10.2165/00003088-200847100-00003

19 August 2017

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cites work

Felodipine kinetics in healthy men.

1 reference

Crossref

https://api.crossref.org/works/10.2165%2F00003088-200847100-00003

Prediction of human pharmacokinetics--gut-wall metabolism

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.2165%2F00003088-200847100-00003

A strategy for preclinical formulation development using GastroPlus as pharmacokinetic simulation tool and a statistical screening design applied to a dog study

21 January 2018

1 reference

12 December 2020

Prediction of oral drug absorption in humans by theoretical passive absorption model

1 reference

12 December 2020

Feasibility of biowaiver extension to biopharmaceutics classification system class III drug products: cimetidine

1 reference

12 December 2020

Gentamicin pharmacokinetics during slow daily home hemodialysis

1 reference

12 December 2020

The human intestinal cytochrome P450 "pie".

1 reference

12 December 2020

Comparison of oral absorption and bioavailablity of drugs between monkey and human

1 reference

12 December 2020

Nifedipine: kinetics and dynamics in healthy subjects

1 reference

12 December 2020

A physiological model for the estimation of the fraction dose absorbed in humans.

1 reference

12 December 2020

Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compounds

1 reference

12 December 2020

Linear correlation of the fraction of oral dose absorbed of 64 drugs between humans and rats

1 reference

12 December 2020

Predicting the impact of physiological and biochemical processes on oral drug bioavailability

1 reference

12 December 2020

High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes

1 reference

12 December 2020

Predicting pharmacokinetic food effects using biorelevant solubility media and physiologically based modelling.

1 reference

12 December 2020

In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man--fact or myth

1 reference

12 December 2020

Characterization of the human upper gastrointestinal contents under conditions simulating bioavailability/bioequivalence studies.

1 reference

12 December 2020

Comparison of HT29-18-C1 and Caco-2 cell lines as models for studying intestinal paracellular drug absorption.

1 reference

12 December 2020

Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach

1 reference

12 December 2020

Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption

1 reference

12 December 2020

Determination of in vivo absorption, metabolism, and transport of drugs by the human intestinal wall and liver with a novel perfusion technique.

1 reference

12 December 2020

Characterization of human small intestinal cytochromes P-450.

1 reference

12 December 2020

In vitro permeability through caco-2 cells is not quantitatively predictive of in vivo absorption for peptide-like drugs absorbed via the dipeptide transporter system

1 reference

12 December 2020

Development and validation of a physiology-based model for the prediction of oral absorption in monkeys

1 reference

12 December 2020

1 reference

12 December 2020

A comparative study of artificial membrane permeability assay for high throughput profiling of drug absorption potential

1 reference

12 December 2020

The pharmacokinetics of midazolam in man.

1 reference

12 December 2020

First-order elimination kinetics following baclofen overdose

1 reference

12 December 2020

Physiologically-based pharmacokinetic simulation modelling.

1 reference

12 December 2020

In vitro-in vivo correlations for lipophilic, poorly water-soluble drugs

1 reference

12 December 2020

Cytochromes P-450 in the intestinal mucosa of man

1 reference

12 December 2020

Mixing-tank model for predicting dissolution rate control or oral absorption

1 reference

12 December 2020

Predicting ADME properties in silico: methods and models

1 reference

12 December 2020

From in vivo to in vitro/in silico ADME: progress and challenges

1 reference

12 December 2020

Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: relationship to absorption in humans

1 reference

12 December 2020

Dissolution Kinetics of Drugs in Human Gastric Juice—The Role of Surface Tension

1 reference

12 December 2020

Prediction of human pharmacokinetics using physiologically based modeling: a retrospective analysis of 26 clinically tested drugs.

1 reference

12 December 2020

First-pass metabolism of midazolam by the human intestine.

1 reference

12 December 2020

Dissolution media simulating conditions in the proximal human gastrointestinal tract: an update.

1 reference

12 December 2020

Effect of simulated intestinal fluid on drug permeability estimation across Caco-2 monolayers.

1 reference

12 December 2020

A dynamic in vitro lipolysis model

1 reference

12 December 2020

Characterization of fluids from the stomach and proximal jejunum in men and women.

1 reference

12 December 2020

Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of poly(ethylene glycol) and D-peptides

1 reference

12 December 2020

Biowaiver monographs for immediate release solid oral dosage forms: isoniazid

1 reference

12 December 2020

Characterization of human cytochrome P450 enzymes

1 reference

12 December 2020

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1 reference

12 December 2020

Prediction of intestinal first-pass drug metabolism

1 reference

12 December 2020

Paracellular glucose transport plays a minor role in the unanesthetized dog.

1 reference

12 December 2020

Development of a 7-day, 96-well Caco-2 permeability assay with high-throughput direct UV compound analysis.

1 reference

12 December 2020

Prediction of intestinal absorption: comparative assessment of GASTROPLUS and IDEA.

1 reference

12 December 2020

PAMPA--critical factors for better predictions of absorption

1 reference

12 December 2020

Intestinal and Hepatic Metabolic Activity of Five Cytochrome P450 Enzymes: Impact on Prediction of First-Pass Metabolism

1 reference

12 December 2020

Clinical Pharmacokinetics of Ranitidine

1 reference

12 December 2020

The nifedipine-rifampin interaction. Evidence for induction of gut wall metabolism

1 reference

12 December 2020

A compartmental absorption and transit model for estimating oral drug absorption.

1 reference

12 December 2020

Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression.

1 reference

12 December 2020

Cyclosporin clinical pharmacokinetics

1 reference

12 December 2020

First-pass metabolism of cyclosporin by the gut

1 reference

12 December 2020

Oral absorption of poorly water-soluble drugs: computer simulation of fraction absorbed in humans from a miniscale dissolution test.

1 reference

12 December 2020

Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism.

1 reference

12 December 2020

Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability

1 reference

12 December 2020

Human intestinal permeability

1 reference

12 December 2020

Ionic constituents and osmolality of gastric and small-intestinal fluids after eating

1 reference

12 December 2020

High throughput prediction of oral absorption: improvement of the composition of the lipid solution used in parallel artificial membrane permeation assay

1 reference

12 December 2020

From physicochemistry to absorption and distribution: predictive mechanistic modelling and computational tools

1 reference

12 December 2020

Development of predictive pharmacokinetic simulation models for drug discovery

1 reference

12 December 2020

Cytochrome P450 3A expression and activity in the human small intestine

1 reference

12 December 2020

Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs.

1 reference

12 December 2020

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism

1 reference

12 December 2020

Is the role of the small intestine in first-pass metabolism overemphasized?

1 reference

12 December 2020

Caco-2 monolayers in experimental and theoretical predictions of drug transport

1 reference

12 December 2020

Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes

1 reference

12 December 2020

Investigation of nifedipine absorption in different regions of the human gastrointestinal (GI) tract after simultaneous administration of 13C- and 12C-nifedipine

1 reference

12 December 2020

Pharmacokinetics of hydrochlorothiazide in man

1 reference

12 December 2020

Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations

1 reference

12 December 2020

A dynamic in vitro lipolysis model. II: Evaluation of the model

1 reference

12 December 2020

Physiology-based pharmacokinetic modeling: ready to be used

1 reference

12 December 2020

Dissolution testing as a prognostic tool for oral drug absorption: immediate release dosage forms

1 reference

12 December 2020

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man

1 reference

12 December 2020

Effects of food on drug absorption

1 reference

12 December 2020

10.2165/00003088-200847100-00003

Identifiers

DOI

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Dimensions Publication ID

19 August 2017

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