In vitro-in vivo extrapolation of hepatic clearance: biological tools, scaling factors, model assumptions and correct concentrations (Q36985051)

17 August 2017

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title

In vitro-in vivo extrapolation of hepatic clearance: biological tools, scaling factors, model assumptions and correct concentrations (English)

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ORCID Public Data File 2021

17 August 2017

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author name string

Pelkonen O

series ordinal

1

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PubMed ID

17968737

17 August 2017

Turpeinen M

series ordinal

2

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PubMed ID

17968737

17 August 2017

language of work or name

English

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publication date

1 October 2007

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17 August 2017

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17 August 2017

37

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17 August 2017

10-11

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17 August 2017

1066-1089

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Cell lines as in vitro models for drug screening and toxicity studies

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Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

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Interlaboratory comparison of the assessment of P450 activities in human hepatic microsomal samples.

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Standard liver volume in the Caucasian population.

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Database analyses for the prediction of in vivo drug-drug interactions from in vitro data

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Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes

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Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

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Changes in liver volume from birth to adulthood: a meta-analysis.

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In vitro tests for predicting drug-drug interactions: the need for validated procedures

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Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation.

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Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line

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Preclinical evaluation of drug-drug interaction potential: present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction.

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Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics

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Nonspecific binding of drugs to human liver microsomes

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Impact of drug transporter studies on drug discovery and development

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10.1080/00498250701620726

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference

PubMed ID

17968737