Development and specification of physiologically based pharmacokinetic models for use in risk assessment (Q37031081)

17 August 2017

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title

Development and specification of physiologically based pharmacokinetic models for use in risk assessment (English)

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17 August 2017

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2

Harvey J Clewell

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17 August 2017

Rebecca A Clewell

1

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PubMed ID

18077066

17 August 2017

language of work or name

English

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publication date

6 November 2007

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Regulatory Toxicology and Pharmacology

17 August 2017

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17 August 2017

50

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17 August 2017

129-143

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17 August 2017

1

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Quantitative Relations in the Physiological Constitutions of Mammals

17 August 2017

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Investigation of the impact of pharmacokinetic variability and uncertainty on risks predicted with a pharmacokinetic model for chloroform

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Physiologically based pharmacokinetic modeling with dichloromethane, its metabolite, carbon monoxide, and blood carboxyhemoglobin in rats and humans.

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Physiologically based pharmacokinetics and the risk assessment process for methylene chloride.

7 January 2021

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Tissue dosimetry, pharmacokinetic modeling, and interspecies scaling factors

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Determination of the kinetic constants for metabolism of inhaled toxicants in vivo using gas uptake measurements

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Physiological parameter values for physiologically based pharmacokinetic models

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Evaluation of the potential impact of age- and gender-specific pharmacokinetic differences on tissue dosimetry

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Comparison of cancer risk estimates for vinyl chloride using animal and human data with a PBPK model.

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Sensitivity of physiologically based pharmacokinetic models to variation in model parameters: methylene chloride.

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Perchlorate and radioiodide kinetics across life stages in the human: using PBPK models to predict dosimetry and thyroid inhibition and sensitive subpopulations based on developmental stage.

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The use of physiologically based models to integrate diverse data sets and reduce uncertainty in the prediction of perchlorate and iodide kinetics across life stages and species

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Physiologically based pharmacokinetics of 2-butoxyethanol and its major metabolite, 2-butoxyacetic acid, in rats and humans

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Development of a physiologically based pharmacokinetic model for chloroform

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The use of Markov chain Monte Carlo uncertainty analysis to support a Public Health Goal for perchloroethylene

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Physiologically based pharmacokinetic modeling with trichloroethylene and its metabolite, trichloroacetic acid, in the rat and mouse

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7 January 2021

Identifiers

DOI

1 reference

17 August 2017

1 reference

PubMed ID

18077066