Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II. (Q43244977)

17 November 2017

Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II. (English)

1 reference

17 November 2017

Shu-Feng Zhou

1

1 reference

17 November 2017

1 January 2009

1 reference

Clinical Pharmacokinetics

17 November 2017

1 reference

17 November 2017

48

1 reference

17 November 2017

761-804

1 reference

17 November 2017

12

1 reference

https://scigraph.springernature.com/pub.10.2165/11318070-000000000-00000

17 November 2017

0 references

cites work

Clomipramine vs desipramine vs placebo in the treatment of diabetic neuropathy symptoms. A double-blind cross-over study.

1 reference

https://api.crossref.org/works/10.2165%2F11318070-000000000-00000

Hydroxylation of desmethylimipramine: dependence on the debrisoquin hydroxylation phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318070-000000000-00000

Maprotiline metabolism appears to co-segregate with the genetically-determined CYP2D6 polymorphic hydroxylation of debrisoquine

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318070-000000000-00000

The role of cytochrome P4502D6 in the metabolism of paroxetine by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318070-000000000-00000

The potential therapeutic role of the enantiomers and metabolites of mianserin

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318070-000000000-00000

Variability in the elimination of mianserin in elderly patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318070-000000000-00000

A Review of the Pharmacological and Clinical Profile of Mirtazapine

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318070-000000000-00000

Genetically determined drug-metabolizing activity and desipramine-associated cardiotoxicity: a case report

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318070-000000000-00000

The effect of enzyme inhibition on the metabolism and activation of tacrine by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318070-000000000-00000

Single-dose and steady-state pharmacokinetics of tomoxetine in normal subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318070-000000000-00000

The pharmacokinetics of ondansetron after intravenous injection in healthy volunteers phenotyped as poor or extensive metabolisers of debrisoquine

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318070-000000000-00000

Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318070-000000000-00000

Oxidative metabolism of flunarizine and cinnarizine by microsomes from B-lymphoblastoid cell lines expressing human cytochrome P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318070-000000000-00000

Drug-induced extrapyramidal reactions. Treatment with diphenhydramine hydrochloride and dihydroxyphenylalanine.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318070-000000000-00000

Pharmacokinetics of diphenhydramine and a demethylated metabolite following intravenous and oral administration.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318070-000000000-00000

CYP2D6 phenotype determines the metabolic conversion of hydrocodone to hydromorphone.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318070-000000000-00000

Single-dose and steady-state pharmacokinetics and pharmacodynamics of oxycodone in patients with cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318070-000000000-00000

Inhibition by fluoxetine of cytochrome P450 2D6 activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318070-000000000-00000

Inhibition of human cytochrome P450 2D6 (CYP2D6) by methadone

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318070-000000000-00000

Impact of CYP2D6 genetic polymorphism on tramadol pharmacokinetics and pharmacodynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318070-000000000-00000

Genetic polymorphism of phenformin 4-hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318070-000000000-00000

Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318070-000000000-00000

Role of cytochrome P450 2D6 (CYP2D6) in the stereospecific metabolism of E- and Z-doxepin

21 January 2018

1 reference

12 December 2020

The mu1, mu2, delta, kappa opioid receptor binding profiles of methadone stereoisomers and morphine

1 reference

12 December 2020

Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients

1 reference

12 December 2020

Relationship between plasma desipramine levels, CYP2D6 phenotype and clinical response to desipramine: a prospective study

1 reference

12 December 2020

Population pharmacokinetic analysis of mirtazapine

1 reference

12 December 2020

The effects of tramadol on static and dynamic pupillometry in healthy subjects--the relationship between pharmacodynamics, pharmacokinetics and CYP2D6 metaboliser status

1 reference

12 December 2020

Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism

1 reference

12 December 2020

Disposition and metabolic fate of atomoxetine hydrochloride: the role of CYP2D6 in human disposition and metabolism

1 reference

12 December 2020

Identification of diphenydramine (Benadryl) metabolities in human subjects.

1 reference

12 December 2020

Classic histamine H1 receptor antagonists: a critical review of their metabolic and pharmacokinetic fate from a bird's eye view

1 reference

12 December 2020

Involvement of human cytochrome P450 3A4 in reduced haloperidol oxidation

1 reference

12 December 2020

Effects of the CYP2D6*10 allele on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese patients with schizophrenia

1 reference

12 December 2020

Contributions of CYP2D6, CYP2C9 and CYP2C19 to the biotransformation of E- and Z-doxepin in healthy volunteers

1 reference

12 December 2020

CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status.

1 reference

12 December 2020

Donepezil use in Alzheimer disease

1 reference

12 December 2020

CYP2D6*10 alleles are not the determinant of the plasma haloperidol concentrations in Asian patients

1 reference

12 December 2020

Doxepin up-to-date: a review of its pharmacological properties and therapeutic efficacy with particular reference to depression

1 reference

12 December 2020

Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding

1 reference

12 December 2020

CYP2D6 genotype: impact on adverse effects and nonresponse during treatment with antidepressants-a pilot study.

1 reference

12 December 2020

Disposition of loratadine in healthy volunteers

1 reference

12 December 2020

Identification of the human cytochromes P450 responsible for the in vitro formation of the major oxidative metabolites of the antipsychotic agent olanzapine.

1 reference

12 December 2020

Semi-quantitative CYP2D6 gene doses in relation to metabolic ratios of psychotropics

1 reference

12 December 2020

Discovery of a novel nonfunctional cytochrome P450 2D6 allele, CYP2D642, in African American subjects

1 reference

12 December 2020

Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6.

1 reference

12 December 2020

A fatal doxepin poisoning associated with a defective CYP2D6 genotype.

1 reference

12 December 2020

Polymorphisms in the 5-hydroxytryptamine 2A receptor and CytochromeP4502D6 genes synergistically predict fluvoxamine-induced side effects in japanese depressed patients.

1 reference

12 December 2020

CYP2D6 metabolizer status and atomoxetine dosing in children and adolescents with ADHD.

1 reference

12 December 2020

Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment

1 reference

12 December 2020

The CYP2D6 polymorphism in relation to the metabolism of amitriptyline and nortriptyline in the Faroese population

1 reference

12 December 2020

Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine

1 reference

12 December 2020

Allele-specific change of concentration and functional gene dose for the prediction of steady-state serum concentrations of amitriptyline and nortriptyline in CYP2C19 and CYP2D6 extensive and intermediate metabolizers

1 reference

12 December 2020

Slow hydroxylation of nortriptyline and concomitant poor debrisoquine hydroxylation: clinical implications

1 reference

12 December 2020

Safety profile of atomoxetine in the treatment of children and adolescents with ADHD.

1 reference

12 December 2020

Nortriptyline intoxication induced by terbinafine.

1 reference

12 December 2020

The stereoselective metabolism of fluoxetine in poor and extensive metabolizers of sparteine

1 reference

12 December 2020

Effect of the CYP2D6 genotype on the pharmacokinetics of tropisetron in healthy Korean subjects.

1 reference

12 December 2020

Evidence for involvement of polymorphic CYP2C19 and 2C9 in the N-demethylation of sertraline in human liver microsomes

1 reference

12 December 2020

Identification of human cytochrome p450 isozymes involved in diphenhydramine N-demethylation.

1 reference

12 December 2020

Two novel haplotypes of CYP2D6 gene in a Japanese population

1 reference

12 December 2020

Tamoxifen pharmacogenomics: the role of CYP2D6 as a predictor of drug response

1 reference

12 December 2020

Influence of quinidine on the pharmacokinetics of trimipramine and on its effect on the waking EEG of healthy volunteers. A pilot study on two subjects.

1 reference

12 December 2020

Dihydrocodeine: a new opioid substrate for the polymorphic CYP2D6 in humans

1 reference

12 December 2020

Pharmacogenetics-guided dose modifications of antidepressants

1 reference

12 December 2020

CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes.

1 reference

12 December 2020

Tolterodine does not affect the human in vivo metabolism of the probe drugs caffeine, debrisoquine and omeprazole

1 reference

12 December 2020

Ondansetron. Therapeutic use as an antiemetic

1 reference

12 December 2020

Inhibition of cytochrome P450 2D6 metabolism of hydrocodone to hydromorphone does not importantly affect abuse liability.

1 reference

12 December 2020

Cytochrome P450-catalyzed metabolism of ezlopitant alkene (CJ-12,458), a pharmacologically active metabolite of ezlopitant: enzyme kinetics and mechanism of an alkene hydration reaction

1 reference

12 December 2020

A review of the association between antipsychotic use and hyperprolactinaemia

1 reference

12 December 2020

Impact of the CYP2D6 polymorphism on steady-state plasma concentrations and clinical outcome of donepezil in Alzheimer's disease patients.

1 reference

12 December 2020

Metabolism of epinastine, a histamine H1 receptor antagonist, in human liver microsomes in comparison with that of terfenadine

1 reference

12 December 2020

Increased incidence of CYP2D6 gene duplication in patients with persistent mood disorders: ultrarapid metabolism of antidepressants as a cause of nonresponse. A pilot study

1 reference

12 December 2020

O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants

1 reference

12 December 2020

Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes

1 reference

12 December 2020

Paroxetine. An update of its pharmacology and therapeutic use in depression and a review of its use in other disorders

1 reference

12 December 2020

Atypical antipsychotic agents: a critical review

1 reference

12 December 2020

Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6, and CYP1A2: A panel study*

1 reference

12 December 2020

Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review

1 reference

12 December 2020

Effects of smoking, CYP2D6 genotype, and concomitant drug intake on the steady state plasma concentrations of haloperidol and reduced haloperidol in schizophrenic inpatients.

1 reference

12 December 2020

Lack of effect of mianserin on the symptoms of diabetic neuropathy

1 reference

12 December 2020

5-HT(3)-receptor antagonists in the management of nausea and vomiting in cancer and cancer treatment

1 reference

12 December 2020

Influence of CYP2C9, 2C19 and 2D6 genetic polymorphisms on the steady-state plasma concentrations of the enantiomers of fluoxetine and norfluoxetine.

1 reference

12 December 2020

Tropisetron. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential as an antiemetic

1 reference

12 December 2020

Upcoming agents for the treatment of schizophrenia: mechanism of action, efficacy and tolerability

1 reference

12 December 2020

Low daily 10-mg and 20-mg doses of fluvoxamine inhibit the metabolism of both caffeine (cytochrome P4501A2) and omeprazole (cytochrome P4502C19).

1 reference

12 December 2020

Can tamoxifen therapy be optimized for patients with breast cancer on the basis of CYP2D6 activity assessments?

1 reference

12 December 2020

Clinical pharmacokinetics of fluvoxamine

1 reference

12 December 2020

Effects of Polymorphisms in CYP2D6, CYP2C9, and CYP2C19 on Trimipramine Pharmacokinetics

1 reference

12 December 2020

Venlafaxine: a heterocyclic antidepressant.

1 reference

12 December 2020

Nonlinear mixed effects model analysis of the pharmacokinetics of aripiprazole in healthy Japanese males.

1 reference

12 December 2020

Metabolism of citalopram enantiomers in CYP2C19/CYP2D6 phenotyped panels of healthy Swedes

1 reference

12 December 2020

Pharmacokinetics of methadone and its primary metabolite in 20 opiate addicts.

1 reference

12 December 2020

Association between CYP2D6 *10 genotype and survival of breast cancer patients receiving tamoxifen treatment.

1 reference

12 December 2020

Chemotherapy-induced nausea and vomiting: which antiemetic for which therapy?

1 reference

12 December 2020

Impact of polymorphisms of cytochrome-P450 isoenzymes 2C9, 2C19 and 2D6 on plasma concentrations and clinical effects of antidepressants in a naturalistic clinical setting

1 reference

12 December 2020

The impact of the CYP2D6 polymorphism on haloperidol pharmacokinetics and on the outcome of haloperidol treatment.

1 reference

12 December 2020

Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes

1 reference

12 December 2020

Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYPs

1 reference

12 December 2020

Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients

1 reference

12 December 2020

Role of CYP2D6 in the stereoselective disposition of venlafaxine in humans

1 reference

12 December 2020

Stereoselective disposition of mianserin is related to debrisoquin hydroxylation polymorphism

1 reference

12 December 2020

Fluvoxamine and fluoxetine do not interact in the same way with the metabolism of the enantiomers of methadone.

1 reference

12 December 2020

10-Hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes

1 reference

12 December 2020

(R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes

1 reference

12 December 2020

Extension of a pilot study: impact from the cytochrome P450 2D6 polymorphism on outcome and costs associated with severe mental illness.

1 reference

12 December 2020

Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers

1 reference

12 December 2020

Effect of rifampin on the plasma concentration and the clinical effect of haloperidol concomitantly administered to schizophrenic patients

1 reference

12 December 2020

Ketoconazole inhibits the metabolism of tolterodine in subjects with deficient CYP2D6 activity

1 reference

12 December 2020

Clinical pharmacokinetics of mirtazapine

1 reference

12 December 2020

Relative contribution of CYP3A to amitriptyline clearance in humans: in vitro and in vivo studies

1 reference

12 December 2020

The effect of fluoxetine on the pharmacokinetics and safety of risperidone in psychotic patients

1 reference

12 December 2020

Selective estrogen-receptor modulators -- mechanisms of action and application to clinical practice.

1 reference

12 December 2020

Clinically relevant pharmacology of selective serotonin reuptake inhibitors. An overview with emphasis on pharmacokinetics and effects on oxidative drug metabolism

1 reference

12 December 2020

Tertiary N-glucuronides of clozapine and its metabolite desmethylclozapine in patient urine.

1 reference

12 December 2020

CYP2D6 polymorphism in relation to tramadol metabolism: a study of faroese patients

1 reference

12 December 2020

Fluvoxamine. A review of global drug-drug interaction data

1 reference

12 December 2020

The metabolism and excretion of galantamine in rats, dogs, and humans

1 reference

12 December 2020

The disposition of fluoxetine but not sertraline is altered in poor metabolizers of debrisoquin

1 reference

12 December 2020

Effects of blocking CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone.

1 reference

12 December 2020

Pharmacokinetic-pharmacodynamic relationships of oral hypoglycaemic agents. An update

1 reference

12 December 2020

Zuclopenthixol dihydrochloride for schizophrenia

1 reference

12 December 2020

CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants: a first step towards subpopulation-specific dosages

1 reference

12 December 2020

Fluvoxamine. An updated review of its use in the management of adults with anxiety disorders

1 reference

12 December 2020

Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology.

1 reference

12 December 2020

CYP2D6 and clinical response to atomoxetine in children and adolescents with ADHD.

1 reference

12 December 2020

E- and Z-10-hydroxylation of nortriptyline: relationship to polymorphic debrisoquine hydroxylation

1 reference

12 December 2020

Pharmacokinetic genes do not influence response or tolerance to citalopram in the STAR*D sample

1 reference

12 December 2020

Crystal structure of human cytochrome P450 2D6

1 reference

12 December 2020

Plasma levels of the enantiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dextromethorphan and mephenytoin.

1 reference

12 December 2020

Prevention of postoperative nausea and vomiting with granisetron and dolasetron in relation to CYP2D6 genotype.

1 reference

12 December 2020

Metabolism of chlorpheniramine maleate in man

1 reference

12 December 2020

CYP2D6 poor metabolizer status can be ruled out by a single genotyping assay for the -1584G promoter polymorphism.

1 reference

12 December 2020

Therapeutic use of nicergoline

1 reference

12 December 2020

Studies on the Stereoselective Metabolism of Citalopram by Human Liver Microsomes and cDNA-Expressed Cytochrome P450 Enzymes

1 reference

12 December 2020

Safety of aripiprazole: high serum levels in a CYP2D6 mutated patient

1 reference

12 December 2020

Risperidone: a review of its use in the treatment of bipolar mania

1 reference

12 December 2020

The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen

1 reference

12 December 2020

Use of the Mesoridazine/Thioridazine Ratio as a Marker for CYP2D6 Enzyme Activity

1 reference

12 December 2020

The impact of pharmacogenomics on postoperative nausea and vomiting: do CYP2D6 allele copy number and polymorphisms affect the success or failure of ondansetron prophylaxis?

1 reference

12 December 2020

Metabolism of the newer antidepressants. An overview of the pharmacological and pharmacokinetic implications

1 reference

12 December 2020

Disposition of desloratadine in healthy volunteers

1 reference

12 December 2020

CYP2D6 inhibition by selective serotonin reuptake inhibitors: analysis of achievable steady-state plasma concentrations and the effect of ultrarapid metabolism at CYP2D6.

1 reference

12 December 2020

Pharmacogenetics of antidepressant medication intolerance

1 reference

12 December 2020

Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes

1 reference

12 December 2020

The metabolic fate of amitriptyline, nortriptyline and amitriptylinoxide in man.

1 reference

12 December 2020

CYP2D6 phenotype prediction from genotype: which system is the best?

1 reference

12 December 2020

Effect of ketoconazole on venlafaxine plasma concentrations in extensive and poor metabolisers of debrisoquine

1 reference

12 December 2020

Effects of thioridazine, an inhibitor of CYP2D6, on the steady-state plasma concentrations of the enantiomers of mianserin and its active metabolite, desmethylmianserin, in depressed Japanese patients

1 reference

12 December 2020

Paroxetine increases steady-state concentrations of (R)-methadone in CYP2D6 extensive but not poor metabolizers

1 reference

12 December 2020

Disposition of the neuroleptics perphenazine, zuclopenthixol, and haloperidol cosegregates with polymorphic debrisoquine hydroxylation.

1 reference

12 December 2020

Aripiprazole: a review of its use in schizophrenia and schizoaffective disorder

1 reference

12 December 2020

Active-site topologies of human CYP2D6 and its aspartate-301 --> glutamate, asparagine, and glycine mutants.

1 reference

12 December 2020

Demethylation and hydroxylation of amitriptyline, nortriptyline, and 10-hydroxyamitriptyline in human liver microsomes

1 reference

12 December 2020

Pharmacogenetics, drug-metabolizing enzymes, and clinical practice

1 reference

12 December 2020

Metabolism of trimipramine in vitro by human CYP2D6 isozyme

1 reference

12 December 2020

Different effects of inhibitors on the O- and N-demethylation of codeine in human liver microsomes

1 reference

12 December 2020

Cytochrome P450 2D6 genotype does not predict SSRI (fluoxetine or paroxetine) induced hyponatraemia

1 reference

12 December 2020

The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6.

1 reference

12 December 2020

Contribution of UDP-glucuronosyltransferase 1A1 and 1A8 to morphine-6-glucuronidation and its kinetic properties

1 reference

12 December 2020

CYP2D6 genotype in relation to perphenazine concentration and pituitary pharmacodynamic tissue sensitivity in Asians: CYP2D6-serotonin-dopamine crosstalk revisited.

1 reference

12 December 2020

Variation in the CYP2D6 gene is associated with a lower serum sodium concentration in patients on antidepressants

1 reference

12 December 2020

Debrisoquine hydroxylation phenotypes of patients with high versus low to normal serum antidepressant concentrations

1 reference

12 December 2020

Selective estrogen-receptor modulators and antihormonal resistance in breast cancer

1 reference

12 December 2020

Risperidone: a review

1 reference

12 December 2020

Olanzapine disposition in humans is unrelated to CYP1A2 and CYP2D6 phenotypes

1 reference

12 December 2020

Clinical pharmacology of tramadol

1 reference

12 December 2020

The genetic control of phenformin 4-hydroxylation

1 reference

12 December 2020

Atypical antipsychotic drugs: current issues of safety and efficacy in the management of schizophrenia.

1 reference

12 December 2020

Fluvoxamine and fluoxetine: interaction studies with amitriptyline, clomipramine and neuroleptics in phenotyped patients

1 reference

12 December 2020

Methadone: a review of its pharmacokinetic/pharmacodynamic properties.

1 reference

12 December 2020

Human metabolism of dolasetron mesylate, a 5-HT3 receptor antagonist

1 reference

12 December 2020

Clomipramine: an antiobsessional tricyclic antidepressant

1 reference

12 December 2020

Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17

1 reference

12 December 2020

Influence of CYP2D6 activity on the disposition and cardiovascular toxicity of the antidepressant agent venlafaxine in humans

1 reference

12 December 2020

Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer

1 reference

12 December 2020

Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine

1 reference

12 December 2020

Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins.

1 reference

12 December 2020

Cytochrome P450 enzymes contributing to demethylation of maprotiline in man.

1 reference

12 December 2020

Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen.

1 reference

12 December 2020

Enhancement of atomoxetine serum levels by co-administration of paroxetine.

1 reference

12 December 2020

Antipsychotic-induced hyperprolactinaemia, hypogonadism and osteoporosis in the treatment of schizophrenia

1 reference

12 December 2020

Pharmacokinetics of tramadol enantiomers and their respective phase I metabolites in relation to CYP2D6 phenotype

1 reference

12 December 2020

Clozapine-induced agranulocytosis and hereditary polymorphisms of clozapine metabolizing enzymes: no association with myeloperoxidase and cytochrome P4502D6

1 reference

12 December 2020

Influence of Cyp2D6 Genetic Polymorphism on Ratios of Steady-state Serum Concentration to Dose of the Neuroleptic Zuclopenthixol

1 reference

12 December 2020

5-HT3 receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting. A comparison of their pharmacology and clinical efficacy

1 reference

12 December 2020

Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives

1 reference

12 December 2020

Hydroxylation of debrisoquine in patients with lacticacidosis after phenformin

1 reference

12 December 2020

Antipsychotics and hyperprolactinaemia: clinical recommendations

1 reference

12 December 2020

Pharmacology, toxicology and human pharmacokinetics of tropisetron

1 reference

12 December 2020

Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study

1 reference

12 December 2020

Imipramine demethylation and hydroxylation: impact of the sparteine oxidation phenotype

1 reference

12 December 2020

Pharmacogenetic determination of the effects of codeine and prediction of drug interactions

1 reference

12 December 2020

CYP2D6 polymorphisms and the risk of tardive dyskinesia in schizophrenia: a meta-analysis.

1 reference

12 December 2020

Relevance of deficient CYP2D6 in opiate dependence

1 reference

12 December 2020

Steady-state plasma levels of E- and Z-10-OH-nortriptyline in nortriptyline-treated patients: significance of concurrent medication and the sparteine oxidation phenotype.

1 reference

12 December 2020

CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxine

1 reference

12 December 2020

Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation (cytochrome P-450 dbl/bufI)

1 reference

12 December 2020

Paroxetine potentiates the central nervous system side effects of perphenazine: contribution of cytochrome P4502D6 inhibition in vivo.

1 reference

12 December 2020

Polymorphisms in the CYP 2D6 gene: association with plasma concentrations of fluoxetine and paroxetine

1 reference

12 December 2020

The role of novel antipsychotics in bipolar disorders.

1 reference

12 December 2020

Chemoprevention of breast cancer with selective oestrogen-receptor modulators

1 reference

12 December 2020

Clinical pharmacokinetics of fluvoxamine: applications to dosage regimen design

1 reference

12 December 2020

Fatality caused by a combined trimipramine-citalopram intoxication

1 reference

12 December 2020

Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype

1 reference

12 December 2020

Identification of the human cytochromes p450 responsible for in vitro formation of R- and S-norfluoxetine.

1 reference

12 December 2020

The CYP2D6 genotype and plasma concentrations of mianserin enantiomers in relation to therapeutic response to mianserin in depressed Japanese patients

1 reference

12 December 2020

Metabolism of the antidepressant mirtazapine in vitro: contribution of cytochromes P-450 1A2, 2D6, and 3A4

1 reference

12 December 2020

Inhibition of antidepressant demethylation and hydroxylation by fluvoxamine in depressed patients

1 reference

12 December 2020

In vitro identification of the human cytochrome P-450 enzymes involved in the N-demethylation of azelastine.

1 reference

12 December 2020

Pharmacokinetics of haloperidol: an update

1 reference

12 December 2020

Identification of the cytochrome P450 IIIA family as the enzymes involved in the N-demethylation of tamoxifen in human liver microsomes

1 reference

12 December 2020

Tolterodine: an overview

1 reference

12 December 2020

Concordance between tramadol and dextromethorphan parent/metabolite ratios: the influence of CYP2D6 and non-CYP2D6 pathways on biotransformation

1 reference

12 December 2020

Impact of CYP2D6*10 on recurrence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy.

1 reference

12 December 2020

Single dose dihydrocodeine for acute postoperative pain

1 reference

12 December 2020

Pharmacokinetics of selective serotonin reuptake inhibitors

1 reference

12 December 2020

D2 dopamine receptor occupancy during low-dose treatment with haloperidol decanoate

1 reference

12 December 2020

Serum Concentrations and Side Effects in Psychiatric Patients During Risperidone Therapy

1 reference

12 December 2020

Impact of CYP2D6*10 on H1-antihistamine-induced hypersomnia.

1 reference

12 December 2020

Characterization of the human cytochrome P450 enzymes involved in the metabolism of dihydrocodeine

1 reference

12 December 2020

A review of the pharmacological and clinical profile of mirtazapine

1 reference

12 December 2020

Pharmacogenetics of classical and new antipsychotic drugs

1 reference

12 December 2020

Cytochrome P450 3A inhibitor itraconazole affects plasma concentrations of risperidone and 9-hydroxyrisperidone in schizophrenic patients.

1 reference

12 December 2020

Substrate specificity, inhibitors and regulation of human cytochrome P450 2D6 and implications in drug development

1 reference

12 December 2020

Patient-tailored antiemetic treatment with 5-hydroxytryptamine type 3 receptor antagonists according to cytochrome P-450 2D6 genotypes

1 reference

12 December 2020

Inhibitory effects of H1-antihistamines on CYP2D6- and CYP2C9-mediated drug metabolic reactions in human liver microsomes

1 reference

12 December 2020

Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans

1 reference

12 December 2020

The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19.

1 reference

12 December 2020

Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection

1 reference

12 December 2020

The clinical pharmacokinetics of escitalopram

1 reference

12 December 2020

CYP2D6 catalyzes tamoxifen 4-hydroxylation in human liver

1 reference

12 December 2020

Genetically deficient CYP2D6 metabolism provides protection against oral opiate dependence.

1 reference

12 December 2020

5-hydroxytryptamine type-3 receptor antagonists for chemotherapy-induced and radiotherapy-induced nausea and emesis: can we safely reduce the dose of administered agents?

1 reference

12 December 2020

Steady-state plasma levels of nortriptyline and its 10-hydroxy metabolite: relationship to the CYP2D6 genotype.

1 reference

12 December 2020

Risperidone. A review of its pharmacology and therapeutic potential in the treatment of schizophrenia

1 reference

12 December 2020

Adverse drug reactions to oxycodone and hydrocodone in CYP2D6 ultrarapid metabolizers

1 reference

12 December 2020

Extremely rapid hydroxylation of debrisoquine: a case report with implication for treatment with nortriptyline and other tricyclic antidepressants.

1 reference

12 December 2020

The CYP2D6 genotype predicts the oral clearance of the neuroleptic agents perphenazine and zuclopenthixol.

1 reference

12 December 2020

Next generation antihistamines: therapeutic rationale, accomplishments and advances

1 reference

12 December 2020

Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings

1 reference

12 December 2020

ABCB1 and cytochrome P450 genotypes and phenotypes: Influence on methadone plasma levels and response to treatment

1 reference

12 December 2020

Maintenance therapy with zuclopenthixol decanoate: associations between plasma concentrations, neurological side effects and CYP2D6 genotype

1 reference

12 December 2020

Impact of CYP1A2 and CYP2D6 polymorphisms on drug metabolism and on insulin and lipid elevations and insulin resistance in clozapine-treated patients

1 reference

12 December 2020

1 reference

12 December 2020

The relationship between serum concentration and therapeutic effect of haloperidol in patients with acute schizophrenia

1 reference

12 December 2020

The polymorphic cytochrome P-4502D6 is involved in the metabolism of both 5-hydroxytryptamine antagonists, tropisetron and ondansetron

1 reference

12 December 2020

Paroxetine Steady-State Plasma Concentration in Relation to CYP2D6 Genotype in Extensive Metabolizers

1 reference

12 December 2020

Pharmacokinetics of Mirtazapine: Enantioselective Effects of the CYP2D6 Ultra Rapid Metabolizer Genotype and Correlation with Adverse Effects

1 reference

12 December 2020

In vitro characterization of cytochrome P450 catalysed metabolism of the antiemetic tropisetron

1 reference

12 December 2020

Therapeutic drug monitoring of racemic citalopram: a 5-year experience in Sweden, 1992-1997.

1 reference

12 December 2020

Pharmacokinetic variability of aripiprazole and the active metabolite dehydroaripiprazole in psychiatric patients.

1 reference

12 December 2020

Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine. Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6.

1 reference

12 December 2020

Prospective cytochrome P450 phenotyping for neuroleptic treatment in dementia.

1 reference

12 December 2020

Effect of cyp2d6*10 allele on the pharmacokinetics of loratadine in chinese subjects

1 reference

12 December 2020

Influence of comedication on serum concentrations of aripiprazole and dehydroaripiprazole

1 reference

12 December 2020

Haloperidol plasma concentration in Japanese psychiatric subjects with gene duplication of CYP2D6.

1 reference

12 December 2020

Enantioselective pharmacokinetics of tramadol in CYP2D6 extensive and poor metabolizers

1 reference

12 December 2020

Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes

1 reference

12 December 2020

Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine

1 reference

12 December 2020

The African-specific CYP2D617 allele encodes an enzyme with changed substrate specificity

1 reference

12 December 2020

Tramadol as a new probe for cytochrome P450 2D6 phenotyping: a population study

1 reference

12 December 2020

Variability of diphenhydramine N-glucuronidation in healthy subjects.

1 reference

12 December 2020

Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes

1 reference

12 December 2020

Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother

1 reference

12 December 2020

Impact of multiple inhibitors or substrates of cytochrome P450 2D6 on plasma risperidone levels in patients on polypharmacy

1 reference

12 December 2020

Serum concentrations of venlafaxine and its metabolites O-desmethylvenlafaxine and N-desmethylvenlafaxine in heterozygous carriers of the CYP2D6*3, *4 or *5 allele.

1 reference

12 December 2020

Genetic impairment of phenformin metabolism

1 reference

12 December 2020

Risperidone metabolism and the impact of being a cytochrome P450 2D6 ultrarapid metabolizer

1 reference

12 December 2020

Metabolism of ezlopitant, a nonpeptidic substance P receptor antagonist, in liver microsomes: enzyme kinetics, cytochrome P450 isoform identity, and in vitro-in vivo correlation.

1 reference

12 December 2020

A discordance between cytochrome P450 2D6 genotype and phenotype in patients undergoing methadone maintenance treatment

1 reference

12 December 2020

Mu receptor binding of some commonly used opioids and their metabolites

1 reference

12 December 2020

No evidence of increased adverse drug reactions in cytochrome P450 CYP2D6 poor metabolizers treated with fluoxetine or nortriptyline

1 reference

12 December 2020

Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism.

1 reference

12 December 2020

Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer

1 reference

12 December 2020

Relationship between CYP 2D6 metabolic status and sexual dysfunction in paroxetine treatment

1 reference

12 December 2020

The biotransformation of clomipramine in vitro, identification of the cytochrome P450s responsible for the separate metabolic pathways

1 reference

12 December 2020

Effect of the CYP2D6*10 C188T polymorphism on postoperative tramadol analgesia in a Chinese population.

1 reference

12 December 2020

Involvement of CYP2D6 but not CYP2C19 in nicergoline metabolism in humans

1 reference

12 December 2020

Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant

1 reference

12 December 2020

CYP3A is responsible for N-dealkylation of haloperidol and bromperidol and oxidation of their reduced forms by human liver microsomes

1 reference

12 December 2020

Pharmacokinetics of aripiprazole, a new antipsychotic, following oral dosing in healthy adult Japanese volunteers: influence of CYP2D6 polymorphism.

1 reference

12 December 2020

Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity

1 reference

12 December 2020

Atomoxetine pharmacokinetics in healthy Chinese subjects and effect of the CYP2D6*10 allele

1 reference

12 December 2020

Identification of human cytochrome P450 isoforms involved in the 7-hydroxylation of chlorpromazine by human liver microsomes

1 reference

12 December 2020

Simultaneous high-performance liquid chromatography-electrochemical detection determination of imipramine, desipramine, their 2-hydroxylated metabolites, and imipramine N-oxide in human plasma and urine: preliminary application to oxidation pharmaco

1 reference

12 December 2020

Steady-state plasma levels of nortriptyline and its hydroxylated metabolites in Japanese patients: impact of CYP2D6 genotype on the hydroxylation of nortriptyline

1 reference

12 December 2020

Pharmacokinetics of galanthamine (a long-acting anticholinesterase drug) in anaesthetized patients

1 reference

12 December 2020

Cytochrome P450 2D6 genotype and steady state plasma levels of risperidone and 9-hydroxyrisperidone

1 reference

12 December 2020

Plasma concentrations of haloperidol are related to CYP2D6 genotype at low, but not high doses of haloperidol in Korean schizophrenic patients

1 reference

12 December 2020

Chemotherapy-Induced Nausea and Vomiting

1 reference

12 December 2020

CYP2D6 genotype and venlafaxine-XR concentrations in depressed elderly

1 reference

12 December 2020

Analysis of phase I and phase II metabolites of tamoxifen in breast cancer patients

1 reference

12 December 2020

Lack of influence of CYP2D6 genotype on the clearance of (R)-, (S)- and racemic-methadone

1 reference

12 December 2020

Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)- and (S)-methadone in vitro

1 reference

12 December 2020

The visceral and somatic antinociceptive effects of dihydrocodeine and its metabolite, dihydromorphine. A cross-over study with extensive and quinidine-induced poor metabolizers

1 reference

12 December 2020

The convergence of conventional therapeutic drug monitoring and pharmacogenetic testing in personalized medicine: focus on antidepressants

1 reference

12 December 2020

Identification of human liver cytochrome P450s involved in the microsomal metabolism of the antihistaminic drug loratadine

1 reference

12 December 2020

Risperidone metabolism in relation to CYP2D6*10 allele in Korean schizophrenic patients

1 reference

12 December 2020

Chlorpromazine metabolism in extracts of liver and small intestine from guinea pig and from man

1 reference

12 December 2020

Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea

1 reference

12 December 2020

Absorption, metabolism, and excretion of risperidone in humans.

1 reference

12 December 2020

1 reference

12 December 2020

Plasma concentrations of risperidone and 9-hydroxyrisperidone: effect of comedication with carbamazepine or valproate

1 reference

12 December 2020

Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver

1 reference

12 December 2020

CYP2D6 and DRD2 genes differentially impact pharmacodynamic sensitivity and time course of prolactin response to perphenazine.

1 reference

12 December 2020

The roles of CYP2D6 and stereoselectivity in the clinical pharmacokinetics of chlorpheniramine

1 reference

12 December 2020

CYP2D6 is the principal cytochrome P450 responsible for metabolism of the histamine H1 antagonist promethazine in human liver microsomes

1 reference

12 December 2020

Impact of CYP2D6 genotype on postoperative tramadol analgesia

1 reference

12 December 2020

Interaction between fluoxetine and haloperidol: pharmacokinetic and clinical implications

1 reference

12 December 2020

Comparative tolerability profiles of oral antidiabetic agents

1 reference

12 December 2020

Polymorphism in the CYP2D6 Tamoxifen-Metabolizing Gene Influences Clinical Effect but Not Hot Flashes: Data From the Italian Tamoxifen Trial

1 reference

12 December 2020

CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment

1 reference

12 December 2020

Azelastine N-demethylation by cytochrome P-450 (CYP)3A4, CYP2D6, and CYP1A2 in human liver microsomes: evaluation of approach to predict the contribution of multiple CYPs

1 reference

12 December 2020

Maprotiline: a review of its pharmacological properties and therapeutic efficacy in mental depressive states

1 reference

12 December 2020

The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype.

1 reference

12 December 2020

The hypoalgesic effect of tramadol in relation to CYP2D6*

1 reference

12 December 2020

Tolterodine, a new muscarinic receptor antagonist, is metabolized by cytochromes P450 2D6 and 3A in human liver microsomes

1 reference

12 December 2020

Biphasic kinetics of quaternary ammonium glucuronide formation from amitriptyline and diphenhydramine in human liver microsomes.

1 reference

12 December 2020

Impact of the CYP2D6 ultrarapid metabolizer genotype on mirtazapine pharmacokinetics and adverse events in healthy volunteers

1 reference

12 December 2020

Interaction of terfenadine and its primary metabolites with cytochrome P450 2D6

1 reference

12 December 2020

Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6.

1 reference

12 December 2020

Diphenhydramine alters the disposition of venlafaxine through inhibition of CYP2D6 activity in humans

1 reference

12 December 2020

Tricyclic antidepressants (first of two parts).

1 reference

12 December 2020

The effect of fluconazole on the clinical pharmacokinetics of methadone

1 reference

12 December 2020

Different enantioselective 9-hydroxylation of risperidone by the two human CYP2D6 and CYP3A4 enzymes.

1 reference

12 December 2020

Characterization of human cytochrome p450 enzymes involved in the metabolism of the piperidine-type phenothiazine neuroleptic thioridazine

1 reference

12 December 2020

Amitriptyline metabolism: association with debrisoquin hydroxylation in nonsmokers

1 reference

12 December 2020

Depot haloperidol treatment in outpatients with schizophrenia on monotherapy: impact of CYP2D6 polymorphism on pharmacokinetics and treatment outcome

1 reference

12 December 2020

Identification of human p450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its inhibitory effect on enzyme activity

1 reference

12 December 2020

Metabolism of desipramine in Japanese psychiatric patients: the impact of CYP2D6 genotype on the hydroxylation of desipramine

1 reference

12 December 2020

Nonlinear kinetics of imipramine in low and medium plasma level ranges.

1 reference

12 December 2020

Latino versus Caucasian response to atomoxetine in attention-deficit/hyperactivity disorder

1 reference

12 December 2020

Role of the smoking-induced cytochrome P450 (CYP)1A2 and polymorphic CYP2D6 in steady-state concentration of olanzapine

1 reference

12 December 2020

Pharmacokinetics and biotransformation of mirtazapine in human volunteers

1 reference

12 December 2020

The relationship between paroxetine and the sparteine oxidation polymorphism

1 reference

12 December 2020

Bioactivities, estrogen receptor interactions, and plasminogen activator-inducing activities of tamoxifen and hydroxy-tamoxifen isomers in MCF-7 human breast cancer cells.

1 reference

12 December 2020

Combined effects of itraconazole and CYP2D6*10 genetic polymorphism on the pharmacokinetics and pharmacodynamics of haloperidol in healthy subjects

1 reference

12 December 2020

Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors

1 reference

12 December 2020

Polymorphism of human cytochrome P450 enzymes and its clinical impact

1 reference

12 December 2020

Pharmacogenetic aspects of therapy with cholinesterase inhibitors: the role of CYP2D6 in Alzheimer's disease pharmacogenetics

1 reference

12 December 2020

Isolation and identification of clozapine metabolites in patient urine.

1 reference

12 December 2020

Diphenhydramine versus nonsedating antihistamines for acute allergic reactions: a literature review

1 reference

12 December 2020

Venlafaxine. A review of its pharmacology and therapeutic potential in depression

1 reference

12 December 2020

Loratadine. A reappraisal of its pharmacological properties and therapeutic use in allergic disorders

1 reference

12 December 2020

Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I.

1 reference

12 December 2020

Atomoxetine: a review of its use in adults with attention deficit hyperactivity disorder

1 reference

12 December 2020

Identification of human P450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its kinetic parameters and inhibition constants

1 reference

12 December 2020

Steady state plasma levels of the enantiomers of trimipramine and of its metabolites in CYP2D6-, CYP2C19- and CYP3A4/5-phenotyped patients

1 reference

12 December 2020

Escitalopram (S-citalopram) and its metabolites in vitro: cytochromes mediating biotransformation, inhibitory effects, and comparison to R-citalopram

1 reference

12 December 2020

Steady-state serum concentrations of the neuroleptic perphenazine in relation to CYP2D6 genetic polymorphism

1 reference

12 December 2020

Metabolism of antidepressant and neuroleptic drugs by cytochrome p450s: clinical and interethnic aspects

1 reference

12 December 2020

The influence of the CYP2D6 polymorphism on psychopathological and extrapyramidal symptoms in the patients on long-term antipsychotic treatment.

1 reference

12 December 2020

Chlorpheniramine plasma concentration and histamine H1-receptor occupancy.

1 reference

12 December 2020

Food does not influence the pharmacokinetics of a new extended release formulation of tolterodine for once daily treatment of patients with overactive bladder

1 reference

12 December 2020

The analgesic effect of tramadol after intravenous injection in healthy volunteers in relation to CYP2D6.

1 reference

12 December 2020

Haloperidol disposition is dependent on the debrisoquine hydroxylation phenotype: increased plasma levels of the reduced metabolite in poor metabolizers

1 reference

12 December 2020

Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of dolasetron. Comparison with other indole-containing 5-HT3 antagonists

1 reference

12 December 2020

Dextromethorphan phenotyping and haloperidol disposition in schizophrenic patients

1 reference

12 December 2020

Selective estrogen modulators as an anticancer tool: mechanisms of efficiency and resistance.

1 reference

12 December 2020

Donepezil for the symptomatic treatment of patients with mild to moderate Alzheimer's disease: a meta-analysis of individual patient data from randomised controlled trials

1 reference

12 December 2020

Codeine and morphine in extensive and poor metabolizers of sparteine: pharmacokinetics, analgesic effect and side effects

1 reference

12 December 2020

Venlafaxine serum levels and CYP2D6 genotype

1 reference

12 December 2020

Miotic action of tramadol is determined by CYP2D6 genotype.

1 reference

12 December 2020

Increased plasma concentration of maprotiline by coadministration of risperidone

1 reference

12 December 2020

Biotransformation of mianserin in laboratory animals and man.

1 reference

12 December 2020

Identification of the human cytochrome P450 isoforms mediating in vitro N-dealkylation of perphenazine

1 reference

12 December 2020

Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.

1 reference

12 December 2020

Increased (R)-Methadone Plasma Concentrations by Quetiapine in Cytochrome P450s and ABCB1 Genotyped Patients

1 reference

12 December 2020

Involvement of CYP2D6 in oxidative metabolism of cinnarizine and flunarizine in human liver microsomes

1 reference

12 December 2020

Identification of the human cytochromes P450 responsible for atomoxetine metabolism

1 reference

12 December 2020

Population pharmacokinetic modelling of aripiprazole and its active metabolite, dehydroaripiprazole, in psychiatric patients

1 reference

12 December 2020

Pharmacogenetics of opioids

1 reference

12 December 2020

Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population

1 reference

12 December 2020

Hydroxylation and demethylation of the tricyclic antidepressant nortriptyline by cDNA-expressed human cytochrome P-450 isozymes

1 reference

12 December 2020

Amitriptyline or not, that is the question: pharmacogenetic testing of CYP2D6 and CYP2C19 identifies patients with low or high risk for side effects in amitriptyline therapy

1 reference

12 December 2020

Clinical pharmacokinetics of clomipramine

1 reference

12 December 2020

A review of oxycodone's clinical pharmacokinetics and pharmacodynamics

1 reference

12 December 2020

Quinidine inhibits the 7-hydroxylation of chlorpromazine in extensive metabolisers of debrisoquine

1 reference

12 December 2020

Venlafaxine oxidation in vitro is catalysed by CYP2D6.

1 reference

12 December 2020

Non-linear fluvoxamine disposition

1 reference

12 December 2020

Endogenous codeine and morphine in poor and extensive metabolisers of the CYP2D6 (debrisoquine/sparteine) polymorphism

1 reference

12 December 2020

The effect of cytochrome P450 2D6 genotypes on haloperidol metabolism: a preliminary study in a psychiatric population

1 reference

12 December 2020

Active hydroxymetabolites of antidepressants. Emphasis on E-10-hydroxy-nortriptyline

1 reference

12 December 2020

Cytochrome p450 phenotyping/genotyping in patients receiving antipsychotics: useful aid to prescribing?

1 reference

12 December 2020

Influence of oxidation polymorphism on phenformin kinetics and dynamics

1 reference

12 December 2020

Clinically relevant pharmacokinetic drug interactions with second-generation antidepressants: an update

1 reference

12 December 2020

The role of active metabolites in dihydrocodeine effects

1 reference

12 December 2020

Cytochrome P450 2D6 genotype variation and venlafaxine dosage

1 reference

12 December 2020

Phenformin-induced lacticacidosis associated with impaired debrisoquine hydroxylation

1 reference

12 December 2020

Haloperidol disposition is dependent on debrisoquine hydroxylation phenotype

1 reference

12 December 2020

Single-dose kinetics of clomipramine: relationship to the sparteine and S-mephenytoin oxidation polymorphisms

1 reference

12 December 2020

Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine

1 reference

12 December 2020

The clinical features and new biological roles of trimipramine

1 reference

12 December 2020

Plasma levels of thioridazine and metabolites are influenced by the debrisoquin hydroxylation phenotype

1 reference

12 December 2020

Influence of the CYP2D6*4 polymorphism on dose, switching and discontinuation of antidepressants

1 reference

12 December 2020

Antipsychotic-induced hyperprolactinaemia: mechanisms, clinical features and management

1 reference

12 December 2020

Microsomal binding of amitriptyline: effect on estimation of enzyme kinetic parameters in vitro.

1 reference

12 December 2020

Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes

1 reference

12 December 2020

Metabolism and elimination of 14C-donepezil in healthy volunteers: a single-dose study

1 reference

12 December 2020

Isolation and identification of hydroxylated maprotiline metabolites

1 reference

12 December 2020

Pharmacokinetics and metabolism of the 5-hydroxytryptamine antagonist tropisetron after single oral doses in humans

1 reference

12 December 2020

Fluoxetine metabolism and pharmacological interactions: the role of cytochrome p450

1 reference

12 December 2020

Steady-state plasma levels of clomipramine and its metabolites: impact of the sparteine/debrisoquine oxidation polymorphism. Danish University Antidepressant Group.

1 reference

12 December 2020

Effect of a CYP2D6 polymorphism on the efficacy of donepezil in patients with Alzheimer disease

1 reference

12 December 2020

Atomoxetine: the first nonstimulant for the management of attention-deficit/hyperactivity disorder.

1 reference

12 December 2020

Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes

1 reference

12 December 2020

1 reference

12 December 2020

Inhibitors of cytochrome P450 differentially modify discriminative-stimulus and antinociceptive effects of hydrocodone and hydromorphone in rhesus monkeys.

1 reference

12 December 2020

QTc interval lengthening is related to CYP2D6 hydroxylation capacity and plasma concentration of thioridazine in patients

1 reference

12 December 2020

Contributions of five human cytochrome P450 isoforms to the N-demethylation of clozapine in vitro at low and high concentrations

1 reference

12 December 2020

Association of graded allele-specific changes in CYP2D6 function with imipramine dose requirement in a large group of depressed patients

1 reference

12 December 2020

Effects of the CYP2D6 gene duplication on the pharmacokinetics and pharmacodynamics of tramadol.

1 reference

12 December 2020

Overview of the pharmacokinetics of fluvoxamine

1 reference

12 December 2020

CYP2D6 polymorphisms and the impact on tamoxifen therapy

1 reference

12 December 2020

The major fluvoxamine metabolite in urine is formed by CYP2D6.

1 reference

12 December 2020

Pharmacokinetics of the selective serotonin reuptake inhibitor paroxetine: Nonlinearity and relation to the sparteine oxidation polymorphism

1 reference

12 December 2020

Fluoxetine inhibits the metabolism of tolterodine-pharmacokinetic implications and proposed clinical relevance

1 reference

12 December 2020

Disposition of the neuroleptic zuclopenthixol cosegregates with the polymorphic hydroxylation of debrisoquine in humans

1 reference

12 December 2020

Plasma concentrations of risperidone and 9-hydroxyrisperidone during combined treatment with paroxetine

1 reference

12 December 2020

Vascular dementia: pharmacological treatment approaches and perspectives

1 reference

12 December 2020

Effects of the CYP2D6 genotype on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese schizophrenic patients

1 reference

12 December 2020

Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation

1 reference

12 December 2020

N+-Glucuronidation of aliphatic tertiary amines, a general phenomenon in the metabolism of H1-antihistamines in humans

1 reference

12 December 2020

Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials

1 reference

12 December 2020

Perphenazine for schizophrenia

1 reference

12 December 2020

1 reference

12 December 2020

Multiple dose pharmacokinetics of a new once daily extended release tolterodine formulation versus immediate release tolterodine

1 reference

12 December 2020

Influence of itraconazole co-administration and CYP2D6 genotype on the pharmacokinetics of the new antipsychotic ARIPIPRAZOLE.

1 reference

12 December 2020

CYP2D6 is primarily responsible for the metabolism of clomiphene

1 reference

12 December 2020

The CYP2D6 poor metabolizer phenotype may be associated with risperidone adverse drug reactions and discontinuation

1 reference

12 December 2020

Impact of the CYP2D6 genotype on steady-state serum concentrations of aripiprazole and dehydroaripiprazole

1 reference

12 December 2020

Population pharmacokinetic modelling of tramadol with application of the NPEM algorithms

1 reference

12 December 2020

Fluvoxamine. An updated review of its pharmacology, and therapeutic use in depressive illness

1 reference

12 December 2020

Clinical pharmacokinetics of imipramine and desipramine

1 reference

12 December 2020

The impact of the CYP2D6 and CYP2C19 genotypes on venlafaxine pharmacokinetics in a Japanese population

1 reference

12 December 2020

Studies on the metabolism of ergoline derivatives. Metabolism of nicergoline in man and in animals

1 reference

12 December 2020

Antimuscarinic potency and bladder selectivity of PNU-200577, a major metabolite of tolterodine

1 reference

12 December 2020

A PET study of D2 and 5-HT2 receptor occupancy induced by risperidone in poor metabolizers of debrisoquin and risperidone

1 reference

12 December 2020

The identification of urinary metabolites of doxepin in patients

1 reference

12 December 2020

Clinical pharmacogenetics and potential application in personalized medicine

1 reference

12 December 2020

In-vitro characterization of the cytochrome P450 isoenzymes involved in the back oxidation and N-dealkylation of reduced haloperidol.

1 reference

12 December 2020

Pharmacokinetic Optimisation of Oral Hypoglycaemic Therapy

1 reference

12 December 2020

Dolasetron. A review of its pharmacology and therapeutic potential in the management of nausea and vomiting induced by chemotherapy, radiotherapy or surgery

1 reference

12 December 2020

Enantioselective hydroxylation of nortriptyline in human liver microsomes, intestinal homogenate, and patients treated with nortriptyline

1 reference

12 December 2020

Trimipramine and maprotiline plasma levels during combined treatment with moclobemide in therapy-resistant depression

1 reference

12 December 2020

Atomoxetine in the treatment of children and adolescents with attention-deficit/hyperactivity disorder: a randomized, placebo-controlled, dose-response study

1 reference

12 December 2020

The O-demethylation of the antidementia drug galanthamine is catalysed by cytochrome P450 2D6

1 reference

12 December 2020

Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine

1 reference

12 December 2020

Differences in the inhibitory effect of cimetidine on desipramine metabolism between rapid and slow debrisoquin hydroxylators

1 reference

12 December 2020

Polymorphic CYP2D6 mediates O-demethylation of the opioid analgesic tramadol

1 reference

12 December 2020

Imipramine N-glucuronidation in human liver microsomes: biphasic kinetics and characterization of UDP-glucuronosyltransferase isoforms

1 reference

12 December 2020

Influence of CYP2D6 polymorphism on the pharmacokinetics and pharmacodynamic of tolterodine.

1 reference

12 December 2020

Tropisetron: an update of its use in the prevention of chemotherapy-induced nausea and vomiting

1 reference

12 December 2020

Clinical originality and new biology of trimipramine

1 reference

12 December 2020

Clinically Relevant Pharmacology of Selective Serotonin Reuptake Inhibitors

1 reference

12 December 2020

10.2165/11318070-000000000-00000

Identifiers

DOI

1 reference

PubMed ID

19902987

Dimensions Publication ID

17 November 2017

0 references

1 reference

PubMed ID

19902987