Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review (Q33345319)

26 July 2017

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title

Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review (English)

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26 July 2017

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Nicolas Roche

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Philippe Devillier

series ordinal

1

object named as

Philippe Devillier

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26 July 2017

3

Christophe Faisy

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26 July 2017

1 January 2008

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Clinical Pharmacokinetics

26 July 2017

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26 July 2017

47

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26 July 2017

217-230

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26 July 2017

4

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https://scigraph.springernature.com/pub.10.2165/00003088-200847040-00001

26 July 2017

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12 December 2020

A single-center, randomized, double-blind, placebo-controlled, crossover investigation of the effects of fexofenadine hydrochloride 180 mg alone and with alcohol, with hydroxyzine hydrochloride 50 mg as a positive internal control, on aspects of cog

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12 December 2020

Clinical pharmacology of new histamine H1 receptor antagonists

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12 December 2020

The effect of 4 weeks treatment with desloratadine (5mg daily) on levels of interleukin (IL)-4, IL-10, IL-18 and TGF beta in patients suffering from seasonal allergic rhinitis

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12 December 2020

Anti-inflammatory properties of desloratadine

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12 December 2020

Levocetirizine in 1-2 year old children: pharmacokinetic and pharmacodynamic profile.

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12 December 2020

Population pharmacokinetics of levocetirizine in very young children: the pediatricians' perspective

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12 December 2020

Inhibitory activity of loratadine and descarboxyethoxyloratadine on histamine-induced activation of endothelial cells

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12 December 2020

Levocetirizine: pharmacokinetics and pharmacodynamics in children age 6 to 11 years

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12 December 2020

Comparative onset of action and symptom relief with cetirizine, loratadine, or placebo in an environmental exposure unit in subjects with seasonal allergic rhinitis: confirmation of a test system

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12 December 2020

Appraisal of the validity of histamine-induced wheal and flare to predict the clinical efficacy of antihistamines

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12 December 2020

Pharmacokinetic and safety profile of desloratadine and fexofenadine when coadministered with azithromycin: a randomized, placebo-controlled, parallel-group study

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12 December 2020

Comparison of the risk of drowsiness and sedation between levocetirizine and desloratadine: a prescription-event monitoring study in England.

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12 December 2020

Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes

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12 December 2020

Histamine: A mediator of inflammation

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12 December 2020

Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family

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12 December 2020

The histamine H4 receptor as a new therapeutic target for inflammation

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12 December 2020

Absorption, distribution, metabolism and excretion of [14C]levocetirizine, the R enantiomer of cetirizine, in healthy volunteers

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12 December 2020

Histamine influences the expression of the interleukin-6 receptor on human lymphoid, monocytoid and hepatoma cell lines.

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12 December 2020

The clinical pharmacology of fexofenadine in children

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12 December 2020

Effect of race and sex on single and multiple dose pharmacokinetics of desloratadine

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12 December 2020

Constitutive activity of the histamine H(1) receptor reveals inverse agonism of histamine H(1) receptor antagonists

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12 December 2020

Loratadine and desethoxylcarbonyl-loratadine inhibit the immunological release of mediators from human Fc epsilon RI+ cells

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12 December 2020

Lack of effect of single and repeated doses of levocetirizine, a new antihistamine drug, on cognitive and psychomotor functions in healthy volunteers

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12 December 2020

P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists

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12 December 2020

Lack of clinically relevant interaction between desloratadine and erythromycin

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12 December 2020

Evaluation of pharmacokinetic interaction between cetirizine and ritonavir, an HIV-1 protease inhibitor, in healthy male volunteers

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12 December 2020

Onset and duration of the effects of three antihistamines in current use--astemizole, loratadine and terfenadine forte--studied during prolonged, controlled allergen challenges in volunteers

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12 December 2020

The acute and sub-chronic effects of levocetirizine, cetirizine, loratadine, promethazine and placebo on cognitive function, psychomotor performance, and weal and flare

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12 December 2020

Co-localization of histamine and dopamine-beta-hydroxylase in sympathetic ganglion and release of histamine from cardiac sympathetic terminals of guinea-pig

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12 December 2020

A new antihistamine levocetirizine inhibits eosinophil adhesion to vascular cell adhesion molecule-1 under flow conditions

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12 December 2020

Driving ability after acute and sub-chronic administration of levocetirizine and diphenhydramine: a randomized, double-blind, placebo-controlled trial

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12 December 2020

Comparative efficacy of cetirizine and fexofenadine for seasonal allergic rhinitis, 5-12 hours postdose, in the environmental exposure unit.

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12 December 2020

H1-antihistamines: inverse agonism, anti-inflammatory actions and cardiac effects

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12 December 2020

Histamine enhances interleukin (IL)-1-induced IL-1 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells. Comparison with IL-1 receptor antagonist

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12 December 2020

The histamine-induced enhanced expression of vascular cell adhesion molecule-1 by nasal polyp-derived fibroblasts is inhibited by levocetirizine

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12 December 2020

The histamine H3 receptor as a novel therapeutic target for cognitive and sleep disorders

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12 December 2020

Hepatic disposition of fexofenadine: influence of the transport inhibitors erythromycin and dibromosulphothalein

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12 December 2020

Twenty-four hours of activity of cetirizine and fexofenadine in the skin

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12 December 2020

Antihistamines added to an antileukotriene in treating seasonal allergic rhinitis: histamine and leukotriene antagonism.

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12 December 2020

Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides

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12 December 2020

Effects of bepotastine, cetirizine, fexofenadine, and olopatadine on histamine-induced wheal-and flare-response, sedation, and psychomotor performance

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12 December 2020

Abnormal functional and morphological regulation of the gastric mucosa in histamine H2 receptor-deficient mice

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12 December 2020

The pharmacologic profile of desloratadine: a review

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12 December 2020

Adult and paediatric poor metabolisers of desloratadine: an assessment of pharmacokinetics and safety

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12 December 2020

Validation of a histamine H3 receptor model through structure-activity relationships for classical H3 antagonists

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12 December 2020

Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors

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12 December 2020

Molecular cloning of a gene encoding the histamine H2 receptor

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12 December 2020

Influx and efflux transport of H1-antagonist epinastine across the blood-brain barrier

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12 December 2020

Allergic rhinitis and its impact on asthma

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12 December 2020

Acute and subchronic effects of levocetirizine and diphenhydramine on memory functioning, psychomotor performance, and mood

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12 December 2020

Absorption and disposition of levocetirizine, the eutomer of cetirizine, administered alone or as cetirizine to healthy volunteers

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12 December 2020

The effect of fexofenadine on expression of intercellular adhesion molecule 1 and induction of apoptosis on peripheral eosinophils

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12 December 2020

Central nervous system effects of H1-receptor antagonists in the elderly

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12 December 2020

A direct comparison of the efficacy of antihistamines in SAR and PAR: randomised, placebo-controlled studies with levocetirizine and loratadine using an environmental exposure unit - the Vienna Challenge Chamber (VCC).

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12 December 2020

Cloning and functional expression of the human histamine H3 receptor

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12 December 2020

Chromosomal localization of the human histamine H1-receptor gene

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12 December 2020

Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography

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12 December 2020

Immune regulation by histamine

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12 December 2020

Comparative clinical efficacy, onset and duration of action of levocetirizine and desloratadine for symptoms of seasonal allergic rhinitis in subjects evaluated in the Environmental Exposure Unit (EEU).

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12 December 2020

Inhibition of cytokine secretion from human leukemic mast cells and basophils by H1- and H2-receptor antagonists

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12 December 2020

Histamine induces interleukin-8 secretion by endothelial cells

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12 December 2020

Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine

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12 December 2020

The metabolic profile of second-generation antihistamines

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12 December 2020

Cetirizine and levocetirizine inhibit eotaxin-induced eosinophil transendothelial migration through human dermal or lung microvascular endothelial cells

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12 December 2020

Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus

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12 December 2020

Second-generation antihistamines: actions and efficacy in the management of allergic disorders

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12 December 2020

Onset of action and efficacy of terfenadine, astemizole, cetirizine, and loratadine for the relief of symptoms of allergic rhinitis.

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12 December 2020

Intestinal drug transporter expression and the impact of grapefruit juice in humans

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12 December 2020

Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis

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12 December 2020

Brain histamine H receptor occupancy of orally administered antihistamines measured by positron emission tomography with (11)C-doxepin in a placebo-controlled crossover study design in healthy subjects: a comparison of olopatadine and ketotifen.

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12 December 2020

Why are non-sedating antihistamines non-sedating?

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12 December 2020

Cetirizine, loratadine, or placebo in subjects with seasonal allergic rhinitis: effects after controlled ragweed pollen challenge in an environmental exposure unit

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12 December 2020

Comparing the new antihistamines: the role of pharmacological parameters

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12 December 2020

Pharmacokinetic overview of oral second-generation H1 antihistamines.

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12 December 2020

Histamine receptors are hot in immunopharmacology

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12 December 2020

Desloratadine has no clinically relevant electrocardiographic or pharmacodynamic interactions with ketoconazole

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12 December 2020

Advances in H1-antihistamines

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12 December 2020

Antagonistic targeting of the histamine H3 receptor decreases caloric intake in higher mammalian species.

1 reference

12 December 2020

A pharmacokinetic profile of desloratadine in healthy adults, including elderly

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12 December 2020

Biochemical characterization of desloratadine, a potent antagonist of the human histamine H(1) receptor

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12 December 2020

Anticholinergic effects of desloratadine, the major metabolite of loratadine, in rabbit and guinea-pig iris smooth muscle

1 reference

12 December 2020

Twenty-four-hour activity and consistency of activity of levocetirizine and desloratadine in the skin

1 reference

12 December 2020

Grapefruit juice reduces the oral bioavailability of fexofenadine but not desloratadine

1 reference

12 December 2020

A case of the toxicity of pilsicainide hydrochloride with comparison of the serial serum pilsicainide levels and electrocardiographic findings

1 reference

12 December 2020

Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine

1 reference

12 December 2020

Long QT syndrome in a patient with allergic rhinoconjunctivitis and auto-immune diabetes: focus on the choice of anti-H1 drugs

1 reference

12 December 2020

Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus

1 reference

12 December 2020

Inhibition of the histamine-induced weal and flare response: a valid surrogate measure for antihistamine clinical efficacy?

1 reference

12 December 2020

Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in Balb C mice

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12 December 2020

Effect of St John's wort on the pharmacokinetics of fexofenadine

1 reference

12 December 2020

Inhibition of chemical and low-intensity mechanical nociception by activation of histamine H3 receptors

1 reference

12 December 2020

H1 antagonists: receptor affinity versus selectivity

1 reference

12 December 2020

Pharmacological modulation of IL-6 and IL-8 secretion by the H1-antagonist decarboethoxy-loratadine and dexamethasone by human mast and basophilic cell lines

1 reference

12 December 2020

Binding characteristics of cetirizine and levocetirizine to human H(1) histamine receptors: contribution of Lys(191) and Thr(194).

1 reference

12 December 2020

Desloratadine inhibits constitutive and histamine-stimulated nuclear factor-kappaB activity consistent with inverse agonism at the histamine H1 Receptor.

1 reference

12 December 2020

Involvement of histamine released from mast cells in acute radiation dermatitis in mice.

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12 December 2020

Pharmacokinetics of desloratadine in children between 2 and 11 years of age

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12 December 2020

Suppressive activity of fexofenadine hydrochloride on the production of eosinophil chemoattractants from human nasal fibroblasts in vitro

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12 December 2020

Histamine in the immune regulation of allergic inflammation

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12 December 2020

Comparison of the effects in the nose and skin of a single dose of desloratadine and levocetirizine over 24 hours

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12 December 2020

Effects of first and second generation antihistamines on muscarinic induced mucus gland cell ion transport

1 reference

12 December 2020

Pharmacokinetics/pharmacodynamics of desloratadine and fluoxetine in healthy volunteers

1 reference

12 December 2020

Desloratadine dose selection in children aged 6 months to 2 years: comparison of population pharmacokinetics between children and adults

1 reference

12 December 2020

Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein

1 reference

12 December 2020

Modulation of neurotransmitter release via histamine H3 heteroreceptors

1 reference

12 December 2020

OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine

1 reference

12 December 2020

Time-Dependent Interaction Between Lopinavir/Ritonavir and Fexofenadine

1 reference

12 December 2020

Preclinical pharmacology of desloratadine, a selective and nonsedating histamine H1 receptor antagonist. 2nd communication: lack of central nervous system and cardiovascular effects

1 reference

12 December 2020

Activation of histamine H3 receptors in human nasal mucosa inhibits sympathetic vasoconstriction

1 reference

12 December 2020

Preclinical pharmacology of desloratadine, a selective and nonsedating histamine H1 receptor antagonist. 1st communication: receptor selectivity, antihistaminic activity, and antiallergenic effects.

1 reference

12 December 2020

The effect of ketoconazole on the in vivo intestinal permeability of fexofenadine using a regional perfusion technique

1 reference

12 December 2020

Severe arrhythmia as a result of the interaction of cetirizine and pilsicainide in a patient with renal insufficiency: first case presentation showing competition for excretion via renal multidrug resistance protein 1 and organic cation transporter

1 reference

12 December 2020

Randomized double-blind comparison of cetirizine and fexofenadine after pollen challenge in the Environmental Exposure Unit: duration of effect in subjects with seasonal allergic rhinitis.

1 reference

12 December 2020

In vitro characterization of the inhibition profile of loratadine, desloratadine, and 3-OH-desloratadine for five human cytochrome P-450 enzymes

1 reference

12 December 2020

A double-blind, randomized, single-dose, crossover comparison of levocetirizine with ebastine, fexofenadine, loratadine, mizolastine, and placebo: suppression of histamine-induced wheal-and-flare response during 24 hours in healthy male subjects

1 reference

12 December 2020

Onset of action in the nasal antihistaminic effect of cetirizine and loratadine in patients with allergic rhinitis

1 reference

12 December 2020

H1 histamine receptor mediates inflammatory responses in human keratinocytes

1 reference

12 December 2020

Changes in pH differently affect the binding properties of histamine H1 receptor antagonists

1 reference

12 December 2020

Molecular properties and pharmacokinetic behavior of cetirizine, a zwitterionic H1-receptor antagonist.

1 reference

12 December 2020

Clinical pharmacology of H1-antihistamines in the skin

1 reference

12 December 2020

Histamine H(1)-receptor activation of nuclear factor-kappa B: roles for G beta gamma- and G alpha(q/11)-subunits in constitutive and agonist-mediated signaling.

1 reference

12 December 2020

Critical Role of Histamine H4Receptor in Leukotriene B4Production and Mast Cell-Dependent Neutrophil Recruitment Induced by Zymosan in Vivo

1 reference

12 December 2020

Effects of desloratadine, diphenhydramine, and placebo on driving performance and psychomotor performance measurements

1 reference

12 December 2020

Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans

1 reference

12 December 2020

10.2165/00003088-200847040-00001

Identifiers

DOI

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PubMed ID

18336052

Dimensions Publication ID

26 July 2017

0 references

1 reference

PubMed ID

18336052