A discordance between cytochrome P450 2D6 genotype and phenotype in patients undergoing methadone maintenance treatment (Q35825489)

10 August 2017

A discordance between cytochrome P450 2D6 genotype and phenotype in patients undergoing methadone maintenance treatment (English)

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10 August 2017

M R Shiran

1

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10 August 2017

J Chowdry

2

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10 August 2017

A Rostami-Hodjegan

3

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10 August 2017

S W Ellis

4

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10 August 2017

M S Lennard

5

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10 August 2017

M Z Iqbal

6

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10 August 2017

O Lagundoye

7

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10 August 2017

N Seivewright

8

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10 August 2017

G T Tucker

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10 August 2017

language of work or name

English

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publication date

1 August 2003

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British Journal of Clinical Pharmacology

10 August 2017

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10 August 2017

56

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10 August 2017

2

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10 August 2017

220-224

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

10 August 2017

1 reference

Steady-state pharmacokinetics of (R)- and (S)-methadone in methadone maintenance patients.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

Population pharmacokinetics of methadone in opiate users: characterization of time-dependent changes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

Methadone N-demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

Novel single-point plasma or saliva dextromethorphan method for determining CYP2D6 activity.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

Inhibition of human cytochrome P450 2D6 (CYP2D6) by methadone

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

Pharmacogenetic phenotyping and genotyping. Present status and future potential.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

"It's the genes, stupid". Molecular bases and clinical consequences of genetic cytochrome P450 2D6 polymorphism

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

Single dose pharmacokinetics and bioavailability of methadone in man studied with a stable isotope method

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

Quinidine: potent inhibition of sparteine and debrisoquine oxidation in vivo.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

Sparteine oxidation is practically abolished in quinidine-treated patients

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

Dextromethorphan: polymorphic serum pattern of the O-demethylated and didemethylated metabolites in man.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

Simultaneous determination of dextromethorphan and three metabolites in plasma and urine using high-performance liquid chromatography with application to their disposition in man.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

The genetic polymorphism of debrisoquine/sparteine metabolism--clinical aspects

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

Identification of the primary gene defect at the cytochrome P450 CYP2D locus.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

The human hepatic cytochromes P450 involved in drug metabolism

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

Summary of information on human CYP enzymes: human P450 metabolism data

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

Determinants of interindividual variability and extent of CYP2D6 and CYP1A2 inhibition by paroxetine and fluvoxamine in vivo.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

Pharmacokinetics of methadone and its primary metabolite in 20 opiate addicts.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884285

The roles of P-glycoprotein and intracellular metabolism in the intestinal absorption of methadone: in vitro studies using the rat everted intestinal sac

24 September 2018

1 reference

12 December 2020

Inhibition of desipramine 2-hydroxylation by quinidine and quinine

1 reference

12 December 2020

Quinidine inhibits the 2-hydroxylation of imipramine and desipramine but not the demethylation of imipramine

1 reference

12 December 2020

Desipramine and its 2-hydroxy metabolite in patients taking or not taking methadone

1 reference

12 December 2020

Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease

1 reference

12 December 2020

Regioselective hydroxylation of debrisoquine by cytochrome P4502D6: implications for active site modelling

1 reference

12 December 2020

In-vivo indices of CYP2D6 activity: comparison of dextromethorphan metabolic ratios in 4-h urine and 3-h plasma

1 reference

12 December 2020

Cytochrome P450 2D6 Genotype and Methadone Steady-State Concentrations

1 reference

12 December 2020

Single-dose quinidine treatment inhibits metoprolol oxidation in extensive metabolizers

1 reference

12 December 2020

CYP2D6- and CYP3A-dependent metabolism of dextromethorphan in humans

1 reference

12 December 2020

An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution

1 reference

12 December 2020

Extensive metabolizers of debrisoquine become poor metabolizers during quinidine treatment

1 reference

12 December 2020

10.1046/J.1365-2125.2003.01851.X

Identifiers

DOI

1 reference

10 August 2017

1 reference

10 August 2017

1 reference