Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I. (Q37611786)

21 August 2017

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title

Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I. (English)

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21 August 2017

Shu-Feng Zhou

1

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21 August 2017

1 January 2009

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Clinical Pharmacokinetics

21 August 2017

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21 August 2017

48

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21 August 2017

689-723

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21 August 2017

11

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https://scigraph.springernature.com/pub.10.2165/11318030-000000000-00000

21 August 2017

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Clinical implications of pharmacogenetics of cytochrome P450 drug metabolizing enzymes

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Chromosomal assignment of human cytochrome P-450 (debrisoquine/sparteine type) to chromosome 22.

21 January 2018

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The influence of enzyme induction on polymorphic sparteine oxidation

21 January 2018

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Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

21 January 2018

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The role of cytochrome P4502D6 in the metabolism of paroxetine by human liver microsomes

21 January 2018

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A Review of the Pharmacological and Clinical Profile of Mirtazapine

21 January 2018

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The effect of enzyme inhibition on the metabolism and activation of tacrine by human liver microsomes

21 January 2018

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Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine

21 January 2018

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Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine

21 January 2018

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An investigation of the interaction between halofantrine, CYP2D6 and CYP3A4: studies with human liver microsomes and heterologous enzyme expression systems

21 January 2018

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Dextromethorphan and caffeine as probes for simultaneous determination of debrisoquin-oxidation and N-acetylation phenotypes in children

21 January 2018

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Single-dose and steady-state pharmacokinetics of tomoxetine in normal subjects.

21 January 2018

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First-pass metabolism of imipramine in man

21 January 2018

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The metabolism of aprindine in relation to the sparteine/debrisoquine polymorphism

21 January 2018

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An unequal cross-over event within the CYP2D gene cluster generates a chimeric CYP2D7/CYP2D6 gene which is associated with the poor metabolizer phenotype

21 January 2018

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Metoprolol oxidation polymorphism in a Korean population: comparison with native Japanese and Chinese populations

21 January 2018

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Correlations among the metabolic ratios of three test probes (metoprolol, debrisoquine and sparteine) for genetically determined oxidation polymorphism in a Japanese population

21 January 2018

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Lower prevalence of the debrisoquin oxidative poor metabolizer phenotype in American black versus white subjects

21 January 2018

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Low frequency of defective alleles of cytochrome P450 enzymes 2C19 and 2D6 in the Turkish population

21 January 2018

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21 January 2018

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Efficacy and safety of perhexiline maleate in refractory angina. A double-blind placebo-controlled clinical trial of a novel antianginal agent

21 January 2018

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In vitro characterization of the human cytochrome P-450 involved in polymorphic oxidation of propafenone

21 January 2018

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Clomipramine vs desipramine vs placebo in the treatment of diabetic neuropathy symptoms. A double-blind cross-over study.

21 January 2018

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Hydroxylation of desmethylimipramine: dependence on the debrisoquin hydroxylation phenotype

21 January 2018

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The influence of the sparteine/debrisoquin phenotype on the disposition of flecainide

21 January 2018

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Maprotiline metabolism appears to co-segregate with the genetically-determined CYP2D6 polymorphic hydroxylation of debrisoquine

21 January 2018

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Differential stereoselective metabolism of metoprolol in extensive and poor debrisoquin metabolizers

21 January 2018

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Defective metabolism of metoprolol in poor hydroxylators of debrisoquine

21 January 2018

1 reference

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The metabolism of mexiletine in relation to the debrisoquine/sparteine-type polymorphism of drug oxidation

21 January 2018

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Timolol and atenolol: relationships between oxidation phenotype, pharmacokinetics and pharmacodynamics

21 January 2018

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https://api.crossref.org/works/10.2165%2F11318030-000000000-00000

Stereoselective disposition of flecainide in relation to the sparteine/debrisoquine metaboliser phenotype

21 January 2018

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https://api.crossref.org/works/10.2165%2F11318030-000000000-00000

Stereoselective genetically-determined interaction between chronic flecainide and quinidine in patients with arrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318030-000000000-00000

Stereoselective disposition and pharmacologic activity of propafenone enantiomers

21 January 2018

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https://api.crossref.org/works/10.2165%2F11318030-000000000-00000

The pharmacokinetic and pharmacodynamic interaction between propafenone and lidocaine.

21 January 2018

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https://api.crossref.org/works/10.2165%2F11318030-000000000-00000

Drug interaction between propafenone and metoprolol

21 January 2018

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https://api.crossref.org/works/10.2165%2F11318030-000000000-00000

Pharmacokinetics of novel atrial-selective antiarrhythmic agent vernakalant hydrochloride injection (RSD1235): influence of CYP2D6 expression and other factors

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318030-000000000-00000

Metoprolol metabolism and debrisoquine oxidation polymorphism--population and family studies

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318030-000000000-00000

The relationship between debrisoquine oxidation phenotype and the pharmacokinetics and pharmacodynamics of propranolol

21 January 2018

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https://api.crossref.org/works/10.2165%2F11318030-000000000-00000

The oral clearance and beta-adrenoceptor antagonist activity of propranolol after single dose are not related to debrisoquine oxidation phenotype

21 January 2018

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β-Blocking effects of timolol at low plasma concentrations

21 January 2018

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https://api.crossref.org/works/10.2165%2F11318030-000000000-00000

Medical implications of HGP's sequence of chromosome 22

21 January 2018

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12 December 2020

Effect of CYP2D6*10 on the pharmacokinetics of R- and S-carvedilol in healthy Japanese volunteers

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12 December 2020

Potent Inhibition of Cytochrome P450IID6 (Debrisoquin 4-Hydroxylase) by Flecainide In Vitro and In Vivo

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12 December 2020

Role of cytochrome P450 2D6 (CYP2D6) in the stereospecific metabolism of E- and Z-doxepin

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12 December 2020

CYP1A2 and CYP2D6 4-hydroxylate propranolol and both reactions exhibit racial differences

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12 December 2020

Stereoselective disposition of carvedilol is determined by CYP2D6

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12 December 2020

Impact of the ultrarapid metabolizer genotype of cytochrome P450 2D6 on metoprolol pharmacokinetics and pharmacodynamics

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12 December 2020

Polymorphisms of genes CYP2D6, ADRB1 and GNAS1 in pharmacokinetics and systemic effects of ophthalmic timolol. A pilot study

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12 December 2020

CYP2D6 genotype and induction of intestinal drug transporters by rifampin predict presystemic clearance of carvedilol in healthy subjects.

1 reference

12 December 2020

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

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12 December 2020

Minimizing polymorphic metabolism in drug discovery: evaluation of the utility of in vitro methods for predicting pharmacokinetic consequences associated with CYP2D6 metabolism

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12 December 2020

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

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12 December 2020

Relationship between plasma desipramine levels, CYP2D6 phenotype and clinical response to desipramine: a prospective study

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12 December 2020

The effects of tramadol on static and dynamic pupillometry in healthy subjects--the relationship between pharmacodynamics, pharmacokinetics and CYP2D6 metaboliser status

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12 December 2020

Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism

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12 December 2020

Disposition and metabolic fate of atomoxetine hydrochloride: the role of CYP2D6 in human disposition and metabolism

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12 December 2020

Isolation and structural characterization by spectroscopic methods of two glucuronide metabolites of mexiletine after N-oxidation and deamination

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12 December 2020

Timolol Metabolism in Human Liver Microsomes Is Mediated Principally by CYP2D6

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12 December 2020

A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity

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12 December 2020

Genetic basis for a lower prevalence of deficient CYP2D6 oxidative drug metabolism phenotypes in black Americans

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12 December 2020

A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine

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12 December 2020

Involvement of human cytochrome P450 3A4 in reduced haloperidol oxidation

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12 December 2020

Increased frequency of cytochrome P450 2D6 poor metabolizers among patients with metoprolol-associated adverse effects

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12 December 2020

Contributions of CYP2D6, CYP2C9 and CYP2C19 to the biotransformation of E- and Z-doxepin in healthy volunteers

1 reference

12 December 2020

CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status

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12 December 2020

Donepezil use in Alzheimer disease

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12 December 2020

Novel nonsynonymous single nucleotide polymorphisms in the CYP2D6 gene

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12 December 2020

Gepirone and 1-(2-pyrimidinyl)-piperazine in vitro: human cytochromes mediating transformation and cytochrome inhibitory effects

1 reference

12 December 2020

Quinidine-enhanced beta-blockade during treatment with propafenone in extensive metabolizer human subjects

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12 December 2020

Dextromethorphan O-demethylation in liver microsomes as a prototype reaction to monitor cytochrome P-450 db1 activity

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12 December 2020

Impact of CYP2D6 poor metabolizer phenotype on propranolol pharmacokinetics and response

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12 December 2020

The effect of impaired renal function on the plasma concentration and urinary excretion of metoprolol metabolites

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12 December 2020

Human cytochromes mediating N-demethylation of fluoxetine in vitro

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12 December 2020

The influence of environmental and genetic factors on CYP2D6, CYP1A2 and UDP-glucuronosyltransferases in man using sparteine, caffeine, and paracetamol as probes

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12 December 2020

Metoprolol: a review of its use in chronic heart failure

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12 December 2020

Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension

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12 December 2020

Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment

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12 December 2020

Sertraline N-demethylation is catalyzed by multiple isoforms of human cytochrome P-450 in vitro.

1 reference

12 December 2020

Metabolism of the analgesic drug ULTRAM (tramadol hydrochloride) in humans: API-MS and MS/MS characterization of metabolites

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12 December 2020

CYP2D6- and CYP3A-dependent metabolism of dextromethorphan in humans

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12 December 2020

The stereoselective metabolism of fluoxetine in poor and extensive metabolizers of sparteine

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12 December 2020

Effect of the CYP2D6 genotype on the pharmacokinetics of tropisetron in healthy Korean subjects.

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12 December 2020

Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations

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12 December 2020

Evidence for involvement of polymorphic CYP2C19 and 2C9 in the N-demethylation of sertraline in human liver microsomes

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12 December 2020

Identification of human cytochrome p450 isozymes involved in diphenhydramine N-demethylation.

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12 December 2020

Dihydrocodeine: a new opioid substrate for the polymorphic CYP2D6 in humans

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12 December 2020

Cytochrome P4502D6 catalyzes the O-demethylation of the psychoactive alkaloid ibogaine to 12-hydroxyibogamine.

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12 December 2020

Influence of enzyme induction and inhibition on the oxidation of nifedipine, sparteine, mephenytoin and antipyrine in humans as assessed by a "cocktail" study design

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12 December 2020

Use of a propafenone metabolic ratio as a measure of CYP2D6 activity

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12 December 2020

The genetic polymorphism of sparteine metabolism

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12 December 2020

Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.

1 reference

12 December 2020

Influence of debrisoquin phenotype on the inducibility of propranolol metabolism

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12 December 2020

Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles

1 reference

12 December 2020

Metabolism of epinastine, a histamine H1 receptor antagonist, in human liver microsomes in comparison with that of terfenadine

1 reference

12 December 2020

Systemic adverse effects of beta-adrenergic blockers: an evidence-based assessment

1 reference

12 December 2020

Almotriptan, a new anti-migraine agent: a review.

1 reference

12 December 2020

O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants

1 reference

12 December 2020

Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes

1 reference

12 December 2020

Nomenclature for human CYP2D6 alleles.

1 reference

12 December 2020

CYP2B6, CYP2D6, and CYP3A4 catalyze the primary oxidative metabolism of perhexiline enantiomers by human liver microsomes

1 reference

12 December 2020

Minimal effective concentration values of propafenone and 5-hydroxy-propafenone in acute and chronic therapy.

1 reference

12 December 2020

Co-inheritance of the polymorphic metabolism of encainide and debrisoquin

1 reference

12 December 2020

Influence of CYP2C9, 2C19 and 2D6 genetic polymorphisms on the steady-state plasma concentrations of the enantiomers of fluoxetine and norfluoxetine

1 reference

12 December 2020

Duloxetine is both an inhibitor and a substrate of cytochrome P4502D6 in healthy volunteers

1 reference

12 December 2020

Evidence for altered catalytic properties of the cytochrome P-450 involved in sparteine oxidation in poor metabolizers

1 reference

12 December 2020

Genetic polymorphism of CYP2D6 in North Indian subjects

1 reference

12 December 2020

Polymorphism of propafenone metabolism and disposition in man: clinical and pharmacokinetic consequences

1 reference

12 December 2020

New allelic arrangement CYP2D6*36 x 2 found in a Japanese poor metabolizer of debrisoquine

1 reference

12 December 2020

A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine

1 reference

12 December 2020

Frequent occurrence of CYP2D6 gene duplication in Saudi Arabians

1 reference

12 December 2020

Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450

1 reference

12 December 2020

Effect of CYP2D6 genotype on flecainide pharmacokinetics in Japanese patients with supraventricular tachyarrhythmia.

1 reference

12 December 2020

Mechanism of cytochrome P450 2D6-catalyzed sparteine metabolism in humans

1 reference

12 December 2020

Metoprolol metabolism via cytochrome P4502D6 in ethnic populations

1 reference

12 December 2020

Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes

1 reference

12 December 2020

Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism

1 reference

12 December 2020

Functional properties of CYP2D6 1 (wild-type) and CYP2D6 7 (His324Pro) expressed by recombinant baculovirus in insect cells

1 reference

12 December 2020

Stereoselective disposition of mianserin is related to debrisoquin hydroxylation polymorphism

1 reference

12 December 2020

Paroxetine affects metoprolol pharmacokinetics and pharmacodynamics in healthy volunteers

1 reference

12 December 2020

10-Hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes

1 reference

12 December 2020

(R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes

1 reference

12 December 2020

Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers

1 reference

12 December 2020

A novel intronic mutation, 2988G>A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects.

1 reference

12 December 2020

A long PCR assay to distinguish CYP2D6*5 and a novel CYP2D6 mutant allele associated with an 11-kb EcoRI haplotype.

1 reference

12 December 2020

Analysis of the CYP2D6 gene mutations and their consequences for enzyme function in a West African population

1 reference

12 December 2020

Polymorphic hydroxylation of perhexiline maleate in man.

1 reference

12 December 2020

Phenotypes and genotypes for CYP2D6 and CYP2C19 in a black Tanzanian population.

1 reference

12 December 2020

Relative contribution of CYP3A to amitriptyline clearance in humans: in vitro and in vivo studies

1 reference

12 December 2020

Polymorphic ability to metabolize propranolol alters 4-hydroxypropranolol levels but not beta blockade

1 reference

12 December 2020

The effect of fluoxetine on the pharmacokinetics and safety of risperidone in psychotic patients

1 reference

12 December 2020

Molecular basis of genetic variation in debrisoquin hydroxylation in Chinese subjects: polymorphism in RFLP and DNA sequence of CYP2D6

1 reference

12 December 2020

Expression and functional analysis of CYP2D6.24, CYP2D6.26, CYP2D6.27, and CYP2D7 isozymes

1 reference

12 December 2020

Raised serum levels of desipramine with the antiarrhythmic propafenone

1 reference

12 December 2020

The disposition of fluoxetine but not sertraline is altered in poor metabolizers of debrisoquin

1 reference

12 December 2020

Human cytochromes mediating gepirone biotransformation at low substrate concentrations

1 reference

12 December 2020

Detection of the poor metabolizer-associated CYP2D6(D) gene deletion allele by long-PCR technology

1 reference

12 December 2020

Polymorphic dextromethorphan metabolism: co-segregation of oxidative O-demethylation with debrisoquin hydroxylation

1 reference

12 December 2020

Crystal structure of human cytochrome P450 2D6

1 reference

12 December 2020

Pharmacokinetics of metoprolol enantiomers in Chinese subjects of major CYP2D6 genotypes

1 reference

12 December 2020

Studies on the Stereoselective Metabolism of Citalopram by Human Liver Microsomes and cDNA-Expressed Cytochrome P450 Enzymes

1 reference

12 December 2020

Concentration dependent stereoselectivity of propafenone N-depropylation metabolism with human hepatic recombinant CYP1A2

1 reference

12 December 2020

The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen

1 reference

12 December 2020

Substrate specific metabolism by polymorphic cytochrome P450 2D6 alleles

1 reference

12 December 2020

Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.

1 reference

12 December 2020

CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure

1 reference

12 December 2020

A new CYP2D6 allele with a nine base insertion in exon 9 in a Japanese population associated with poor metabolizer phenotype

1 reference

12 December 2020

Impaired oxidation of debrisoquine in patients with perhexiline neuropathy

1 reference

12 December 2020

Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes

1 reference

12 December 2020

Effect of low dose quinidine on encainide pharmacokinetics and pharmacodynamics. Influence of genetic polymorphism.

1 reference

12 December 2020

Relationship between the CYP2D6 genotype and the steady-state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine

1 reference

12 December 2020

Use of quinidine inhibition to define the role of the sparteine/debrisoquine cytochrome P450 in metoprolol oxidation by human liver microsomes

1 reference

12 December 2020

Stereoselective hydroxylation of mexiletine in human liver microsomes: implication of P450IID6--a preliminary report

1 reference

12 December 2020

Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.

1 reference

12 December 2020

Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences

1 reference

12 December 2020

Influence of the defective metabolism of sparteine on its pharmacokinetics

1 reference

12 December 2020

Effect of ketoconazole on venlafaxine plasma concentrations in extensive and poor metabolisers of debrisoquine

1 reference

12 December 2020

Influence of debrisoquine phenotype and of quinidine on mexiletine disposition in man.

1 reference

12 December 2020

Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry

1 reference

12 December 2020

Homologous unequal cross-over involving a 2.8 kb direct repeat as a mechanism for the generation of allelic variants of human cytochrome P450 CYP2D6 gene.

1 reference

12 December 2020

Demethylation and hydroxylation of amitriptyline, nortriptyline, and 10-hydroxyamitriptyline in human liver microsomes

1 reference

12 December 2020

Pharmacogenetics, drug-metabolizing enzymes, and clinical practice

1 reference

12 December 2020

Different effects of inhibitors on the O- and N-demethylation of codeine in human liver microsomes

1 reference

12 December 2020

Topical ophthalmic beta-adrenergic blockade for the treatment of glaucoma and ocular hypertension

1 reference

12 December 2020

Frequencies of CYP2D6 mutant alleles in a normal Japanese population and metabolic activity of dextromethorphan O-demethylation in different CYP2D6 genotypes

1 reference

12 December 2020

The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6.

1 reference

12 December 2020

Oxidative metabolism of zolpidem by human liver cytochrome P450S

1 reference

12 December 2020

Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study

1 reference

12 December 2020

CYP2D6 genotype in relation to perphenazine concentration and pituitary pharmacodynamic tissue sensitivity in Asians: CYP2D6-serotonin-dopamine crosstalk revisited.

1 reference

12 December 2020

Sequence-based analysis of the CYP2D6*36-CYP2D6*10 tandem-type arrangement, a major CYP2D6*10 haplotype in the Japanese population.

1 reference

12 December 2020

Pharmacokinetic and pharmacodynamic interaction between mexiletine and propafenone in human beings

1 reference

12 December 2020

Influence of genetic polymorphism on the metabolism and disposition of encainide in man

1 reference

12 December 2020

Propranolol disposition in Chinese subjects of different CYP2D6 genotypes

1 reference

12 December 2020

Polymorphic flecainide disposition under conditions of uncontrolled urine flow and pH

1 reference

12 December 2020

Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes.

1 reference

12 December 2020

Clinical pharmacology of tramadol

1 reference

12 December 2020

Is perhexiline essential for the optimal management of angina pectoris?

1 reference

12 December 2020

Summary of information on human CYP enzymes: human P450 metabolism data

1 reference

12 December 2020

Disposition kinetics of encainide and metabolites

1 reference

12 December 2020

Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17

1 reference

12 December 2020

Influence of CYP2D6 activity on the disposition and cardiovascular toxicity of the antidepressant agent venlafaxine in humans

1 reference

12 December 2020

Vernakalant: pharmacology electrophysiology, safety and efficacy

1 reference

12 December 2020

Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine

1 reference

12 December 2020

Pharmacokinetics and electrocardiographic effects of a new controlled-release form of flecainide acetate: comparison with the standard form and influence of the CYP2D6 polymorphism

1 reference

12 December 2020

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants

1 reference

12 December 2020

Debrisoquine and metoprolol oxidation in Zambians: a population study

1 reference

12 December 2020

Cytochrome P450 enzymes contributing to demethylation of maprotiline in man.

1 reference

12 December 2020

Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen.

1 reference

12 December 2020

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

1 reference

12 December 2020

Occurrence of CYP2D6 gene duplication in Hong Kong Chinese

1 reference

12 December 2020

Ophthalmic timolol: plasma concentration and systemic cardiopulmonary effects.

1 reference

12 December 2020

A study of genetic (CYP2D6 and ABCB1) and environmental (drug inhibitors and inducers) variables that may influence plasma risperidone levels.

1 reference

12 December 2020

Influence of Cyp2D6 Genetic Polymorphism on Ratios of Steady-state Serum Concentration to Dose of the Neuroleptic Zuclopenthixol

1 reference

12 December 2020

Impaired expression of CYP2D6 in intermediate metabolizers carrying the *41 allele caused by the intronic SNP 2988G>A: evidence for modulation of splicing events.

1 reference

12 December 2020

Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives

1 reference

12 December 2020

The utility of serum drug level monitoring during therapy with class III antiarrhythmic agents

1 reference

12 December 2020

Role of polymorphic debrisoquin 4-hydroxylase activity in the stereoselective disposition of mexiletine in humans

1 reference

12 December 2020

Imipramine demethylation and hydroxylation: impact of the sparteine oxidation phenotype

1 reference

12 December 2020

CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants

1 reference

12 December 2020

Pharmacogenetic determination of the effects of codeine and prediction of drug interactions

1 reference

12 December 2020

Encainide and its metabolites. Comparative effects in man on ventricular arrhythmia and electrocardiographic intervals

1 reference

12 December 2020

Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population

1 reference

12 December 2020

Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects

1 reference

12 December 2020

Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population

1 reference

12 December 2020

CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxine

1 reference

12 December 2020

Paroxetine potentiates the central nervous system side effects of perphenazine: contribution of cytochrome P4502D6 inhibition in vivo.

1 reference

12 December 2020

Almotriptan: an effective and well-tolerated treatment for migraine pain.

1 reference

12 December 2020

Stereoselective disposition of carvedilol in man after intravenous and oral administration of the racemic compound

1 reference

12 December 2020

The CYP2D6 genotype and plasma concentrations of mianserin enantiomers in relation to therapeutic response to mianserin in depressed Japanese patients

1 reference

12 December 2020

Metabolism of the antidepressant mirtazapine in vitro: contribution of cytochromes P-450 1A2, 2D6, and 3A4

1 reference

12 December 2020

1- and 3-hydroxylations, in addition to 4-hydroxylation, of debrisoquine are catalyzed by cytochrome P450 2D6 in humans

1 reference

12 December 2020

In vitro identification of the human cytochrome P-450 enzymes involved in the N-demethylation of azelastine.

1 reference

12 December 2020

Decreased capacity for debrisoquine metabolism among black Tanzanians: analyses of the CYP2D6 genotype and phenotype

1 reference

12 December 2020

Serum Concentrations and Side Effects in Psychiatric Patients During Risperidone Therapy

1 reference

12 December 2020

Localization of the CYP2D gene locus to human chromosome 22q13.1 by polymerase chain reaction, in situ hybridization, and linkage analysis

1 reference

12 December 2020

Comparative evolutionary pharmacogenetics of CYP2D6 in Ngawbe and Embera Amerindians of Panama and Colombia: role of selection versus drift in world populations

1 reference

12 December 2020

Stereospecific pharmacokinetics and pharmacodynamics of beta-adrenergic blockers in humans

1 reference

12 December 2020

Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population

1 reference

12 December 2020

Characterization of the human cytochrome P450 enzymes involved in the metabolism of dihydrocodeine

1 reference

12 December 2020

A review of the pharmacological and clinical profile of mirtazapine

1 reference

12 December 2020

Identification and characterization of the cytochrome P450 enzymes involved in N-dealkylation of propafenone: molecular base for interaction potential and variable disposition of active metabolites

1 reference

12 December 2020

Impact of stereoselectivity on the pharmacokinetics and pharmacodynamics of antiarrhythmic drugs

1 reference

12 December 2020

Metoprolol-paroxetine interaction in human liver microsomes: stereoselective aspects and prediction of the in vivo interaction.

1 reference

12 December 2020

Substrate specificity, inhibitors and regulation of human cytochrome P450 2D6 and implications in drug development

1 reference

12 December 2020

Patient-tailored antiemetic treatment with 5-hydroxytryptamine type 3 receptor antagonists according to cytochrome P-450 2D6 genotypes

1 reference

12 December 2020

Metabolic ratios of psychotropics as indication of cytochrome P450 2D6/2C19 genotype

1 reference

12 December 2020

Inhibitory effects of H1-antihistamines on CYP2D6- and CYP2C9-mediated drug metabolic reactions in human liver microsomes

1 reference

12 December 2020

Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans

1 reference

12 December 2020

The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19.

1 reference

12 December 2020

CYP2D6 catalyzes tamoxifen 4-hydroxylation in human liver

1 reference

12 December 2020

Atypical metabolism of deprenyl and its enantiomer, (S)-(+)-N,alpha-dimethyl-N-propynylphenethylamine, by cytochrome P450 2D6.

1 reference

12 December 2020

Pharmacokinetic profile of encainide.

1 reference

12 December 2020

The oxidative metabolism of metoprolol in human liver microsomes: inhibition by the selective serotonin reuptake inhibitors.

1 reference

12 December 2020

Cytochrome P-450 isoforms involved in carboxylic acid ester cleavage of Hantzsch pyridine ester of pranidipine

1 reference

12 December 2020

The 2988G>A polymorphism affects splicing of a CYP2D6 minigene.

1 reference

12 December 2020

The role of CYP2C19 in the metabolism of (+/-) bufuralol, the prototypic substrate of CYP2D6

1 reference

12 December 2020

Single-dose quinidine treatment inhibits mexiletine oxidation in extensive metabolizers of debrisoquine

1 reference

12 December 2020

Debrisoquin hydroxylation polymorphism among Ghanaians and Caucasians

1 reference

12 December 2020

Propranolol's metabolism is determined by both mephenytoin and debrisoquin hydroxylase activities

1 reference

12 December 2020

Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance

1 reference

12 December 2020

The CYP2D6 genotype predicts the oral clearance of the neuroleptic agents perphenazine and zuclopenthixol.

1 reference

12 December 2020

Studies on the metabolism of perhexiline in man.

1 reference

12 December 2020

Metoprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects: Japanese versus mainland Chinese

1 reference

12 December 2020

Elucidation of the genetic basis of the common 'intermediate metabolizer' phenotype for drug oxidation by CYP2D6

1 reference

12 December 2020

Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings

1 reference

12 December 2020

CYP2D6 genotypes in a Japanese population: low frequencies of CYP2D6 gene duplication but high frequency of CYP2D6*10

1 reference

12 December 2020

The polymorphic cytochrome P-4502D6 is involved in the metabolism of both 5-hydroxytryptamine antagonists, tropisetron and ondansetron

1 reference

12 December 2020

In vitro characterization of cytochrome P450 catalysed metabolism of the antiemetic tropisetron

1 reference

12 December 2020

Interaction between propranolol and propafenone in healthy volunteers

1 reference

12 December 2020

Pharmacogenetic variation at CYP2C9, CYP2C19, and CYP2D6 at global and microgeographic scales

1 reference

12 December 2020

Catalytic specificity of CYP2D isoforms in rat and human

1 reference

12 December 2020

Frequent occurrence of CYP2D6*10 duplication allele in a Japanese population

1 reference

12 December 2020

Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine. Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6.

1 reference

12 December 2020

Mexiletine kinetics in healthy subjects taking cimetidine

1 reference

12 December 2020

Prospective cytochrome P450 phenotyping for neuroleptic treatment in dementia.

1 reference

12 December 2020

Ten percent of North Spanish individuals carry duplicated or triplicated CYP2D6 genes associated with ultrarapid metabolism of debrisoquine

1 reference

12 December 2020

Significant interaction between the nonprescription antihistamine diphenhydramine and the CYP2D6 substrate metoprolol in healthy men with high or low CYP2D6 activity

1 reference

12 December 2020

Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes

1 reference

12 December 2020

Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism.

1 reference

12 December 2020

Proceedings: N-oxidation of sparteine in man and its interindividual differences

1 reference

12 December 2020

Cytochrome P450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylase

1 reference

12 December 2020

Consequences of rifampicin treatment on propafenone disposition in extensive and poor metabolizers of CYP2D6

1 reference

12 December 2020

Characterization and PCR-based detection of two different hybrid CYP2D7P/CYP2D6 alleles associated with the poor metabolizer phenotype

1 reference

12 December 2020

Vernakalant hydrochloride for rapid conversion of atrial fibrillation: a phase 3, randomized, placebo-controlled trial

1 reference

12 December 2020

Systemic adverse effects of ophthalmic beta-blockers

1 reference

12 December 2020

Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer

1 reference

12 December 2020

Pharmacogenetic study of the response to flecainide and propafenone in patients with atrial fibrillation

1 reference

12 December 2020

The biotransformation of clomipramine in vitro, identification of the cytochrome P450s responsible for the separate metabolic pathways

1 reference

12 December 2020

Regioselective and stereoselective oxidation of metoprolol and bufuralol catalyzed by microsomes containing cDNA-expressed human P4502D6.

1 reference

12 December 2020

Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis

1 reference

12 December 2020

Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions

1 reference

12 December 2020

Involvement of CYP2D6 but not CYP2C19 in nicergoline metabolism in humans

1 reference

12 December 2020

Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication.

1 reference

12 December 2020

CYP2D6 genotype and phenotyping by determination of dextromethorphan and metabolites in serum of healthy controls and of patients under psychotropic medication.

1 reference

12 December 2020

Lack of pharmacokinetic interaction between mexiletine and omeprazole

1 reference

12 December 2020

Polymorphic hydroxylation of perhexiline in vitro

1 reference

12 December 2020

Evolution of a highly polymorphic human cytochrome P450 gene cluster: CYP2D6.

1 reference

12 December 2020

Genetic analysis of the interethnic difference between Chinese and Caucasians in the polymorphic metabolism of debrisoquine and codeine

1 reference

12 December 2020

Pharmacokinetic and pharmacodynamic evaluation of propafenone in patients with ventricular arrhythmia. Propafenone Research Group

1 reference

12 December 2020

CYP3A is responsible for N-dealkylation of haloperidol and bromperidol and oxidation of their reduced forms by human liver microsomes

1 reference

12 December 2020

Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity

1 reference

12 December 2020

Identification of human cytochrome P450 isoforms involved in the 7-hydroxylation of chlorpromazine by human liver microsomes

1 reference

12 December 2020

A rare G2061 insertion affecting the open reading frame of CYP2D6 and responsible for the poor metabolizer phenotype

1 reference

12 December 2020

Steady-state plasma levels of nortriptyline and its hydroxylated metabolites in Japanese patients: impact of CYP2D6 genotype on the hydroxylation of nortriptyline

1 reference

12 December 2020

Lack of a kinetic interaction between fluconazole and mexiletine

1 reference

12 December 2020

Pharmacogenetics of cytochrome p4502D6: genetic background and clinical implication

1 reference

12 December 2020

Cytochrome P450 2D6 genotype and steady state plasma levels of risperidone and 9-hydroxyrisperidone

1 reference

12 December 2020

CYP2D6 genotype and venlafaxine-XR concentrations in depressed elderly

1 reference

12 December 2020

Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)- and (S)-methadone in vitro

1 reference

12 December 2020

Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57).

1 reference

12 December 2020

A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.

1 reference

12 December 2020

Identification of human liver cytochrome P450s involved in the microsomal metabolism of the antihistaminic drug loratadine

1 reference

12 December 2020

Interindividual variation of beta-adrenoceptor blocking drugs, plasma concentration and effect: influence of genetic status on behaviour of atenolol, bopindolol and metoprolol

1 reference

12 December 2020

Risperidone metabolism in relation to CYP2D6*10 allele in Korean schizophrenic patients

1 reference

12 December 2020

The metabolic fate of 2H-labelled propafenone in man

1 reference

12 December 2020

Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver

1 reference

12 December 2020

The roles of CYP2D6 and stereoselectivity in the clinical pharmacokinetics of chlorpheniramine

1 reference

12 December 2020

CYP2D6 is the principal cytochrome P450 responsible for metabolism of the histamine H1 antagonist promethazine in human liver microsomes

1 reference

12 December 2020

Polymorphism in the CYP2D6 Tamoxifen-Metabolizing Gene Influences Clinical Effect but Not Hot Flashes: Data From the Italian Tamoxifen Trial

1 reference

12 December 2020

CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment

1 reference

12 December 2020

Fluoxetine impairs the CYP2D6-mediated metabolism of propafenone enantiomers in healthy Chinese volunteers

1 reference

12 December 2020

Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.

1 reference

12 December 2020

Azelastine N-demethylation by cytochrome P-450 (CYP)3A4, CYP2D6, and CYP1A2 in human liver microsomes: evaluation of approach to predict the contribution of multiple CYPs

1 reference

12 December 2020

The hypoalgesic effect of tramadol in relation to CYP2D6*

1 reference

12 December 2020

Tolterodine, a new muscarinic receptor antagonist, is metabolized by cytochromes P450 2D6 and 3A in human liver microsomes

1 reference

12 December 2020

Biphasic kinetics of quaternary ammonium glucuronide formation from amitriptyline and diphenhydramine in human liver microsomes.

1 reference

12 December 2020

Metabolism of metoprolol-(3-h) in man, the dog and the rat

1 reference

12 December 2020

Oxidative metabolism of encainide: polymorphism, pharmacokinetics and clinical considerations

1 reference

12 December 2020

Impact of the CYP2D6 ultrarapid metabolizer genotype on mirtazapine pharmacokinetics and adverse events in healthy volunteers

1 reference

12 December 2020

Interaction of terfenadine and its primary metabolites with cytochrome P450 2D6

1 reference

12 December 2020

Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6.

1 reference

12 December 2020

Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans

1 reference

12 December 2020

The influence of CYP2D6 polymorphism on the antiarrhythmic efficacy of propafenone in patients with paroxysmal atrial fibrillation during 3 months propafenone prophylactic treatment.

1 reference

12 December 2020

Different enantioselective 9-hydroxylation of risperidone by the two human CYP2D6 and CYP3A4 enzymes.

1 reference

12 December 2020

Metabolism of delavirdine, a human immunodeficiency virus type-1 reverse transcriptase inhibitor, by microsomal cytochrome P450 in humans, rats, and other species: probable involvement of CYP2D6 and CYP3A.

1 reference

12 December 2020

Characterization of human cytochrome p450 enzymes involved in the metabolism of the piperidine-type phenothiazine neuroleptic thioridazine

1 reference

12 December 2020

Oral flecainide acetate for the treatment of ventricular arrhythmias

1 reference

12 December 2020

Ultrarapid metabolism of sparteine: frequency of alleles with duplicated CYP2D6 genes in a Danish population as determined by restriction fragment length polymorphism and long polymerase chain reaction.

1 reference

12 December 2020

Debrisoquine polymorphism and the metabolism and action of metoprolol, timolol, propranolol and atenolol

1 reference

12 December 2020

Inhibitory studies of mexiletine and dextromethorphan oxidation in human liver microsomes

1 reference

12 December 2020

Identification of human p450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its inhibitory effect on enzyme activity

1 reference

12 December 2020

Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A.

1 reference

12 December 2020

The relationship between paroxetine and the sparteine oxidation polymorphism

1 reference

12 December 2020

Genetic polymorphism of CYP2D6 and lung cancer risk in African-Americans and Caucasians in Los Angeles County

1 reference

12 December 2020

Identification of cytochrome P450 enzymes involved in the metabolism of zotepine, an antipsychotic drug, in human liver microsomes

1 reference

12 December 2020

Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors

1 reference

12 December 2020

Polymorphism of human cytochrome P450 enzymes and its clinical impact

1 reference

12 December 2020

Venlafaxine. A review of its pharmacology and therapeutic potential in depression

1 reference

12 December 2020

Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events.

1 reference

12 December 2020

Polymorphic hydroxylation of Debrisoquine in man.

1 reference

12 December 2020

Identification of human P450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its kinetic parameters and inhibition constants

1 reference

12 December 2020

Evidence for environmental influence on CYP2D6-catalysed debrisoquine hydroxylation as demonstrated by phenotyping and genotyping of Ethiopians living in Ethiopia or in Sweden

1 reference

12 December 2020

Escitalopram (S-citalopram) and its metabolites in vitro: cytochromes mediating biotransformation, inhibitory effects, and comparison to R-citalopram

1 reference

12 December 2020

A combination of mutations in the CYP2D6*17 (CYP2D6Z) allele causes alterations in enzyme function.

1 reference

12 December 2020

Steady-state serum concentrations of the neuroleptic perphenazine in relation to CYP2D6 genetic polymorphism

1 reference

12 December 2020

Genetic variation in the CYP2D6 gene is associated with a lower heart rate and blood pressure in beta-blocker users

1 reference

12 December 2020

Chlorpheniramine plasma concentration and histamine H1-receptor occupancy.

1 reference

12 December 2020

Phenotype and genotype analysis of debrisoquine hydroxylase (CYP2D6) in a black Zimbabwean population. Reduced enzyme activity and evaluation of metabolic correlation of CYP2D6 probe drugs

1 reference

12 December 2020

The influence of CYP2D6 activity on the kinetics of propafenone enantiomers in Chinese subjects

1 reference

12 December 2020

Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of dolasetron. Comparison with other indole-containing 5-HT3 antagonists

1 reference

12 December 2020

Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution.

1 reference

12 December 2020

Quinidine reduces clearance of (+)-propranolol more than (-)-propranolol through marked reduction in 4-hydroxylation

1 reference

12 December 2020

CYP2D6 phenotype-genotype relationships in African-Americans and Caucasians in Los Angeles.

1 reference

12 December 2020

Antiarrhythmic activity, electrocardiographic effects and pharmacokinetics of the encainide metabolites O-desmethyl encainide and 3-methoxy-O-desmethyl encainide in man

1 reference

12 December 2020

CYP2B6 and CYP2C19 as the major enzymes responsible for the metabolism of selegiline, a drug used in the treatment of Parkinson's disease, as revealed from experiments with recombinant enzymes

1 reference

12 December 2020

Carvedilol: a review of its use in chronic heart failure

1 reference

12 December 2020

Impaired oxidation of debrisoquine in patients with perhexiline liver injury

1 reference

12 December 2020

Identification of the human cytochrome P450 isoforms mediating in vitro N-dealkylation of perphenazine

1 reference

12 December 2020

Clinical importance of the cytochromes P450

1 reference

12 December 2020

Involvement of CYP2D6 in oxidative metabolism of cinnarizine and flunarizine in human liver microsomes

1 reference

12 December 2020

Biotransformation and elimination of 14C-flecainide acetate in humans

1 reference

12 December 2020

Identification of three cytochrome P450 isozymes involved in N-demethylation of citalopram enantiomers in human liver microsomes.

1 reference

12 December 2020

Carvedilol. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy

1 reference

12 December 2020

Identification of the human cytochromes P450 responsible for atomoxetine metabolism

1 reference

12 December 2020

Single-step assays to analyze CYP2D6 gene polymorphisms in Asians: allele frequencies and a novel *14B allele in mainland Chinese

1 reference

12 December 2020

Variable disposition kinetics and electrocardiographic effects of flecainide during repeated dosing in humans: contribution of genetic factors, dose-dependent clearance, and interaction with amiodarone

1 reference

12 December 2020

Propafenone in a usual dose produces severe side-effects: the impact of genetically determined metabolic status on drug therapy

1 reference

12 December 2020

CYP2D6 genetic variation in healthy adults and psychiatric African-American subjects: implications for clinical practice and genetic testing

1 reference

12 December 2020

The metabolism of tramadol by human liver microsomes

1 reference

12 December 2020

Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population

1 reference

12 December 2020

In vitro identification of the human cytochrome P450 enzymes involved in the metabolism of R(+)- and S(-)-carvedilol

1 reference

12 December 2020

Importance of the proline-rich region following signal-anchor sequence in the formation of correct conformation of microsomal cytochrome P-450s

1 reference

12 December 2020

Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs

1 reference

12 December 2020

Coordinated intrahepatic and extrahepatic regulation of cytochrome p4502D6 in healthy subjects and in patients after liver transplantation

1 reference

12 December 2020

The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene

1 reference

12 December 2020

Pharmacokinetic interaction of flecainide and paroxetine in relation to the CYP2D6*10 allele in healthy Korean subjects

1 reference

12 December 2020

Lack of interaction between amiodarone and mexiletine in cardiac arrhythmia patients

1 reference

12 December 2020

Venlafaxine oxidation in vitro is catalysed by CYP2D6.

1 reference

12 December 2020

Identification of cytochrome P450 isoforms involved in citalopram N-demethylation by human liver microsomes

1 reference

12 December 2020

Enantiomer/enantiomer interaction of (S)- and (R)-propafenone for cytochrome P450IID6-catalyzed 5-hydroxylation: in vitro evaluation of the mechanism

1 reference

12 December 2020

Pharmacokinetics of the antianginal agent perhexiline: relationship between metabolic ratio and steady-state dose

1 reference

12 December 2020

Inhibition by paroxetine of desipramine metabolism in extensive but not in poor metabolizers of sparteine

1 reference

12 December 2020

Kinetics of oral and intravenous mexiletine: lack of effect of cimetidine and ranitidine

1 reference

12 December 2020

The identification and analysis of mexiletine and its metabolic products in man

1 reference

12 December 2020

Almotriptan: a review of its use in migraine

1 reference

12 December 2020

Inhibition of the enantioselective oxidative metabolism of metoprolol by verapamil in human liver microsomes

1 reference

12 December 2020

CYP2D7 splice variants in human liver and brain: does CYP2D7 encode functional protein?

1 reference

12 December 2020

Influence of CYP2D6*10B genotype on pharmacokinetics of propafenone enantiomers in Chinese subjects

1 reference

12 December 2020

Impact of CYP2D6 genotype on adverse effects during treatment with metoprolol: a prospective clinical study

1 reference

12 December 2020

Clinical pharmacokinetics of encainide

1 reference

12 December 2020

Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine

1 reference

12 December 2020

Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine

1 reference

12 December 2020

DNA haplotype-dependent differences in the amino acid sequence of debrisoquine 4-hydroxylase (CYP2D6): evidence for two major allozymes in extensive metabolisers

1 reference

12 December 2020

Plasma levels of thioridazine and metabolites are influenced by the debrisoquin hydroxylation phenotype

1 reference

12 December 2020

Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes

1 reference

12 December 2020

Microsomal binding of amitriptyline: effect on estimation of enzyme kinetic parameters in vitro.

1 reference

12 December 2020

Five distinct human cytochromes mediate amitriptyline N-demethylation in vitro: dominance of CYP 2C19 and 3A4

1 reference

12 December 2020

Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes

1 reference

12 December 2020

The decreased in vivo clearance of CYP2D6 substrates by CYP2D6*10 might be caused not only by the low-expression but also by low affinity of CYP2D6.

1 reference

12 December 2020

Limited association of the 2988g > a single nucleotide polymorphism with CYP2D641 in black subjects

1 reference

12 December 2020

New cytochrome P450 2D6*56 allele identified by genotype/phenotype analysis of cryopreserved human hepatocytes.

1 reference

12 December 2020

Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes

1 reference

12 December 2020

Steady-state plasma levels of clomipramine and its metabolites: impact of the sparteine/debrisoquine oxidation polymorphism. Danish University Antidepressant Group.

1 reference

12 December 2020

CYP2D6 is a major determinant of metoprolol disposition and effects in hospitalized Russian patients treated for acute myocardial infarction

1 reference

12 December 2020

Enantiospecific pharmacokinetics of metoprolol in CYP2D6 ultra-rapid metabolizers and correlation with exercise-induced heart rate

1 reference

12 December 2020

Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes

1 reference

12 December 2020

Effects of the CYP2D6 gene duplication on the pharmacokinetics and pharmacodynamics of tramadol

1 reference

12 December 2020

Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes

1 reference

12 December 2020

CYP2D6 polymorphisms and the impact on tamoxifen therapy

1 reference

12 December 2020

A novel CYP2D6 allele with an abolished splice recognition site associated with the poor metabolizer phenotype

1 reference

12 December 2020

The major fluvoxamine metabolite in urine is formed by CYP2D6.

1 reference

12 December 2020

Neuroleptic dosage for Asians

1 reference

12 December 2020

A natural variant of the heme-binding signature (R441C) resulting in complete loss of function of CYP2D6

1 reference

12 December 2020

Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism

1 reference

12 December 2020

Disposition of the neuroleptic zuclopenthixol cosegregates with the polymorphic hydroxylation of debrisoquine in humans

1 reference

12 December 2020

Propafenone. A reappraisal of its pharmacology, pharmacokinetics and therapeutic use in cardiac arrhythmias

1 reference

12 December 2020

G169R mutation diminishes the metabolic activity of CYP2D6 in Chinese

1 reference

12 December 2020

Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation

1 reference

12 December 2020

Timolol: a review of its therapeutic efficacy in the topical treatment of glaucoma

1 reference

12 December 2020

Systemic absorption of ocular timolol in poor and extensive metabolizers of debrisoquine

1 reference

12 December 2020

Steady-state plasma levels of nortriptyline in twins: influence of genetic factors and drug therapy

1 reference

12 December 2020

Use of electrospray ionization liquid chromatography-mass spectrometry to study the role of CYP2D6 in the in vitro metabolism of 5-hydroxytryptamine receptor antagonists

1 reference

12 December 2020

Stereoselective metabolism of bufuralol racemate and enantiomers in human liver microsomes

1 reference

12 December 2020

Concentrations of tramadol and O-desmethyltramadol enantiomers in different CYP2D6 genotypes

1 reference

12 December 2020

A bioinformatics approach for the phenotype prediction of nonsynonymous single nucleotide polymorphisms in human cytochromes P450.

1 reference

12 December 2020

The clinical role of genetic polymorphisms in drug-metabolizing enzymes

1 reference

12 December 2020

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine

1 reference

12 December 2020

An additional allelic variant of the CYP2D6 gene causing impaired metabolism of sparteine

1 reference

12 December 2020

Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2

1 reference

12 December 2020

The impact of the CYP2D6 and CYP2C19 genotypes on venlafaxine pharmacokinetics in a Japanese population

1 reference

12 December 2020

Polymorphism of dextromethorphan metabolism: relationships between phenotype, genotype and response to the administration of encainide in humans

1 reference

12 December 2020

Pharmacogenetic explanation for excessive beta-blockade following timolol eye drops. Potential for oral-ophthalmic drug interaction

1 reference

12 December 2020

Sparteine metabolism capacity in human liver: structural variants of human P450IID6 as assessed by immunochemistry

1 reference

12 December 2020

A PET study of D2 and 5-HT2 receptor occupancy induced by risperidone in poor metabolizers of debrisoquin and risperidone

1 reference

12 December 2020

Correlation of CYP2D6 genotype with perhexiline phenotypic metabolizer status

1 reference

12 December 2020

Clinical pharmacogenetics and potential application in personalized medicine

1 reference

12 December 2020

The role of genetically determined polymorphic drug metabolism in the beta-blockade produced by propafenone

1 reference

12 December 2020

Mexiletine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in the treatment of arrhythmias

1 reference

12 December 2020

Regioisomeric aromatic dihydroxylation of propranolol. Synthesis and identification of 4,6- and 4,8-dihydroxypropranolol as metabolites in the rat and in man

1 reference

12 December 2020

The O-demethylation of the antidementia drug galanthamine is catalysed by cytochrome P450 2D6

1 reference

12 December 2020

Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine

1 reference

12 December 2020

Differences in the inhibitory effect of cimetidine on desipramine metabolism between rapid and slow debrisoquin hydroxylators

1 reference

12 December 2020

Polymorphic CYP2D6 mediates O-demethylation of the opioid analgesic tramadol

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Influence of CYP2D6 polymorphism on the pharmacokinetics and pharmacodynamic of tolterodine.

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12 December 2020

10.2165/11318030-000000000-00000

Identifiers

DOI

1 reference

PubMed ID

19817501

Dimensions Publication ID

21 August 2017

0 references

1 reference

PubMed ID

19817501