Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives (Q35941387)

11 August 2017

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title

Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives (English)

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11 August 2017

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Carsten Skarke

2

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Jörn Lötsch

object named as

Jörn Lötsch

series ordinal

1

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author name string

Jürgen Liefhold

series ordinal

3

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PubMed ID

15530129

11 August 2017

Gerd Geisslinger

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4

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11 August 2017

1 January 2004

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Clinical Pharmacokinetics

11 August 2017

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11 August 2017

43

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11 August 2017

14

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11 August 2017

983-1013

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https://scigraph.springernature.com/pub.10.2165/00003088-200443140-00003

11 August 2017

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cites work

The genetic mediation of individual differences in sensitivity to pain and its inhibition

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12 December 2020

Ondansetron inhibits the analgesic effects of tramadol: a possible 5-HT(3) spinal receptor involvement in acute pain in humans

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12 December 2020

Pharmacokinetics of codeine and its metabolites in Caucasian healthy volunteers: comparisons between extensive and poor hydroxylators of debrisoquine

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12 December 2020

The human delta-opioid receptor: genomic organization, cDNA cloning, functional expression, and distribution in human brain

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12 December 2020

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

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12 December 2020

Catalog of 258 single-nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptides, and three NADH:ubiquinone oxidoreductase flavoproteins

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12 December 2020

The effects of p-chlorophenylalanine, a serotonin depletor, on avoidance acquisition, pain sensitivity and related behavior in the rat

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12 December 2020

Interaction of methadone with substrates of human hepatic cytochrome P450 3A4.

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12 December 2020

The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine

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12 December 2020

Identification and functional characterization of alpha(2)-adrenoceptor polymorphisms

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12 December 2020

Association studies of the HOPA dodecamer duplication variant in different subtypes of autism

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12 December 2020

Long lasting respiratory depression induced by morphine-6-glucuronide?

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12 December 2020

CYP2D6 phenotype determines the metabolic conversion of hydrocodone to hydromorphone.

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12 December 2020

Gender differences in response to drugs: pain medications.

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12 December 2020

Effect of 5-hydroxytryptamine precursors on morphine analgesia in the formalin test

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12 December 2020

Acute tryptophan depletion blocks morphine analgesia in the cold-pressor test in humans

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12 December 2020

Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception

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12 December 2020

The d- and l-isomers of methadone bind to the non-competitive site on the N-methyl-D-aspartate (NMDA) receptor in rat forebrain and spinal cord.

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12 December 2020

Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction

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12 December 2020

Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization

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12 December 2020

Genetics of two mu opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol- and drug-dependent subjects

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12 December 2020

Human delta-opioid receptor gene and susceptibility to heroin and alcohol dependence

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12 December 2020

Epirubicin glucuronidation is catalyzed by human UDP-glucuronosyltransferase 2B7.

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12 December 2020

Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic

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12 December 2020

Interethnic differences in drug metabolism: influence of genetic and environmental factors on debrisoquine hydroxylation phenotype

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12 December 2020

Human mu opioid receptor gene polymorphisms and vulnerability to substance abuse.

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12 December 2020

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

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12 December 2020

Dihydrocodeine: a new opioid substrate for the polymorphic CYP2D6 in humans

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12 December 2020

Major vault protein LRP-related multidrug resistance

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12 December 2020

Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs.

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12 December 2020

Involvement of the multidrug resistance protein 3 in drug sensitivity and its expression in human glioma

1 reference

12 December 2020

Insidious intoxication after morphine treatment in renal failure: delayed onset of morphine-6-glucuronide action

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12 December 2020

N-methyl-D-aspartate receptor channel block by meperidine is dependent on extracellular pH.

1 reference

12 December 2020

Inhibition of cytochrome P450 2D6 metabolism of hydrocodone to hydromorphone does not importantly affect abuse liability.

1 reference

12 December 2020

Ritonavir's role in reducing fentanyl clearance and prolonging its half-life.

1 reference

12 December 2020

Polymorphic O-demethylation of codeine

1 reference

12 December 2020

Isolation and structural organization of the human preproenkephalin gene

1 reference

12 December 2020

Association analysis of polymorphisms in the μ opioid gene and heroin abuse in Chinese subjects.

1 reference

12 December 2020

Sex differences in morphine analgesia: an experimental study in healthy volunteers

1 reference

12 December 2020

Effects of the central analgesic tramadol on the uptake and release of noradrenaline and dopamine in vitro

1 reference

12 December 2020

The effect of quinidine on the analgesic effect of codeine

1 reference

12 December 2020

Dextromethorphan reduces immediate and late postoperative analgesic requirements and improves patients' subjective scorings after epidural lidocaine and general anesthesia

1 reference

12 December 2020

C3435T mutation in exon 26 of the human MDR1 gene and cyclosporine pharmacokinetics in healthy subjects.

1 reference

12 December 2020

Differences in postoperative pain severity among four ethnic groups

1 reference

12 December 2020

A pilot evaluation of alfentanil-induced miosis as a noninvasive probe for hepatic cytochrome P450 3A4 (CYP3A4) activity in humans

1 reference

12 December 2020

Opioid analgesics as noncompetitive N-methyl-D-aspartate (NMDA) antagonists

1 reference

12 December 2020

Rapid detection of the C3435T polymorphism of multidrug resistance gene 1 using fluorogenic hybridization probes

1 reference

12 December 2020

Duplication, multiduplication, and amplification of genes encoding drug-metabolizing enzymes: evolutionary, toxicological, and clinical pharmacological aspects

1 reference

12 December 2020

Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of [...]

1 reference

12 December 2020

Cyclooxygenase 1 (COX1) polymorphisms in African-American and Caucasian populations

1 reference

12 December 2020

Affinity, potency and efficacy of tramadol and its metabolites at the cloned human mu-opioid receptor

1 reference

12 December 2020

C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation

1 reference

12 December 2020

Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein.

1 reference

12 December 2020

Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome

1 reference

12 December 2020

Low frequency of slow debrisoquine hydroxylation in a native Chinese population

1 reference

12 December 2020

Morphine-fluoxetine interactions in healthy volunteers: analgesia and side effects

1 reference

12 December 2020

Regional expression and chromosomal localization of the delta opiate receptor gene

1 reference

12 December 2020

Polymorphic drug oxidation in humans

1 reference

12 December 2020

Single nucleotide polymorphisms in the human mu opioid receptor gene alter basal G protein coupling and calmodulin binding

1 reference

12 December 2020

The intrinsic antinociceptive effects of oxycodone appear to be kappa-opioid receptor mediated

1 reference

12 December 2020

Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19

1 reference

12 December 2020

Antinociceptive effects of morphine-6-glucuronide in homozygous MDR1a P-glycoprotein knockout and in wildtype mice in the hotplate test

1 reference

12 December 2020

Variation of the genes encoding the human glutamate EAAT2, serotonin and dopamine transporters and Susceptibility to idiopathic generalized epilepsy.

1 reference

12 December 2020

Antagonism of the analgesic effect of morphine and other drugs by p-chlorophenylalanine, a serotonin depletor

1 reference

12 December 2020

Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite.

1 reference

12 December 2020

Debrisoquine and dextromethorphan phenotyping and antidepressant treatment

1 reference

12 December 2020

Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism

1 reference

12 December 2020

Effect of chronic and acute administration of fluoxetine and its additive effect with morphine on the behavioural response in the formalin test in rats

1 reference

12 December 2020

Antinociceptive properties of fenfluramine, a serotonin reuptake inhibitor, in a rat model of neuropathy

1 reference

12 December 2020

Splice variants but not mutations of DNA polymerase beta are common in bladder cancer

1 reference

12 December 2020

Assignment of a serotonin 5HT-2 receptor gene (HTR2) to human chromosome 13q14-q21 and mouse chromosome 14

1 reference

12 December 2020

Interaction of the central analgesic, tramadol, with the uptake and release of 5-hydroxytryptamine in the rat brain in vitro

1 reference

12 December 2020

Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine.

1 reference

12 December 2020

Prostanoids and pain: unraveling mechanisms and revealing therapeutic targets

1 reference

12 December 2020

Effects of blocking CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone.

1 reference

12 December 2020

Ethnic differences in drug disposition and response.

1 reference

12 December 2020

Investigation of racial variations in the metabolism of tramadol

1 reference

12 December 2020

Evidence for P-glycoprotein-modulated penetration of morphine-6-glucuronide into brain capillary endothelium

1 reference

12 December 2020

Association between mu opioid receptor gene polymorphisms and Chinese heroin addicts

1 reference

12 December 2020

A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression

1 reference

12 December 2020

Contribution of monoaminergic modulation to the analgesic effect of tramadol

1 reference

12 December 2020

The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses

1 reference

12 December 2020

Identification and characterization of a prostaglandin transporter

1 reference

12 December 2020

Molecular genetics of CYP2D6: clinical relevance with focus on psychotropic drugs

1 reference

12 December 2020

Allelic variation of human serotonin transporter gene expression

1 reference

12 December 2020

Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations

1 reference

12 December 2020

Affinities of dihydrocodeine and its metabolites to opioid receptors

1 reference

12 December 2020

Interethnic differences in pain perception

1 reference

12 December 2020

Morphine-6-glucuronide might mediate the prolonged opioid effect of morphine in acute renal failure

1 reference

12 December 2020

Mu opioid receptor gene variants: lack of association with alcohol dependence

1 reference

12 December 2020

Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol

1 reference

12 December 2020

Analgesic and immunomodulatory effects of codeine and codeine 6-glucuronide

1 reference

12 December 2020

The influence of inhibition of probenecid sensitive transporters on the central nervous system (CNS) uptake and the antinociceptive activity of morphine-6-glucuronide in rats

1 reference

12 December 2020

Variant detection at the delta opioid receptor (OPRD1) locus and population genetics of a novel variant affecting protein sequence

1 reference

12 December 2020

Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.

1 reference

12 December 2020

Cultural and educational influences on pain of childbirth

1 reference

12 December 2020

Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients

1 reference

12 December 2020

Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin

1 reference

12 December 2020

Human UGT2B7 catalyzes morphine glucuronidation

1 reference

12 December 2020

Paroxetine increases steady-state concentrations of (R)-methadone in CYP2D6 extensive but not poor metabolizers

1 reference

12 December 2020

The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268).

1 reference

12 December 2020

Clinical significance of the cytochrome P450 2C19 genetic polymorphism

1 reference

12 December 2020

Possible association of temporomandibular joint pain and dysfunction with a polymorphism in the serotonin transporter gene

1 reference

12 December 2020

Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C.

1 reference

12 December 2020

Glucuronidation in humans. Pharmacogenetic and developmental aspects

1 reference

12 December 2020

Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)

1 reference

12 December 2020

Opioids and non-opioid enantiomers selectively attenuate N-methyl-D-aspartate neurotoxicity on cortical neurons

1 reference

12 December 2020

kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system

1 reference

12 December 2020

Structural organization of human genomic DNA encoding the pro-opiomelanocortin peptide

1 reference

12 December 2020

Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome

1 reference

12 December 2020

Systematic review of outpatient services for chronic pain control.

1 reference

12 December 2020

Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans

1 reference

12 December 2020

Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects

1 reference

12 December 2020

Predictive factors of early morphine requirements in the post-anaesthesia care unit (PACU).

1 reference

12 December 2020

Heritability of nociception II. 'Types' of nociception revealed by genetic correlation analysis

1 reference

12 December 2020

Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy

1 reference

12 December 2020

Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3

1 reference

12 December 2020

Opioid receptor interactions of butorphanol, a narcotic antagonist analgesic, and its metabolites

1 reference

12 December 2020

Effect of fluvoxamine on sufentanil antinociception and tolerance under chronic intravenous infusion in rats.

1 reference

12 December 2020

Deriving dichotomous outcome measures from continuous data in randomised controlled trials of analgesics

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12 December 2020

[Duality of the analgesic effect of tramadol in humans]

1 reference

12 December 2020

The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade

1 reference

12 December 2020

Opiate-induced analgesia is increased and prolonged in mice lacking P-glycoprotein

1 reference

12 December 2020

Mutation analysis of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) in schizophrenia

1 reference

12 December 2020

Metabolism of fentanyl, a synthetic opioid analgesic, by human liver microsomes. Role of CYP3A4.

1 reference

12 December 2020

Patient-controlled analgesia (PCA) with codeine for postoperative pain relief in ten extensive metabolisers and one poor metaboliser of dextromethorphan

1 reference

12 December 2020

Affinity profiles of morphine, codeine, dihydrocodeine and their glucuronides at opioid receptor subtypes

1 reference

12 December 2020

Molecular basis of ethnic differences in drug disposition and response

1 reference

12 December 2020

Gender variations in clinical pain experience

1 reference

12 December 2020

Cytochrome P450 2D6 Genotype and Methadone Steady-State Concentrations

1 reference

12 December 2020

Pharmacogenetic determination of the effects of codeine and prediction of drug interactions

1 reference

12 December 2020

Actions of tramadol, its enantiomers and principal metabolite, O-desmethyltramadol, on serotonin (5-HT) efflux and uptake in the rat dorsal raphe nucleus

1 reference

12 December 2020

Mrp2 is essential for estradiol-17beta(beta-D-glucuronide)-induced cholestasis in rats

1 reference

12 December 2020

Gender and age influences on human brain mu-opioid receptor binding measured by PET.

1 reference

12 December 2020

Increased drug delivery to the brain by P-glycoprotein inhibition

1 reference

12 December 2020

Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance

1 reference

12 December 2020

Influence of L-tryptophan on morphine analgesia, tolerance and physical dependence

1 reference

12 December 2020

Inhibition of cytochrome P450 2D6 modifies codeine abuse liability

1 reference

12 December 2020

Pharmacogenetics of the human drug-transporter gene MDR1: impact of polymorphisms on pharmacotherapy

1 reference

12 December 2020

Effects of tramadol stereoisomers on norepinephrine efflux and uptake in the rat locus coeruleus measured by real time voltammetry.

1 reference

12 December 2020

Identification of 779 genetic variations in eight genes encoding members of the ATP-binding cassette, subfamily C (ABCC/MRP/CFTR

1 reference

12 December 2020

A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome

1 reference

12 December 2020

Enhancement of morphine analgesia by fenfluramine in subjects receiving tailored opioid infusions

1 reference

12 December 2020

Impact of quinidine on plasma and cerebrospinal fluid concentrations of codeine and morphine after codeine intake

1 reference

12 December 2020

Methadone withdrawal when starting an antiretroviral regimen including nevirapine

1 reference

12 December 2020

Concordance between tramadol and dextromethorphan parent/metabolite ratios: the influence of CYP2D6 and non-CYP2D6 pathways on biotransformation

1 reference

12 December 2020

A functional polymorphism within the mu-opioid receptor gene and risk for abuse of alcohol and other substances

1 reference

12 December 2020

Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier

1 reference

12 December 2020

Localization of the CYP2D gene locus to human chromosome 22q13.1 by polymerase chain reaction, in situ hybridization, and linkage analysis

1 reference

12 December 2020

Functionally gene-linked polymorphic regions and genetically controlled neurotransmitters metabolism

1 reference

12 December 2020

The CYP 3A4 inhibitor itraconazole has no effect on the pharmacokinetics of i.v. fentanyl.

1 reference

12 December 2020

The T102C polymorphism of the 5-HT2A-receptor gene in fibromyalgia

1 reference

12 December 2020

Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans

1 reference

12 December 2020

Nonreplication of association between mu-opioid-receptor gene (OPRM1) A118G polymorphism and substance dependence

1 reference

12 December 2020

Evidence for polymorphic oxidation of sparteine in Japanese subjects

1 reference

12 December 2020

Distinct haplotype profiles and strong linkage disequilibrium at the MDR1 multidrug transporter gene locus in three ethnic Asian populations

1 reference

12 December 2020

Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa.

1 reference

12 December 2020

MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity

1 reference

12 December 2020

Prospective CYP2D6 genotyping as an exclusion criterion for enrollment of a phase III clinical trial

1 reference

12 December 2020

Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment

1 reference

12 December 2020

Studies on pain. Effects of morphine on a spinal nociceptive flexion reflex and related pain sensation in man.

1 reference

12 December 2020

Prolongation of morphine anaesthesia in a patient with Gilbert's disease: Report of a case

1 reference

12 December 2020

MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine

1 reference

12 December 2020

Polymorphisms of mu and delta opioid receptor genes and tardive dyskinesia in patients with schizophrenia

1 reference

12 December 2020

1 reference

12 December 2020

Purification and characterization of rat liver naloxone reductase that is identical to 3alpha-hydroxysteroid dehydrogenase

1 reference

12 December 2020

Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations

1 reference

12 December 2020

Effect of preoperative oral dextromethorphan on immediate and late postoperative pain and hyperalgesia after total abdominal hysterectomy.

1 reference

12 December 2020

Release studies with rat brain cortical synaptosomes indicate that tramadol is a 5-hydroxytryptamine uptake blocker and not a 5-hydroxytryptamine releaser.

1 reference

12 December 2020

A family of drug transporters: the multidrug resistance-associated proteins.

1 reference

12 December 2020

Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene

1 reference

12 December 2020

Genetic variation in cyclooxygenase 1: effects on response to aspirin

1 reference

12 December 2020

A comparison of the pharmacokinetics of codeine and its metabolites in healthy Chinese and Caucasian extensive hydroxylators of debrisoquine

1 reference

12 December 2020

Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects.

1 reference

12 December 2020

Interethnic differences of drug-metabolizing enzymes.

1 reference

12 December 2020

Possible association of fibromyalgia with a polymorphism in the serotonin transporter gene regulatory region

1 reference

12 December 2020

Nalbuphine: an autoradiographic opioid receptor binding profile in the central nervous system of an agonist/antagonist analgesic

1 reference

12 December 2020

Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein

1 reference

12 December 2020

Rifampicin and methadone withdrawal

1 reference

12 December 2020

Physiological genomics of antidepressant targets: keeping the periphery in mind.

1 reference

12 December 2020

The control of pain in peripheral tissue by opioids.

1 reference

12 December 2020

Transport of the beta -O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1). Requirement for glutathione or a non-sulfur-containing analog

1 reference

12 December 2020

Transport of glutathione conjugates and glucuronides by the multidrug resistance proteins MRP1 and MRP2.

1 reference

12 December 2020

Sequence Variability and Candidate Gene Analysis in Two Cancer Patients with Complex Clinical Outcomes During Morphine Therapy

1 reference

12 December 2020

Human alfentanil metabolism by cytochrome P450 3A3/4. An explanation for the interindividual variability in alfentanil clearance?

1 reference

12 December 2020

Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteers

1 reference

12 December 2020

Mu receptor binding of some commonly used opioids and their metabolites

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12 December 2020

Analgesic effect and plasma concentrations of codeine and morphine after two dose levels of codeine following oral surgery

1 reference

12 December 2020

Glucuronidation of dihydrocodeine by human liver microsomes and the effect of inhibitors.

1 reference

12 December 2020

Modelling of the blood-brain barrier transport of morphine-3-glucuronide studied using microdialysis in the rat: involvement of probenecid-sensitive transport

1 reference

12 December 2020

Kinetic and biochemical analysis of carrier-mediated efflux of drugs through the blood-brain and blood-cerebrospinal fluid barriers: importance in the drug delivery to the brain

1 reference

12 December 2020

Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis

1 reference

12 December 2020

Serotonergic genes and suicidality

1 reference

12 December 2020

Association between clozapine response and allelic variation in 5-HT2A receptor gene

1 reference

12 December 2020

Serotonin transporter polymorphism and response to SSRIs in major depression and relevance to anxiety disorders and substance abuse

1 reference

12 December 2020

Ethnic differences of the primary gene defect at the cytochrome P-450 2D6

1 reference

12 December 2020

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

1 reference

12 December 2020

Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter

1 reference

12 December 2020

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

1 reference

12 December 2020

A sex difference in the effects of oral codeine and promethazine on the ventilatory response to carbon dioxide in human volunteers

1 reference

12 December 2020

Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study

1 reference

12 December 2020

Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene

1 reference

12 December 2020

G protein beta3 gene variant, vascular function, and insulin sensitivity in type 2 diabetes.

1 reference

12 December 2020

Kappa-opioids produce significantly greater analgesia in women than in men.

1 reference

12 December 2020

The visceral and somatic antinociceptive effects of dihydrocodeine and its metabolite, dihydromorphine. A cross-over study with extensive and quinidine-induced poor metabolizers

1 reference

12 December 2020

Impaired receptor binding and activation associated with a human prostacyclin receptor polymorphism

1 reference

12 December 2020

Mutation analysis of protein kinase A catalytic subunit in thyroid adenomas and pituitary tumours

1 reference

12 December 2020

Ketobemidone, methadone and pethidine are non-competitive N-methyl-D-aspartate (NMDA) antagonists in the rat cortex and spinal cord

1 reference

12 December 2020

Molecular genetic basis of Gilbert's syndrome

1 reference

12 December 2020

A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation

1 reference

12 December 2020

Impact of environmental and genetic factors on codeine analgesia

1 reference

12 December 2020

Cyclooxygenase-2 polymorphism: putting a brake on the inflammatory response to vascular injury?

1 reference

12 December 2020

Potentiation of morphine analgesia after pretreatment with probenecid or sulfinpyrazone.

1 reference

12 December 2020

The effect of codeine on gastrointestinal transit in extensive and poor metabolisers of debrisoquine

1 reference

12 December 2020

The hypoalgesic effect of tramadol in relation to CYP2D6*

1 reference

12 December 2020

Association analysis for genetic variants of the NMDA receptor 2b subunit (GRIN2B) and Parkinson's disease

1 reference

12 December 2020

Identification of functionally variant MDR1 alleles among European Americans and African Americans

1 reference

12 December 2020

Increased CNS uptake and enhanced antinociception of morphine-6-glucuronide in rats after inhibition of P-glycoprotein

1 reference

12 December 2020

Effects of polymorphisms of MDR1, MRP1, and MRP2 genes on their mRNA expression levels in duodenal enterocytes of healthy Japanese subjects

1 reference

12 December 2020

Ultrarapid metabolism of sparteine: frequency of alleles with duplicated CYP2D6 genes in a Danish population as determined by restriction fragment length polymorphism and long polymerase chain reaction.

1 reference

12 December 2020

Functional characterization of coding polymorphisms in the human MDR1 gene using a vaccinia virus expression system.

1 reference

12 December 2020

Rifampin-induced methadone withdrawal in AIDS

1 reference

12 December 2020

Cytochrome P450 2D6 and treatment of codeine dependence.

1 reference

12 December 2020

Association between a delta opioid receptor gene polymorphism and heroin dependence in man.

1 reference

12 December 2020

Transport of opioids from the brain to the periphery by P-glycoprotein: peripheral actions of central drugs

1 reference

12 December 2020

Codeine disposition in smokers and nonsmokers

1 reference

12 December 2020

The N-methyl-D-aspartate antagonistic and opioid components of d-methadone antinociception in the rat spinal cord

1 reference

12 December 2020

Ethnicity influences morphine pharmacokinetics and pharmacodynamics

1 reference

12 December 2020

Gender differences in opioid-mediated analgesia: animal and human studies

1 reference

12 December 2020

Perioperative dextromethorphan reduces postoperative pain after hysterectomy.

1 reference

12 December 2020

Polymorphisms in genes involved in neurotransmission in relation to smoking

1 reference

12 December 2020

Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception

1 reference

12 December 2020

Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes

1 reference

12 December 2020

Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein

1 reference

12 December 2020

The antinociceptive effect of tramadol in the formalin test is mediated by the serotonergic component

1 reference

12 December 2020

The opioid receptor system and alcoholism: a genetic perspective.

1 reference

12 December 2020

Purification and characterization of two major forms of naloxone reductase from rabbit liver cytosol, new members of aldo-keto reductase superfamily

1 reference

12 December 2020

MDR1 genotype-related pharmacokinetics and pharmacodynamics.

1 reference

12 December 2020

Modeling of the in vivo antinociceptive interaction between an opioid agonist, (+)-O-desmethyltramadol, and a monoamine reuptake inhibitor, (-)-O-desmethyltramadol, in rats

1 reference

12 December 2020

Association of a functional mu-opioid receptor allele (+118A) with alcohol dependency

1 reference

12 December 2020

Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene

1 reference

12 December 2020

The Sequence of the Human Genome

1 reference

12 December 2020

Antisense mapping of MOR-1 in rats: distinguishing between morphine and morphine-6beta-glucuronide antinociception

1 reference

12 December 2020

d-Methadone blocks morphine tolerance and N-methyl-D-aspartate-induced hyperalgesia

1 reference

12 December 2020

Mutation analysis of the NMDAR2B (GRIN2B) gene in schizophrenia

1 reference

12 December 2020

Codeine and morphine in extensive and poor metabolizers of sparteine: pharmacokinetics, analgesic effect and side effects

1 reference

12 December 2020

Heteromeric NMDA receptors: molecular and functional distinction of subtypes

1 reference

12 December 2020

Interactions between fluoxetine and opiate analgesia for postoperative dental pain.

1 reference

12 December 2020

Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver

1 reference

12 December 2020

Single-step assays to analyze CYP2D6 gene polymorphisms in Asians: allele frequencies and a novel *14B allele in mainland Chinese

1 reference

12 December 2020

Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence

1 reference

12 December 2020

Opioid receptor and peptide gene polymorphisms: potential implications for addictions

1 reference

12 December 2020

Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population

1 reference

12 December 2020

Opioid binding profiles of new hydrazone, oxime, carbazone and semicarbazone derivatives of 14-alkoxymorphinans.

1 reference

12 December 2020

Potentiation of kappa-opioid receptor agonist-induced analgesia and hypothermia by fluoxetine

1 reference

12 December 2020

Methadone: opioid, N-methyl-D-aspartate antagonist or both?

1 reference

12 December 2020

Polymorphisms in CYP2D6 duplication-negative individuals with the ultrarapid metabolizer phenotype: a role for the CYP2D6*35 allele in ultrarapid metabolism?

1 reference

12 December 2020

Codeine analgesia is due to codeine-6-glucuronide, not morphine

1 reference

12 December 2020

Role of transporters in the tissue-selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney

1 reference

12 December 2020

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1 reference

12 December 2020

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

1 reference

12 December 2020

Chronic idiopathic jaundice with unidentified pigment in liver cells; a new clinicopathologic entity with a report of 12 cases

1 reference

12 December 2020

Multiple opioid receptors: ligand selectivity profiles and binding site signatures

1 reference

12 December 2020

Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine.

1 reference

12 December 2020

The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene

1 reference

12 December 2020

The kappa opioid nalbuphine produces gender- and dose-dependent analgesia and antianalgesia in patients with postoperative pain

1 reference

12 December 2020

Sequence variability and candidate gene analysis in complex disease: association of mu opioid receptor gene variation with substance dependence

1 reference

12 December 2020

Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor

1 reference

12 December 2020

A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling

1 reference

12 December 2020

Ultrarapid metabolizers of debrisoquine: Characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene

1 reference

12 December 2020

Pindolol, a beta-adrenoceptor blocker/5-hydroxytryptamine(1A/1B) antagonist, enhances the analgesic effect of tramadol

1 reference

12 December 2020

The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells

1 reference

12 December 2020

Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

1 reference

12 December 2020

An inventory of the human ABC proteins

1 reference

12 December 2020

Alcohol consumption alters the pharmacodynamics of alfentanil.

1 reference

12 December 2020

Codeine O-demethylation co-segregates with polymorphic debrisoquine hydroxylation

1 reference

12 December 2020

Personality and polymorphisms of genes involved in aminergic neurotransmission

1 reference

12 December 2020

Localization of the kappa opioid receptor gene to human chromosome band 8q11.2.

1 reference

12 December 2020

Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine

1 reference

12 December 2020

Impact of ethnic origin and quinidine coadministration on codeine's disposition and pharmacodynamic effects

1 reference

12 December 2020

Inhibition of human cytochrome P450 2D6 (CYP2D6) by methadone

1 reference

12 December 2020

Reduction of drug ketones by dihydrodiol dehydrogenases, carbonyl reductase and aldehyde reductase of human liver

1 reference

12 December 2020

Allelic variation S268P of the human mu-opioid receptor affects both desensitization and G protein coupling.

1 reference

12 December 2020

Decreased methadone effect after ritonavir initiation

1 reference

12 December 2020

Genetic variation of the glutamate transporter EAAT2 gene and vulnerability to alcohol dependence

1 reference

12 December 2020

Effect of P-glycoprotein modulation on the clinical pharmacokinetics and adverse effects of morphine

1 reference

12 December 2020

Genetic polymorphisms of the human MDR1 drug transporter

1 reference

12 December 2020

Evidence for a role of cytochrome P450 2D6 and 3A4 in ethylmorphine metabolism

1 reference

12 December 2020

The effects of the human MDR1 genotype on the expression of duodenal P-glycoprotein and disposition of the probe drug talinolol.

1 reference

12 December 2020

Effect of codeine on gastrointestinal motility in relation to CYP2D6 phenotype*

1 reference

12 December 2020

d-morphine, but not l-morphine, has low micromolar affinity for the non-competitive N-methyl-D-aspartate site in rat forebrain. Possible clinical implications for the management of neuropathic pain.

1 reference

12 December 2020

Metabolic and ethnic determinants of alcohol drinking habits and vulnerability to alcohol-related disorder.

1 reference

12 December 2020

The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation.

1 reference

12 December 2020

Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3).

1 reference

12 December 2020

mu-opioid receptor-mediated antinociceptive responses differ in men and women.

1 reference

12 December 2020

Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome

1 reference

12 December 2020

CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity

1 reference

12 December 2020

Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA

1 reference

12 December 2020

MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects

1 reference

12 December 2020

Ethnicity and the pain experience.

1 reference

12 December 2020

Cloning and expression of human liver UDP-glucuronosyltransferase in COS-1 cells. 3,4-catechol estrogens and estriol as primary substrates

1 reference

12 December 2020

Tramadol, M1 metabolite and enantiomer affinities for cloned human opioid receptors expressed in transfected HN9.10 neuroblastoma cells

1 reference

12 December 2020

Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation

1 reference

12 December 2020

A dimensional impulsive-aggressive phenotype is associated with the A218C polymorphism of the tryptophan hydroxylase gene: a pilot study in well-characterized impulsive inpatients.

1 reference

12 December 2020

Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier

1 reference

12 December 2020

Identification of single nucleotide polymorphisms (SNPs) and other sequence changes and estimation of nucleotide diversity in coding and flanking regions of the NMDAR1 receptor gene in schizophrenic patients

1 reference

12 December 2020

The analgesic efficacy of tramadol is impaired by concurrent administration of ondansetron

1 reference

12 December 2020

Frequency of C3435T polymorphism of MDR1 gene in African people

1 reference

12 December 2020

The pharmacogenetics of codeine hypoalgesia.

1 reference

12 December 2020

Morphine formation from codeine in rat brain: a possible mechanism of codeine analgesia.

1 reference

12 December 2020

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine

1 reference

12 December 2020

Tryptophan loading may reverse tolerance to opiate analgesics in humans: a preliminary report

1 reference

12 December 2020

Human buprenorphine N-dealkylation is catalyzed by cytochrome P450 3A4.

1 reference

12 December 2020

The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome

1 reference

12 December 2020

Differential antinociception by morphine and methadone in two sub-strains of Sprague-Dawley rats and its potentiation by dextromethorphan

1 reference

12 December 2020

Novel polymorphism in the gene region encoding the carboxyl-terminal intracellular domain of the NMDA receptor 2B subunit: analysis of association with schizophrenia

1 reference

12 December 2020

The effect of biogenic amine modifiers on morphine analgesia and its antagonism by naloxone

1 reference

12 December 2020

Codeine in post-operative pain

1 reference

12 December 2020

Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine

1 reference

12 December 2020

The organic anion transporter family: from physiology to ontogeny and the clinic

1 reference

12 December 2020

Initial sequencing and analysis of the human genome

1 reference

12 December 2020

Polymorphic CYP2D6 mediates O-demethylation of the opioid analgesic tramadol

1 reference

12 December 2020

10.2165/00003088-200443140-00003

Identifiers

DOI

1 reference

PubMed ID

15530129

Dimensions Publication ID

11 August 2017

0 references

1 reference

PubMed ID

15530129