Evolution of a highly polymorphic human cytochrome P450 gene cluster: CYP2D6. (Q48159900)

9 February 2018

title

Evolution of a highly polymorphic human cytochrome P450 gene cluster: CYP2D6. (English)

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9 February 2018

author

Markus H Heim

series ordinal

1

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9 February 2018

author name string

Meyer UA

series ordinal

2

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9 February 2018

publication date

1 September 1992

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9 February 2018

published in

Genomics

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9 February 2018

volume

14

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9 February 2018

page(s)

49-58

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9 February 2018

issue

1

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9 February 2018

Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population

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Xenobiotic and endobiotic inhibitors of cytochrome P-450dbl function, the target of the debrisoquine/sparteine type polymorphism

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Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.

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Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

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Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation

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Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

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Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing

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Interethnic variation of drug metabolism

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Evolutionary Rate at the Molecular Level

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The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats.

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The rat P450 IID subfamily: complete sequences of four closely linked genes and evidence that gene conversions maintained sequence homogeneity at the heme-binding region of the cytochrome P450 active site

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The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature

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Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype

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Hypermethylation of human DNA sequences in embryonal carcinoma cells and somatic tissues but not in sperm

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10.1016/S0888-7543(05)80282-4

Identifiers

DOI

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9 February 2018

PubMed ID

1358797

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9 February 2018