Polymorphisms of genes CYP2D6, ADRB1 and GNAS1 in pharmacokinetics and systemic effects of ophthalmic timolol. A pilot study (Q57417587)

9

object named as

Terho Lehtimäki

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Hannu Uusitalo

2

object named as

Hannu Uusitalo

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author name string

Tuomo Nieminen

1

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Jukka Mäenpää

3

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Väinö Turjanmaa

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Anders Rane

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Stefan Lundgren

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Auli Ropo

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Riikka Rontu

European Journal of Clinical Pharmacology

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publication date

17 November 2005

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published in

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volume

61

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issue

11

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page(s)

811-819

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exact match

https://scigraph.springernature.com/pub.10.1007/s00228-005-0052-4

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cites work

Timolol metabolism and debrisoquine oxidation polymorphism: a population study

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Timolol and atenolol: relationships between oxidation phenotype, pharmacokinetics and pharmacodynamics

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00228-005-0052-4

Adverse reactions from timolol administration

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00228-005-0052-4

A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor

21 January 2018

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12 December 2020

Impact of the ultrarapid metabolizer genotype of cytochrome P450 2D6 on metoprolol pharmacokinetics and pharmacodynamics

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12 December 2020

Effect of the CYP2D6 genotype on metoprolol metabolism persists during long-term treatment

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12 December 2020

The gain-of-function G389R variant of the beta1-adrenoceptor does not influence blood pressure or heart rate response to beta-blockade in hypertensive subjects

1 reference

12 December 2020

Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension

1 reference

12 December 2020

Cardiovascular effects of ophthalmic 0.5% timolol aqueous solution and 0.1% timolol hydrogel

1 reference

12 December 2020

Influence of the cytochrome P4502D6*4 allele on the pharmacokinetics of controlled-release metoprolol.

1 reference

12 December 2020

Amino acid 49 polymorphisms of the human beta1-adrenergic receptor affect agonist-promoted trafficking

1 reference

12 December 2020

Beta 1- and beta 2-adrenoceptors in the human heart: properties, function, and alterations in chronic heart failure

1 reference

12 December 2020

Association between low plasma levels of ophthalmic timolol and haemodynamics in glaucoma patients.

1 reference

12 December 2020

The polymorphic oxidation of beta-adrenoceptor antagonists. Clinical pharmacokinetic considerations

1 reference

12 December 2020

Comparison of the cardiovascular effects of unoprostone 0.15%, timolol 0.5% and placebo in healthy adults during exercise using a treadmill test

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12 December 2020

Pharmacogenomics: translating functional genomics into rational therapeutics

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12 December 2020

Pharmacology and physiology of human adrenergic receptor polymorphisms

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12 December 2020

Allelic discrimination using fluorogenic probes and the 5' nuclease assay

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12 December 2020

Optimized Strategy for Rapid Cytochrome P450 2D6 Genotyping by Real-Time Long PCR

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12 December 2020

Association of the G(s)alpha gene with essential hypertension and response to beta-blockade

1 reference

12 December 2020

The effects of timolol on intraocular pressure and exercise heart rate in poor and extensive debrisoquine metabolizers

1 reference

12 December 2020

Randomised, controlled trial of spirometric changes in elderly people receiving timolol or betaxolol as initial treatment for glaucoma

1 reference

12 December 2020

Inotropic and sympathetic responses to the intracoronary infusion of a beta2-receptor agonist: a human in vivo study

1 reference

12 December 2020

Polymorphic metabolism of the beta-adrenoreceptor blocking drugs and its clinical relevance

1 reference

12 December 2020

Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol

1 reference

12 December 2020

Polymorphisms of adrenergic receptors: variations on a theme

1 reference

12 December 2020

Pharmacogenomics and drug response in cardiovascular disorders

1 reference

12 December 2020

Pharmacokinetics and beta-blocking effects of timolol in poor and extensive metabolizers of debrisoquin

1 reference

12 December 2020

A common beta1-adrenergic receptor polymorphism (Arg389Gly) affects blood pressure response to beta-blockade

1 reference

12 December 2020

The myocardium-protective Gly-49 variant of the beta 1-adrenergic receptor exhibits constitutive activity and increased desensitization and down-regulation

1 reference

12 December 2020

Timolol 0.1% gel (Nyogel 0.1% once daily versus conventional timolol 0.5% solution twice daily: a comparison of efficacy and safety

1 reference

12 December 2020

Systemic absorption of ocular timolol in poor and extensive metabolizers of debrisoquine

1 reference

12 December 2020

Effects of glaucoma medications on the cardiorespiratory and intraocular pressure status of newly diagnosed glaucoma patients

1 reference

12 December 2020

Pharmacogenetic explanation for excessive beta-blockade following timolol eye drops. Potential for oral-ophthalmic drug interaction

1 reference

12 December 2020

The analysis of plasma kinetics and beta-receptor binding and -blocking activity of timolol following its small intravenous dose

1 reference

12 December 2020