TBX2 and TBX3: the special value for anticancer drug targets. (Q34125637)

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7 February 2020

review article

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title

TBX2 and TBX3: the special value for anticancer drug targets (English)

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7 February 2020

5

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7 February 2020

Ming-Liang He

6

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7 February 2020

author name string

Juan Lu

1

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7 February 2020

Xiang-Ping Li

2

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7 February 2020

Qi Dong

3

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7 February 2020

Hsiang-Fu Kung

4

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7 February 2020

language of work or name

English

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publication date

17 July 2010

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7 February 2020

number of pages

7

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Biochimica et Biophysica Acta

inferred from page(s)

published in

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7 February 2020

volume

1806

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7 February 2020

issue

2

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7 February 2020

page(s)

268-274

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Tumor cell senescence in cancer treatment

7 February 2020

cites work

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Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.

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Characterization of the TBX5 binding site and analysis of mutations that cause Holt-Oram syndrome

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Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

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Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6

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Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family

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TBX3 and its splice variant TBX3 + exon 2a are functionally similar.

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p21 is necessary for the p53-mediated G1 arrest in human cancer cells

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Cloning of the T gene required in mesoderm formation in the mouse

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A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins

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Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas

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TBX3 and its isoform TBX3+2a are functionally distinctive in inhibition of senescence and are overexpressed in a subset of breast cancer cell lines

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The retinoblastoma protein modulates Tbx2 functional specificity

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Synthetic peptides outside the spike protein heptad repeat regions as potent inhibitors of SARS-associated coronavirus

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Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule

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Histone deacetylase inhibitors in cancer therapy

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The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin.

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Tbx3 impinges on the p53 pathway to suppress apoptosis, facilitate cell transformation and block myogenic differentiation

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Genes differentially expressed in human lung fibroblast cells transformed by glycidyl methacrylate.

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TAT-mediated intracellular delivery of NPM-derived peptide induces apoptosis in leukemic cells and suppresses leukemogenesis in mice

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Evolution of mouse T-box genes by tandem duplication and cluster dispersion.

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Cellular senescence as a tumor-suppressor mechanism

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The T-box gene family

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TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases

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TBX2 is preferentially amplified in BRCA1- and BRCA2-related breast tumors

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Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome

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ERBB2, TBX2, RPS6KB1, and MYC alterations in breast tissues of BRCA1 and BRCA2 mutation carriers

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The regulation of E2F by pRB-family proteins

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Anchorage-independent growth of pocket protein-deficient murine fibroblasts requires bypass of G2 arrest and can be accomplished by expression of TBX2.

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The retinoblastoma protein and cell cycle control

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12 December 2020

Tbx20 interacts with smads to confine tbx2 expression to the atrioventricular canal

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12 December 2020

TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence

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12 December 2020

Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome

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12 December 2020

Wnt signalling mediated by Tbx2b regulates cell migration during formation of the neural plate.

1 reference

12 December 2020

TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins

1 reference

12 December 2020

A role for Tbx2 in the regulation of the alpha2(1) collagen gene in human fibroblasts

1 reference

12 December 2020

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

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12 December 2020

Frequent amplification of 8q24, 11q, 17q, and 20q-specific genes in pancreatic cancer

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12 December 2020

Gene expressions and copy numbers associated with metastatic phenotypes of uterine cervical cancer

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12 December 2020

Expression and clinical significance of tbx2 in pancreatic cancer.

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12 December 2020

T-box genes in early embryogenesis

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12 December 2020

Structural analysis of the 17q22-23 amplicon identifies several independent targets of amplification in breast cancer cell lines and tumors

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p21WAF1-derived peptides linked to an internalization peptide inhibit human cancer cell growth

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12 December 2020

Identification, characterization, and localization to chromosome 17q21-22 of the human TBX2 homolog, member of a conserved developmental gene family

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p14(ARF) regulates E2F activity

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12 December 2020

T-box 2 represses NDRG1 through an EGR1-dependent mechanism to drive the proliferation of breast cancer cells

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12 December 2020

Increased expression of cSHMT, Tbx3 and utrophin in plasma of ovarian and breast cancer patients

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12 December 2020

p53- and Mdm2-Independent Repression of NF-κB Transactivation by the ARF Tumor Suppressor

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12 December 2020

T-box genes: what they do and how they do it.

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12 December 2020

E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex

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The T-box transcription factor Tbx2: its role in development and possible implication in cancer

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Determinants of T box protein specificity.

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12 December 2020

A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells

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12 December 2020

Wnt signalling in stem cells and cancer

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12 December 2020

A homology domain shared between Drosophila optomotor-blind and mouse Brachyury is involved in DNA binding

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12 December 2020

Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome

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12 December 2020

E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer

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12 December 2020

Senescence of human fibroblasts induced by oncogenic Raf.

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12 December 2020

The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator

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12 December 2020

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12 December 2020

Tbx2 directly represses the expression of the p21(WAF1) cyclin-dependent kinase inhibitor

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12 December 2020

Crystallographic structure of the T domain-DNA complex of the Brachyury transcription factor

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12 December 2020