Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family (Q24311501)

GOA release 2020-03-11

forelimb morphogenesis

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GOA release 2020-03-11

T-box 5

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GOA release 2020-03-11

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S Lyonnet

12

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author name string

Q Y Li

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R A Newbury-Ecob

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J A Terrett

3

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D I Wilson

4

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A R Curtis

5

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C H Yi

6

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T Gebuhr

7

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P J Bullen

8

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S C Robson

9

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T Strachan

10

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D Bonnet

11

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I D Young

13

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J A Raeburn

14

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A J Buckler

15

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D J Law

16

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J D Brook

Linkage of the gene for Wolfram syndrome to markers on the short arm of chromosome 4

17

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publication date

January 1997

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language of work or name

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15

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issue

1

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page(s)

21-9

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cites work

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Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene

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Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene

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Holt-Oram syndrome is a genetically heterogeneous disease with one locus mapping to human chromosome 12q

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Cloning of the T gene required in mesoderm formation in the mouse

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An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus

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Genetic mapping of the human homologue (T) of mouse T(Brachyury) and a search for allele association between human T and spina bifida

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T-brain-1: a homolog of Brachyury whose expression defines molecularly distinct domains within the cerebral cortex

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Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome

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Identical mutations in three different fibroblast growth factor receptor genes in autosomal dominant craniosynostosis syndromes

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Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly

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GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families

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Mechanisms of limb patterning

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Limbs: a model for pattern formation within the vertebrate body plan

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Developmental genetics of the heart

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A gene for Holt–Oram syndrome maps to the distal long arm of chromosome 12

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The T genes in embryogenesis.

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Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center

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Conservation of the T-box gene family from Mus musculus to Caenorhabditis elegans

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Evidence of a role for T-box genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identity

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The identification of exons from the MED/PSACH region of human chromosome 19.

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Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome

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Altered growth and branching patterns in synpolydactyly caused by mutations in HOXD13

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Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alpha-thalassemia (ATR-X syndrome)

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Do we understand development?

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Vertebrate limb development

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The initiation of the limb bud: growth factors, Hox genes, and retinoids

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Holt-Oram syndrome: a clinical genetic study

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The clinical and genetic spectrum of the Holt-Oram syndrome (heart-hand syndrome)

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cDNA libraries from human tissues and cell lines

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The mouse Brachyury gene and mesoderm formation

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The T protein encoded by Brachyury is a tissue-specific transcription factor

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The human homolog T of the mouse T(Brachyury) gene; gene structure, cDNA sequence, and assignment to chromosome 6q27

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Expression of a xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction

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Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation

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The lethal(1)optomotor-blind gene of Drosophila melanogaster is a major organizer of optic lobe development: isolation and characterization of the gene

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A homology domain shared between Drosophila optomotor-blind and mouse Brachyury is involved in DNA binding

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Identification, characterization, and localization to chromosome 17q21-22 of the human TBX2 homolog, member of a conserved developmental gene family

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The Brachyury gene encodes a novel DNA binding protein

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Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development

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Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse

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Control of the gene optomotor-blind in Drosophila wing development by decapentaplegic and wingless

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A gene for ulnar-mammary syndrome maps to 12q23-q24.1.

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Generation and fluorescent in situ hybridization mapping of yeast artificial chromosomes of 1p, 17p, 17q, and 19q from a hybrid cell line by high-density screening of an amplified library

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Practical aspects of radio-isotopic in situ hybridization on RNA

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