Senescence of human fibroblasts induced by oncogenic Raf. (Q35210205)

7 August 2017

Senescence of human fibroblasts induced by oncogenic Raf. (English)

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7 August 2017

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J Zhu

1

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7 August 2017

D Woods

series ordinal

2

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7 August 2017

M McMahon

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3

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7 August 2017

J M Bishop

series ordinal

4

1 reference

7 August 2017

language of work or name

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1 October 1998

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7 August 2017

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7 August 2017

12

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7 August 2017

2997-3007

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7 August 2017

19

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describes a project that uses

7 August 2017

IMR-90/GFPdeltaRaf-1[YY]:ER

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Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

13 July 2018

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

13 July 2018

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

13 July 2018

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TRF2 Protects Human Telomeres from End-to-End Fusions

13 July 2018

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Extension of life-span by introduction of telomerase into normal human cells

13 July 2018

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

13 July 2018

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hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization

13 July 2018

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A survey of telomerase activity in human cancer

13 July 2018

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The biology of replicative senescence

13 July 2018

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Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53.

13 July 2018

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Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

13 July 2018

1 reference

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Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.

13 July 2018

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Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts

13 July 2018

1 reference

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Evidence for the inactivation of multiple replicative lifespan genes in immortal human squamous cell carcinoma keratinocytes.

13 July 2018

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The CDKN2A (p16) gene and human cancer.

13 July 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

13 July 2018

1 reference

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Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

13 July 2018

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Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects

13 July 2018

1 reference

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Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

13 July 2018

1 reference

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Episomal vectors rapidly and stably produce high-titer recombinant retrovirus

13 July 2018

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13 July 2018

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Regulation of transcription by MAP kinase cascades

13 July 2018

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Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer

13 July 2018

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Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6, but not E7, transformed human uroepithelial cells.

13 July 2018

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Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

13 July 2018

1 reference

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Cyclin dependent kinase regulation

13 July 2018

1 reference

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Replicative senescence: an old lives' tale?

13 July 2018

1 reference

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

13 July 2018

1 reference

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Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase

13 July 2018

1 reference

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WAF1, a potential mediator of p53 tumor suppression

13 July 2018

1 reference

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MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

13 July 2018

1 reference

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Raf meets Ras: completing the framework of a signal transduction pathway

13 July 2018

1 reference

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

13 July 2018

1 reference

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Increased p53 protein associated with aging in human diploid fibroblasts

13 July 2018

1 reference

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Production of high-titer helper-free retroviruses by transient transfection

13 July 2018

1 reference

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317194

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317194

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317194

Definition of the human raf amino-terminal regulatory region by deletion mutagenesis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317194

Improved retroviral vectors for gene transfer and expression

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317194

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317194

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317194

Cooperation between oncogenes

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317194

5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317194

Cooperating oncogenes converge to regulate cyclin/cdk complexes.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317194

Role of the INK4a locus in tumor suppression and cell mortality.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317194

Detection of 5-bromo-2-deoxyuridine (BrdUrd) incorporation with monoclonal anti-BrdUrd antibody after deoxyribonuclease treatment

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317194

Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317194

Raf regulates positive selection

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9765202

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Raf-1 kinase activity is necessary and sufficient for gene expression changes but not sufficient for cellular morphology changes associated with cardiac myocyte hypertrophy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9765202

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9765202

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1101/GAD.12.19.2997

1 reference

7 August 2017

1 reference

7 August 2017

1 reference