Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a (Q24324559)

Cyclin A2

1 reference

HRas proto-oncogene, GTPase

1 reference

Cyclin dependent kinase 2

1 reference

Cyclin dependent kinase inhibitor 1A

1 reference

tumor protein p53

1 reference

cyclin dependent kinase inhibitor 2A

1 reference

Ras protein signal transduction

1 reference

1 reference

Manuel Serrano Marugán

object named as

M Serrano

1

0 references

author name string

A W Lin

2

0 references

M E McCurrach

3

0 references

D Beach

4

0 references

S W Lowe

Investigation of the role of G1/S cell cycle mediators in cellular senescence

5

0 references

publication date

7 March 1997

0 references

language of work or name

0 references

0 references

88

0 references

issue

5

0 references

page(s)

593-602

0 references

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Increased activity of p53 in senescing fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

1 reference

7 January 2021

Differentiation of 3T3-L1 fibroblasts to adipocytes induced by transfection of ras oncogenes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

The ras gene family and human carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Radiation-induced cell cycle arrest compromised by p21 deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Signalling pathways: jack of all cascades

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

The in vitro lifespan of MRC-5 cells is shortened by 5-azacytidine-induced demethylation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

In vitro establishment is not a sufficient prerequisite for transformation by activated ras oncogenes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

CDC25 phosphatases as potential human oncogenes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Cdc25 cell-cycle phosphatase as a target of c-myc

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Overexpression of plasminogen activator inhibitor type-1 in senescent fibroblasts from normal subjects and those with Werner syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

The serial cultivation of human diploid cell strains

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Mutant p53 tumor suppressor alleles release ras-induced cell cycle growth arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Function of a human cyclin gene as an oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Rescue of cells from ras oncogene-induced growth arrest by a second, complementing, oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Strong effects of 5-azacytidine on the in vitro lifespan of human diploid fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Cooperation between oncogenes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Tumor spectrum analysis in p53-mutant mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Lessons from hereditary colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

p53: puzzle and paradigm

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Mitogenic effects of the proto-oncogene and oncogene forms of c-H-ras DNA in human diploid fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Absence of p53 allows direct immortalization of hematopoietic cells by the myc and raf oncogenes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Differential growth state‐dependent regulation of plasminogen activator inhibitor type‐1 expression in senescent IMR‐90 human diploid fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Inhibition of ras-induced proliferation and cellular transformation by p16INK4.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Role of the INK4a locus in tumor suppression and cell mortality

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Inhibitors of mammalian G1 cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Origins of G1 arrest in senescent human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Role of ceramide in cellular senescence

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

The multistep nature of cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

The retinoblastoma protein and cell cycle control

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981902-9

7 January 2021

10.1016/S0092-8674(00)81902-9

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

9054499

1 reference

Consolidated OpenCitations Corpus – April 2017