Inhibition of gamma-secretase as a therapeutic intervention for Alzheimer's disease: prospects, limitations and strategies (Q33243260)

24 July 2017

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title

Inhibition of gamma-secretase as a therapeutic intervention for Alzheimer's disease: prospects, limitations and strategies (English)

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24 July 2017

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3

Colin L Masters

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24 July 2017

Marijke Fleur Sernee

2

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author name string

Geneviève Evin

series ordinal

1

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24 July 2017

1 January 2006

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24 July 2017

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24 July 2017

20

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24 July 2017

351-372

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24 July 2017

5

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https://scigraph.springernature.com/pub.10.2165/00023210-200620050-00002

24 July 2017

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cites work

Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200620050-00002

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200620050-00002

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200620050-00002

Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200620050-00002

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

21 January 2018

1 reference

12 December 2020

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

12 December 2020

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

1 reference

12 December 2020

Drosophila presenilin is required for neuronal differentiation and affects notch subcellular localization and signaling.

1 reference

12 December 2020

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

12 December 2020

Protein topology of presenilin 1

1 reference

12 December 2020

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

1 reference

12 December 2020

Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation

1 reference

12 December 2020

Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation.

1 reference

12 December 2020

Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein

1 reference

12 December 2020

A sensitive and quantitative assay for measuring cleavage of presenilin substrates

1 reference

12 December 2020

Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.

1 reference

12 December 2020

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

12 December 2020

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

1 reference

12 December 2020

Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein.

1 reference

12 December 2020

Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain

1 reference

12 December 2020

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

1 reference

12 December 2020

Identification of signal peptide peptidase, a presenilin-type aspartic protease

1 reference

12 December 2020

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

1 reference

12 December 2020

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

1 reference

12 December 2020

Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability.

1 reference

12 December 2020

JLK isocoumarin inhibitors: selective gamma-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo

1 reference

12 December 2020

Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease.

1 reference

12 December 2020

A novel transmembrane topology of presenilin based on reconciling experimental and computational evidence

1 reference

12 December 2020

A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

1 reference

12 December 2020

Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.

1 reference

12 December 2020

Reconstitution of gamma-secretase activity

1 reference

12 December 2020

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

1 reference

12 December 2020

Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation

1 reference

12 December 2020

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

1 reference

12 December 2020

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

1 reference

12 December 2020

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

12 December 2020

Selecting cells with different Alzheimer's disease gamma-secretase activity using FACS. Differential effect on presenilin exon 9 gamma- and epsilon-cleavage

1 reference

12 December 2020

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

1 reference

12 December 2020

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

1 reference

12 December 2020

The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor

1 reference

12 December 2020

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

12 December 2020

Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals

1 reference

12 December 2020

Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

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12 December 2020

Shedding and gamma-secretase-mediated intramembrane proteolysis of the mucin-type molecule CD43.

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12 December 2020

In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.

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12 December 2020

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

1 reference

12 December 2020

The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase

1 reference

12 December 2020

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

1 reference

12 December 2020

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

1 reference

12 December 2020

Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging.

1 reference

12 December 2020

Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein.

1 reference

12 December 2020

Peptide-based, irreversible inhibitors of gamma-secretase activity

1 reference

12 December 2020

gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins

1 reference

12 December 2020

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

1 reference

12 December 2020

Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new beta-amyloid peptide production inhibitors and their activities on various classes of protease

1 reference

12 December 2020

Presenilin is required for proper morphology and function of neurons in C. elegans.

1 reference

12 December 2020

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

12 December 2020

Involvement of presenilins in cell-survival signalling pathways.

1 reference

12 December 2020

Evidence for a six-transmembrane domain structure of presenilin 1.

1 reference

12 December 2020

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1 reference

12 December 2020

APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development

1 reference

12 December 2020

The role of presenilin cofactors in the gamma-secretase complex

1 reference

12 December 2020

Implication of APP secretases in notch signaling

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12 December 2020

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

1 reference

12 December 2020

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

1 reference

12 December 2020

Membrane topology of Alzheimer's disease-related presenilin 1. Evidence for the existence of a molecular species with a seven membrane-spanning and one membrane-embedded structure

1 reference

12 December 2020

Gleevec inhibits β-amyloid production but not Notch cleavage

1 reference

12 December 2020

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

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12 December 2020

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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12 December 2020

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

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12 December 2020

Purification and characterization of the human gamma-secretase complex

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12 December 2020

Nicastrin functions as a gamma-secretase-substrate receptor

1 reference

12 December 2020

Amyloid plaque core protein in Alzheimer disease and Down syndrome

1 reference

12 December 2020

Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase

1 reference

12 December 2020

Selective inhibition of Abeta42 production by NSAID R-enantiomers

1 reference

12 December 2020

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

1 reference

12 December 2020

Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.

1 reference

12 December 2020

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

1 reference

12 December 2020

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

1 reference

12 December 2020

gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain

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12 December 2020

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

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12 December 2020

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

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12 December 2020

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

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12 December 2020

Three-dimensional structure of the γ-secretase complex

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12 December 2020

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

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12 December 2020

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

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12 December 2020

Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21

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12 December 2020

Presenilin-dependent processing and nuclear function of gamma-protocadherins.

1 reference

12 December 2020

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

1 reference

12 December 2020

An in vivo assay for the identification of target proteases which cleave membrane-associated substrates

1 reference

12 December 2020

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

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12 December 2020

Gamma-secretase complex assembly within the early secretory pathway

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12 December 2020

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

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12 December 2020

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

12 December 2020

A new functional screening system for identification of regulators for the generation of amyloid beta-protein

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12 December 2020

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

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12 December 2020

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

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12 December 2020

gamma-secretase cleavage is distinct from endoplasmic reticulum degradation of the transmembrane domain of the amyloid precursor protein

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12 December 2020

Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.

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12 December 2020

Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[

1 reference

12 December 2020

Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

1 reference

12 December 2020

Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

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12 December 2020

The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

1 reference

12 December 2020

Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.

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12 December 2020

A common enzyme connects notch signaling and Alzheimer's disease

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12 December 2020

Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications

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12 December 2020

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

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12 December 2020

Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway

1 reference

12 December 2020

Altered APP processing in PDAPP (Val717 --> Phe) transgenic mice yields extended-length Abeta peptides.

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12 December 2020

Cell-free assays for gamma-secretase activity

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12 December 2020

The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation

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12 December 2020

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

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12 December 2020

Distinct secretases, a cysteine protease and a serine protease, generate the C termini of amyloid beta-proteins Abeta1-40 and Abeta1-42, respectively

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12 December 2020

Evidence That Intramolecular Associations between Presenilin Domains Are Obligatory for Endoproteolytic Processing

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12 December 2020

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

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12 December 2020

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

12 December 2020

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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12 December 2020

Presenilins are not required for A beta 42 production in the early secretory pathway.

1 reference

12 December 2020

The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases

1 reference

12 December 2020

Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

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12 December 2020

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

12 December 2020

Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles

1 reference

12 December 2020

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

12 December 2020

Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.

1 reference

12 December 2020

Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain.

1 reference

12 December 2020

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

1 reference

12 December 2020

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

1 reference

12 December 2020

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

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12 December 2020

Identification of distinct gamma-secretase complexes with different APH-1 variants

1 reference

12 December 2020

Presenilin-dependent "gamma-secretase" processing of deleted in colorectal cancer (DCC)

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12 December 2020

Gene dosage effect on gamma-secretase component Aph-1b in a rat model for neurodevelopmental disorders

1 reference

12 December 2020

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

1 reference

12 December 2020

Glutamate Receptor Subunit 3 Is Modified by Site-specific Limited Proteolysis Including Cleavage by γ-Secretase

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12 December 2020

The gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester reduces A beta levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice

1 reference

12 December 2020

Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity.

1 reference

12 December 2020

Alzheimer's disease: genes, proteins, and therapy

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12 December 2020

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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12 December 2020

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

1 reference

12 December 2020

Genetic factors in the genesis of Alzheimer's disease

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12 December 2020

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

12 December 2020

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

1 reference

12 December 2020

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

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12 December 2020

The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments

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12 December 2020

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

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12 December 2020

A distinct ER/IC gamma-secretase competes with the proteasome for cleavage of APP

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12 December 2020

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

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12 December 2020

Cell-free generation of the notch1 intracellular domain (NICD) and APP-CTfgamma: evidence for distinct intramembranous "gamma-secretase" activities

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12 December 2020

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

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12 December 2020

gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site

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12 December 2020

Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage

1 reference

12 December 2020

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

12 December 2020

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

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12 December 2020

Notch signaling: control of cell communication and cell fate

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12 December 2020

Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage.

1 reference

12 December 2020

Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor

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12 December 2020

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

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12 December 2020

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

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12 December 2020

Dancing in the dark? The status of late-onset Alzheimer's disease genetics

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12 December 2020

A nine-transmembrane domain topology for presenilin 1

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12 December 2020

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

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12 December 2020

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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12 December 2020

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

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12 December 2020

Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct

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12 December 2020

Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase

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12 December 2020

The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage

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12 December 2020

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

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12 December 2020

Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).

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12 December 2020

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

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12 December 2020

Membrane topology of the C. elegans SEL-12 presenilin

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12 December 2020

Inhibition of beta-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

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12 December 2020

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

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12 December 2020

Amyloid, the presenilins and Alzheimer's disease

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12 December 2020

Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations

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12 December 2020

The Notch1 receptor is cleaved constitutively by a furin-like convertase

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12 December 2020

In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc

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12 December 2020

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

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12 December 2020

Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

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12 December 2020

Release of a membrane-bound death domain by gamma-secretase processing of the p75NTR homolog NRADD

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12 December 2020

A combinatorial approach to the identification of dipeptide aldehyde inhibitors of beta-amyloid production

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12 December 2020

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

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12 December 2020

Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase

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12 December 2020

Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase

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12 December 2020

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

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12 December 2020

Biogenesis and metabolism of Alzheimer's disease Abeta amyloid peptides

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12 December 2020

Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages

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12 December 2020

Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain

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12 December 2020

Intracellular production of beta A4 amyloid of Alzheimer's disease: modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein

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12 December 2020

What are the treatment options for patients with severe Alzheimer's disease?

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12 December 2020

Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease.

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12 December 2020

Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration

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12 December 2020

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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12 December 2020

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

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12 December 2020

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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12 December 2020

The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities

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12 December 2020

Compounds that bind APP and inhibit Abeta processing in vitro suggest a novel approach to Alzheimer disease therapeutics

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12 December 2020

Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

1 reference

12 December 2020

A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

1 reference

12 December 2020

The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities

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12 December 2020

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

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12 December 2020

Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases

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12 December 2020

Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

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12 December 2020

Activated Notch1 associates with a presenilin‐1/γ‐secretase docking site

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12 December 2020

Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts

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12 December 2020

Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation.

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12 December 2020

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

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12 December 2020

Topology of the C-terminal fragment of human presenilin 1.

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12 December 2020

The initial substrate-binding site of gamma-secretase is located on presenilin near the active site

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12 December 2020

gamma-Secretase as a target for drug intervention in Alzheimer's disease.

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12 December 2020

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

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12 December 2020

Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitor in volunteers

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12 December 2020

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

1 reference

12 December 2020

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

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12 December 2020

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

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12 December 2020

Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members

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12 December 2020

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

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12 December 2020

Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling

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12 December 2020

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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12 December 2020

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

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12 December 2020

L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth

1 reference

12 December 2020

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

12 December 2020

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

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12 December 2020

10.2165/00023210-200620050-00002

Identifiers

DOI

1 reference

PubMed ID

16696577

Dimensions Publication ID

24 July 2017

0 references

1 reference

PubMed ID

16696577