Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity. (Q31100408)

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11 November 2019

title

Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity (English)

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11 November 2019

1

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11 November 2019

author name string

Jonathan D J Wrigley

series ordinal

2

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11 November 2019

Andrew P Owens

series ordinal

3

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11 November 2019

Mark S Shearman

series ordinal

4

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11 November 2019

language of work or name

English

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publication date

1 August 2002

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Journal of Neurochemistry

11 November 2019

published in

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11 November 2019

volume

82

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11 November 2019

page(s)

563-575

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11 November 2019

issue

3

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Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

11 November 2019

cites work

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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

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BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

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