A new functional screening system for identification of regulators for the generation of amyloid beta-protein (Q30840824)

27 June 2017

A new functional screening system for identification of regulators for the generation of amyloid beta-protein (English)

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27 June 2017

Hiroto Komano

1

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27 June 2017

Hirohisa Shiraishi

2

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27 June 2017

Yuuki Kawamura

3

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27 June 2017

Xiaorei Sai

4

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27 June 2017

Ryo Suzuki

5

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27 June 2017

Lutgarde Serneels

6

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27 June 2017

Masashi Kawaichi

7

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27 June 2017

Toshio Kitamura

8

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27 June 2017

Katsuhiko Yanagisawa

9

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27 June 2017

language of work or name

English

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publication date

2 August 2002

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Journal of Biological Chemistry

27 June 2017

7

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based on heuristic

inferred from page(s)

published in

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27 June 2017

277

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27 June 2017

39627-39633

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27 June 2017

42

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Amyloid beta-protein and the genetics of Alzheimer's disease

27 June 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

The Role of presenilins in gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Notch receptor cleavage depends on but is not directly executed by presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Efficient selection for high-expression transfectants with a novel eukaryotic vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Secretion of Alzheimer beta/A4 protein (1-40) and intracellular retention of beta/A4 protein (1-42) in transfected COS cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Amyloid precursor protein truncated at any of the gamma-secretase sites is not cleaved to beta-amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Neuronal expression of beta-amyloid precursor protein Alzheimer mutations causes intracellular accumulation of a C-terminal fragment containing both the amyloid beta and cytoplasmic domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Dominant effector genetics in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Efficient screening of retroviral cDNA expression libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer's beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Overexpression of Rab11 or constitutively active Rab11 does not affect sAPPalpha and Abeta secretions by wild-type and Swedish mutated betaAPP-expressing HEK293 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Rab1a and multiple other Rab proteins are associated with the transcytotic pathway in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Rab GTPases in vesicular transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Long amyloid beta-protein secreted from wild-type human neuroblastoma IMR-32 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

Intracellular site of gamma-secretase cleavage for Abeta42 generation in neuro 2a cells harbouring a presenilin 1 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205255200

21 January 2018

Identifiers

DOI

10.1074/JBC.M205255200

1 reference

27 June 2017

1 reference