PAK as a therapeutic target in gastric cancer (Q28272877)

Expert Opinion on Therapeutic Targets

Europe PubMed Central

title

PAK as a therapeutic target in gastric cancer (English)

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author name string

Xiaodong Li

series ordinal

1

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Funan Liu

series ordinal

2

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Feng Li

series ordinal

3

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language of work or name

English

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publication date

April 2010

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published in

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volume

14

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issue

4

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page(s)

419-33

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cites work

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Role of symptoms in diagnosis and outcome of gastric cancer.

21 January 2018

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A brain serine/threonine protein kinase activated by Cdc42 and Rac1

21 January 2018

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Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

21 January 2018

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p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts

21 January 2018

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p21-activated kinases: three more join the Pak.

21 January 2018

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Biology of the p21-activated kinases

21 January 2018

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A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases

21 January 2018

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Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728221003642019

Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728221003642019

Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728221003642019

Vascular endothelial growth factor up-regulation via p21-activated kinase-1 signaling regulates heregulin-beta1-mediated angiogenesis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728221003642019

Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728221003642019

Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728221003642019

Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728221003642019

Regulation of yeast protein kinase C activity by interaction with the small GTPase Rho1p through its amino-terminal HR1 domain

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728221003642019

Identification and molecular cloning of a p21cdc42/rac1-activated serine/threonine kinase that is rapidly activated by thrombin in platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Insulin activates a p21-activated kinase in muscle cells via phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

The Akt proto-oncogene links Ras to Pak and cell survival signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Interaction of a G-protein beta-subunit with a conserved sequence in Ste20/PAK family protein kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Structure of Cdc42 bound to the GTPase binding domain of PAK

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Identification of an autoinhibitory domain of p21-activated protein kinase 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Multiple Rho proteins regulate the subcellular targeting of PAK5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Crystal Structures of the p21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II PAKs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Negative control of the Myc protein by the stress-responsive kinase Pak2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Downregulation of p21-activated kinase-1 inhibits the growth of gastric cancer cells involving cyclin B1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Involvement of G proteins of the Rho family in the regulation of Bcl-2-like protein expression and caspase 3 activation by Gastrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Interaction between the Helicobacter pylori CagA and alpha-Pix in gastric epithelial AGS cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori lipopolysaccharide-stimulated macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

p21-activated Kinase-1 Signaling Mediates Cyclin D1 Expression in Mammary Epithelial and Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

The pak4 protein kinase plays a key role in cell survival and tumorigenesis in athymic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

The Drosophila p21-activated kinase Mbt modulates DE-cadherin-mediated cell adhesion by phosphorylation of Armadillo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Knockdown of p21-activated kinase 6 inhibits prostate cancer growth and enhances chemosensitivity to docetaxel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

p21 activated kinase 5 activates Raf-1 and targets it to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

MEK kinase activity is not necessary for Raf-1 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

p21-activated protein kinase gamma-PAK suppresses programmed cell death of BALB3T3 fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

PAK4 functions in tumor necrosis factor (TNF) alpha-induced survival pathways by facilitating TRADD binding to the TNF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

p21-activated protein kinase 4 (PAK4) interacts with the keratinocyte growth factor receptor and participates in keratinocyte growth factor-mediated inhibition of oxidant-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Correlation of Snail expression with histological grade and lymph node status in breast carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Pictures in cell biology. Pak1 kinase activity affects the character of cell morphology and movement

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Specificity profiling of Pak kinases allows identification of novel phosphorylation sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Calcium-independent contraction and sensitization of airway smooth muscle by p21-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Different molecular mechanisms for Rho family GTPase-dependent, Ca2+-independent contraction of smooth muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Phosphorylation of CPI17 and myosin binding subunit of type 1 protein phosphatase by p21-activated kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Inhibition of myosin light chain kinase by p21-activated kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Phosphorylation of myosin light chain kinase by p21-activated kinase PAK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

PAK1 negatively regulates the activity of the Rho exchange factor NET1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Phosphorylation and reorganization of vimentin by p21-activated kinase (PAK)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

A Rac-cGMP signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

PAK4 mediates morphological changes through the regulation of GEF-H1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

DGCR6L, a novel PAK4 interaction protein, regulates PAK4-mediated migration of human gastric cancer cell via LIMK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Podosome-type adhesions and focal adhesions, so alike yet so different

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Changes in the balance between caldesmon regulated by p21-activated kinases and the Arp2/3 complex govern podosome formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

A phase II study of G17DT in gastric carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Antiproliferative effect of a novel cholecystokinin-B/gastrin receptor antagonist, YM022.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

p21-Activated Kinase 2 in Neutrophils Can Be Regulated by Phosphorylation at Multiple Sites and by a Variety of Protein Phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Regulation of the p21-activated kinase (PAK) by a human Gbeta -like WD-repeat protein, hPIP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Merlin, the Product of the Nf2 Tumor Suppressor Gene, Is an Inhibitor of the p21-Activated Kinase, Pak1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

CRIPak, a novel endogenous Pak1 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively block the growth of RAS transformants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a celecoxib derivative, directly targets p21-activated kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Curcumin suppresses proliferation and invasion in human gastric cancer cells by downregulation of PAK1 activity and cyclin D1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Pak-1 expression increases with progression of colorectal carcinomas to metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Colorectal cancer: mutations in a signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

P21-activated kinase 5 is overexpressed during colorectal cancer progression and regulates colorectal carcinoma cell adhesion and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

High-resolution genomic and expression profiling reveals 105 putative amplification target genes in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Copy number alterations in pancreatic cancer identify recurrent PAK4 amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Estrogen receptor activation at serine 305 is sufficient to upregulate cyclin D1 in breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Identification of PAK4 as a putative target gene for amplification within 19q13.12-q13.2 in oral squamous-cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Regulation of Xenopus p21-activated kinase (X-PAK2) by Cdc42 and maturation-promoting factor controls Xenopus oocyte maturation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF- B-dependent resistance to apoptosis in 3D mammary acini

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003642019