Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1 (Q28219213)

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Liana Adam

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Diep Nguyen

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Yasutaka Ohta

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Thomas P Stossel

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Rakesh Kumar

Rho GTPases and the actin cytoskeleton

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language of work or name

English

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publication date

September 2002

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published in

Nature Cell Biology

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volume

4

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issue

9

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page(s)

681-90

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cites work

1 reference

7 January 2021

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

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7 January 2021

The GTPase-activating protein n-chimaerin cooperates with Rac1 and Cdc42Hs to induce the formation of lamellipodia and filopodia

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7 January 2021

Rho GTPases and their effector proteins

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A brain serine/threonine protein kinase activated by Cdc42 and Rac1

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Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

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7 January 2021

p21-activated protein kinase: a crucial component of morphological signaling?

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7 January 2021

A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.

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7 January 2021

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

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7 January 2021

Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells

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7 January 2021

Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling

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7 January 2021

Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation

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7 January 2021

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

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7 January 2021

Filamins as integrators of cell mechanics and signalling

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7 January 2021

Phosphorylation of actin-binding protein 280 by growth factors is mediated by p90 ribosomal protein S6 kinase

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7 January 2021

Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring

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7 January 2021

Actin-binding and dimerization domains of HeLa cell filamin

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7 January 2021

Actin-binding protein requirement for cortical stability and efficient locomotion

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7 January 2021

Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia.

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7 January 2021

Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1

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7 January 2021

Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase

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7 January 2021

Regulatable Expression of p21-activated Kinase-1 Promotes Anchorage-independent Growth and Abnormal Organization of Mitotic Spindles in Human Epithelial Breast Cancer Cells

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7 January 2021

A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids.

1 reference

7 January 2021

Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells

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7 January 2021

rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells

1 reference

7 January 2021

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7 January 2021

Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1

1 reference

7 January 2021

Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells

1 reference

7 January 2021

Identification of filamin as a novel ligand for caveolin-1: evidence for the organization of caveolin-1-associated membrane domains by the actin cytoskeleton

1 reference

7 January 2021

PAK2 is cleaved and activated during hyperosmotic shock-induced apoptosis via a caspase-dependent mechanism: Evidence for the involvement of oxidative stress

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7 January 2021

The small GTPase RalA targets filamin to induce filopodia

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7 January 2021

Temporal and spatial distribution of activated Pak1 in fibroblasts

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7 January 2021

A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm

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7 January 2021

Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor

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7 January 2021