K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK. (Q40696136)

22 September 2017

K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK. (English)

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22 September 2017

1

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22 September 2017

Geneviève Dorval

2

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22 September 2017

Mathieu Boudreau

3

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22 September 2017

Alexandre Angers-Loustau

4

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22 September 2017

Stephen J Morris

5

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22 September 2017

Joe Makkerh

6

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22 September 2017

Philip A Barker

7

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22 September 2017

language of work or name

English

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publication date

17 October 2002

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Journal of Biological Chemistry

22 September 2017

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22 September 2017

277

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22 September 2017

49473-49480

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22 September 2017

51

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Regressive events in neurogenesis.

22 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.M203428200

Programmed cell death and the control of cell survival: lessons from the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

Anti-apoptosis therapy: a way of treating neural degeneration?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

Regulation of neuronal survival by the serine-threonine protein kinase Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M203428200

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

The Akt proto-oncogene links Ras to Pak and cell survival signals

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M203428200

Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

The TrkB-Shc site signals neuronal survival and local axon growth via MEK and P13-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

Distinct neurite outgrowth signaling pathways converge on ERK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

CEP-1347/KT7515, a JNK pathway inhibitor, supports the in vitro survival of chick embryonic neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

Inhibition of aberrant and constitutive phosphorylation of the high-molecular-mass neurofilament subunit by CEP-1347 (KT7515), an inhibitor of the stress-activated protein kinase signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

Differential effects of the protein kinase inhibitor K-252a on the in vitro survival of chick embryonic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

Early induction of Talpha1 alpha-tubulin transcription in neurons of the developing nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

Concentration-dependent regulation of neuronal gene expression by nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

A simplified system for generating recombinant adenoviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

Identification of in vivo phosphorylation sites of MLK3 by mass spectrometry and phosphopeptide mapping

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

Adhesion-linked kinases in cancer; emphasis on src, focal adhesion kinase and PI 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

BAX is required for neuronal death after trophic factor deprivation and during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

Kinetics of trkA tyrosine kinase activity and inhibition by K-252a

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

Neuronal cell death: an updated view.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

Staurosporine-induced neurite outgrowth in PC12h cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

K-252a and staurosporine promote choline acetyltransferase activity in rat spinal cord cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

K-252a induces tyrosine phosphorylation of the focal adhesion kinase and neurite outgrowth in human neuroblastoma SH-SY5Y cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203428200

21 January 2018

Identifiers

DOI

10.1074/JBC.M203428200

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22 September 2017

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