Merlin, the Product of the Nf2 Tumor Suppressor Gene, Is an Inhibitor of the p21-Activated Kinase, Pak1 (Q28513718)

25 January 2017

title

Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1 (English)

1 reference

25 January 2017

Merlin, the Product of the Nf2 Tumor Suppressor Gene, Is an Inhibitor of the p21-Activated Kinase, Pak1 (English)

1 reference

https://api.crossref.org/works/10.1016/S1097-2765(03)00382-4

Non-catalytic region of tyrosine kinase adaptor protein 1

25 March 2024

main subject

cell line

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1 reference

Neurofibromin 2

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Rac family small GTPase 1

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Serine/threonine-protein kinase PAK 1

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Protein phosphatase 1 catalytic subunit alpha

1 reference

1 reference

https://api.crossref.org/works/10.1016/S1097-2765(03)00382-4

25 March 2024

author name string

Joseph L. Kissil

1

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25 January 2017

Erik W. Wilker

2

1 reference

25 January 2017

Kristen C. Johnson

3

1 reference

25 January 2017

Matthew S. Eckman

4

1 reference

25 January 2017

Michael B. Yaffe

5

1 reference

25 January 2017

Tyler Jacks

6

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25 January 2017

publication date

1 October 2003

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25 January 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14580336

http://www.cell.com/article/S1097276503003824/pdf

25 March 2024

work available at URL

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14580336

https://api.elsevier.com/content/article/PII:S1097276503003824?httpAccept=text/xml

25 March 2024

1 reference

https://api.crossref.org/works/10.1016/S1097-2765(03)00382-4

https://api.elsevier.com/content/article/PII:S1097276503003824?httpAccept=text/plain

25 March 2024

1 reference

https://api.crossref.org/works/10.1016/S1097-2765(03)00382-4

25 March 2024

1 reference

25 January 2017

volume

12

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25 January 2017

issue

4

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25 January 2017

page(s)

841–849

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describes a project that uses

25 January 2017

0 references

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Conformational switch and role of phosphorylation in PAK activation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Membrane targeting of p21-activated kinase 1(PAK1) induces neurite outgrowth from PC12 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Rho proteins induce metastatic properties in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Phosphorylation of Raf-1 Serine 338-Serine 339 Is an Essential Regulatory Event for Ras-Dependent Activation and Biological Signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Rho family proteins in cell adhesion and cell migration.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Role of cell shape in growth control

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Increased spreading, Rac/p21-activated kinase (PAK) activity, and compromised cell motility in cells deficient in vasodilator-stimulated phosphoprotein (VASP)

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Neurofibromatosis 2 tumor suppressor protein, merlin, forms two functionally important intramolecular associations

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Interaction of paxillin with p21-activated Kinase (PAK). Association of paxillin alpha with the kinase-inactive and the Cdc42-activated forms of PAK3.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Cell adhesion regulates the interaction between Nck and p21-activated kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

p21-activated kinases: three more join the Pak.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Merlin Phosphorylation by p21-activated Kinase 2 and Effects of Phosphorylation on Merlin Localization

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Function of the Rho family GTPases in Ras-stimulated Raf activation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

The Ras superfamily of GTPases.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Expression level, subcellular distribution and rho-GDI binding affinity of merlin in comparison with Ezrin/Radixin/Moesin proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

PAK Kinases Are Directly Coupled to the PIX Family of Nucleotide Exchange Factors

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

An essential role for Rac in Ras transformation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

The small GTPases Cdc42Hs, Rac1 and RhoG delineate Raf-independent pathways that cooperate to transform NIH3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Regulation of the Neurofibromatosis Type 2 Tumor Suppressor Protein, Merlin, by Adhesion and Growth Arrest Stimuli

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Cell cycle-regulated phosphorylation of p21-activated kinase 1.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

p21-activated kinase links Rac/Cdc42 signaling to merlin

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900382-4

7 January 2021

Identifiers

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017