Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch (Q27626911)

2

0 references

W Meng

3

0 references

M C Parrini

4

0 references

M J Eck

5

0 references

B J Mayer

6

0 references

S C Harrison

Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein

7

0 references

language of work or name

English

0 references

publication date

4 August 2000

0 references

published in

Cell

0 references

volume

102

0 references

page(s)

387-97

0 references

issue

3

0 references

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

1 reference

7 January 2021

Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

A novel regulator of p21-activated kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Interaction of the Nck adapter protein with p21-activated kinase (PAK1)

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

p21-activated kinase has substrate specificity similar to Acanthamoeba myosin I heavy chain kinase and activates Acanthamoeba myosin I

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Myosin I heavy chain kinase: cloning of the full-length gene and acidic lipid-dependent activation by Rac and Cdc42.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

HIV-1: is Nef a PAK animal?

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

p21-activated protein kinase: a crucial component of morphological signaling?

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

alphaPix stimulates p21-activated kinase activity through exchange factor-dependent and -independent mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Crystal structure of cyclin-dependent kinase 2

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

p21-activated kinase 1 plays a critical role in cellular activation by Nef.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Structure of the complex of Cdc42Hs with a peptide derived from P-21 activated kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Active and inactive protein kinases: structural basis for regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

The p21Rac/Cdc42-activated kinases (PAKs).

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Interaction of a G-protein beta-subunit with a conserved sequence in Ste20/PAK family protein kinases.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Mechanism of activation of Pak1 kinase by membrane localization

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Raster3D Version 2.0. A program for photorealistic molecular graphics

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Structure of Cdc42 bound to the GTPase binding domain of PAK

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Identification of the Nef-associated kinase as p21-activated kinase 2

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

The Cdc42/Rac interactive binding region motif of the Wiskott Aldrich syndrome protein (WASP) is necessary but not sufficient for tight binding to Cdc42 and structure formation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Inhibition of myosin light chain kinase by p21-activated kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Emerging from the Pak: the p21-activated protein kinase family.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Different requirements for formation of Jun: Jun and Jun: Fos complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Delineation of the Cdc42/Rac-binding domain of p21-activated kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Genetic evidence for Pak1 autoinhibition and its release by Cdc42.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Crystal structures of c-Src reveal features of its autoinhibitory mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Cloning and characterization of a novel Cdc42-associated tyrosine kinase, ACK-2, from bovine brain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900043-X

7 January 2021

10.1016/S0092-8674(00)00043-X

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1994374

1994374

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference