The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity (Q28118693)

4 January 2017

title

The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity (English)

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P21 (RAC1) activated kinase 2

4 January 2017

main subject

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P21 (RAC1) activated kinase 1

GOA release 2020-03-11

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protein serine/threonine kinase activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

C. Chong

1

1 reference

4 January 2017

L. Tan

2

1 reference

4 January 2017

L. Lim

3

1 reference

4 January 2017

E. Manser

4

1 reference

4 January 2017

language of work or name

English

0 references

publication date

18 May 2001

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Journal of Biological Chemistry

4 January 2017

published in

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4 January 2017

volume

276

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4 January 2017

issue

20

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4 January 2017

page(s)

17347–17353

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A brain serine/threonine protein kinase activated by Cdc42 and Rac1

4 January 2017

cites work

1 reference

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21 January 2018

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Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways

21 January 2018

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The p21Rac/Cdc42-activated kinases (PAKs).

21 January 2018

1 reference

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A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures

21 January 2018

1 reference

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PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

21 January 2018

1 reference

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A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.

21 January 2018

1 reference

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Genetic evidence for Pak1 autoinhibition and its release by Cdc42.

21 January 2018

1 reference

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Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

21 January 2018

1 reference

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Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

21 January 2018

1 reference

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Inhibition of myosin light chain kinase by p21-activated kinase

21 January 2018

1 reference

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p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts

21 January 2018

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PAK promotes morphological changes by acting upstream of Rac.

21 January 2018

1 reference

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PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

21 January 2018

1 reference

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alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase

21 January 2018

1 reference

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The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

21 January 2018

1 reference

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Molecular cloning and sequencing of the cytostatic G protein-activated protein kinase PAK I.

21 January 2018

1 reference

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Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation

21 January 2018

1 reference

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Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation

21 January 2018

1 reference

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Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity

21 January 2018

1 reference

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A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids.

21 January 2018

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Structure of Cdc42 bound to the GTPase binding domain of PAK

21 January 2018

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Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity

21 January 2018

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Determinants for substrate phosphorylation by p21-activated protein kinase (gamma-PAK).

21 January 2018

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A novel regulator of p21-activated kinases

21 January 2018

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p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).

21 January 2018

1 reference

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Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK.

21 January 2018

1 reference

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Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly

21 January 2018

1 reference

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Integrin-mediated signals regulated by members of the rho family of GTPases

21 January 2018

1 reference

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Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila

21 January 2018

1 reference

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Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila

21 January 2018

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A role for p21-activated kinase in endothelial cell migration.

21 January 2018

1 reference

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Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization

21 January 2018

1 reference

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Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M009316200

1 reference

Consolidated OpenCitations Corpus – April 2017

release_y2yzj6tobrck7cw5sleysniknu

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/y2yzj6tobrck7cw5sleysniknu

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017