Multiple functions of insulin-degrading enzyme: a metabolic crosslight? (Q50932512)

25 March 2018

review article

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title

Multiple functions of insulin-degrading enzyme: a metabolic crosslight? (English)

1 reference

25 March 2018

author

Giuseppe Grasso

4

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25 March 2018

author name string

Grazia R Tundo

1

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25 March 2018

Diego Sbardella

2

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25 March 2018

Chiara Ciaccio

3

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25 March 2018

Magda Gioia

5

1 reference

25 March 2018

Andrea Coletta

6

1 reference

25 March 2018

Fabio Polticelli

7

1 reference

25 March 2018

Donato Di Pierro

8

1 reference

25 March 2018

Danilo Milardi

9

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25 March 2018

Peter Van Endert

10

1 reference

25 March 2018

Stefano Marini

11

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25 March 2018

Massimo Coletta

12

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25 March 2018

publication date

21 June 2017

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25 March 2018

Critical Reviews in Biochemistry and Molecular Biology

published in

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25 March 2018

volume

52

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25 March 2018

page(s)

554-582

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25 March 2018

issue

5

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25 March 2018

Deletion of insulin-degrading enzyme elicits antipodal, age-dependent effects on glucose and insulin tolerance

cites work

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin and insulin-like growth factor receptors in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

The proteasome: structure, function, and role in the cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Oxidative stress-mediated regulation of proteasome complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Mapping the interactions between the Alzheimer's Aβ-peptide and human serum albumin beyond domain resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Inorganic stressors of ubiquitin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

The cryptome: a subset of the proteome, comprising cryptic peptides with distinct bioactivities

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Degradation of the cleaved leader peptide of thiolase by a peroxisomal proteinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

An unusual active site identified in a family of zinc metalloendopeptidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin inhibition of the proteasome is dependent on degradation of insulin by insulin-degrading enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Getting to first base in proteasome assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Deletion of the fission yeast homologue of human insulinase reveals a TORC1-dependent pathway mediating resistance to proteotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Risk of dementia in diabetes mellitus: a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Conservation in the Mechanism of Nedd8 Activation by the Human AppBp1-Uba3 Heterodimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Cellular distribution of insulin-degrading enzyme gene expression. Comparison with insulin and insulin-like growth factor receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Natural history of the E1-like superfamily: implication for adenylation, sulfur transfer, and ubiquitin conjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Alzheimer disease and vascular dementia: relationships with fasting glucose and insulin levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Protein misfolding, functional amyloid, and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Nitric oxide inhibits insulin-degrading enzyme activity and function through S-nitrosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin-degrading enzyme inhibition, a novel therapy for type 2 diabetes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Structure and functions of the 20S and 26S proteasomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Therapeutic treatments for Alzheimer's disease based on metal bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Chaperone-mediated autophagy: roles in disease and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

No major role for insulin-degrading enzyme in antigen presentation by MHC molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Identification of radioactive insulin fragments liberated by insulin proteinase during the degradation of semisynthetic [3H]GlyA1]insulin and [3H]PheB1]insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Identification of some cleavage sites of insulin by insulin proteinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Degradation of oxidized proteins by the 20S proteasome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Alzheimer's disease is type 3 diabetes-evidence reviewed

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Proteolytically inactive insulin-degrading enzyme inhibits amyloid formation yielding non-neurotoxic aβ peptide aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

The irreversible binding of amyloid peptide substrates to insulin-degrading enzyme: a biological perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Ubiquitin-binding domains - from structures to functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin degradation: mechanisms, products, and significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin and Glucagon Degradation by the Same Enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin degradation: progress and potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Structural insights into proteasome activation by the 19S regulatory particle

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Stem cell antigen-1 localizes to lipid microdomains and associates with insulin degrading enzyme in skeletal myoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Subcellular distribution and dynamics of active proteasome complexes unraveled by a workflow combining in vivo complex cross-linking and quantitative proteomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Label-free quantitative proteomics reveals the dynamics of proteasome complexes composition and stoichiometry in a wide range of human cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Purification of a protease in red blood cells that degrades oxidatively damaged haemoglobin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Degradation of insulin by isolated rat renal cortical endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin-degrading enzyme: structure-function relationship and its possible roles in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Role of proteasomes in the degradation of short-lived proteins in human fibroblasts under various growth conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

The Drosophila insulin-degrading enzyme restricts growth by modulating the PI3K pathway in a cell-autonomous manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Moonlighting proteins in yeasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Regulation of Insulin, Epidermal Growth Factor, and Transforming Growth Factor-α Levels by Growth Factor-Degrading Enzymes*

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Functional relevance of a novel SlyX motif in non-conventional secretion of insulin-degrading enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Functional analysis of the proteasome regulatory particle

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Degradation of insulin by isolated mouse pancreatic acini. Evidence for cell surface protease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Monitoring the biomolecular interactions and the activity of Zn-containing enzymes involved in conformational diseases: experimental methods for therapeutic purposes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Metal complexes and metalloproteases: targeting conformational diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Enzyme solid-state support assays: a surface plasmon resonance and mass spectrometry coupled study of immobilized insulin degrading enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Copper(I) and copper(II) inhibit Aβ peptides proteolysis by insulin-degrading enzyme differently: implications for metallostasis alteration in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Metal ions affect insulin-degrading enzyme activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Metabolism of cryptic peptides derived from neuropeptide FF precursors: the involvement of insulin-degrading enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Metallostasis and amyloid β-degrading enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

AP/MALDI-MS complete characterization of the proteolytic fragments produced by the interaction of insulin degrading enzyme with bovine insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

How the binding and degrading capabilities of insulin degrading enzyme are affected by ubiquitin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

The proteolytic activity of insulin-degrading enzyme: a mass spectrometry study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin-degrading enzyme: a link between Alzheimer's and type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

The insulysin (insulin degrading enzyme) enigma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Lingering mysteries of ubiquitin-chain assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Moonlighting proteins: an intriguing mode of multitasking

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Structure, function, and regulation of insulin-degrading enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Increased risk of type 2 diabetes in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

21 January 2018

Moonlighting proteins.

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Molecular mechanisms for multitasking: recent crystal structures of moonlighting proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Impact of Insulin Degrading Enzyme and Neprilysin in Alzheimer's Disease Biology: Characterization of Putative Cognates for Therapeutic Applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Effects of ageing and experimental diabetes on insulin-degrading enzyme expression in male rat tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Risk of incident Alzheimer's disease in diabetic patients: a systematic review of prospective trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Truncated and modified amyloid-beta species

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Nitric oxide decreases the enzymatic activity of insulin degrading enzyme in APP/PS1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin-degrading enzyme is differentially expressed and developmentally regulated in various rat tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Amyloidogenic determinant as a substrate recognition motif of insulin-degrading enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin-degrading enzyme: embarking on amyloid destruction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

mTOR signaling in growth control and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Protein degradation by the ubiquitin-proteasome pathway in normal and disease states

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

The C-terminal domain of human insulin degrading enzyme is required for dimerization and substrate recognition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Promotion of amyloid beta protein misfolding and fibrillogenesis by a lipid oxidation product

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Targeting the phosphoinositide 3-kinase pathway in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Reversible 26S proteasome disassembly upon mitochondrial stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Hyperinsulinemia and risk of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme †

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading Enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Human serum albumin inhibits Abeta fibrillization through a "monomer-competitor" mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Abeta-degrading enzymes in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Aβ-degrading enzymes: potential for treatment of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Bifunctional and moonlighting enzymes: lighting the way to regulatory control

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Differential degradation of amyloid beta genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin-degrading enzyme degrades amyloid peptides associated with British and Danish familial dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin-degrading enzyme exists inside of rat liver peroxisomes and degrades oxidized proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Production of lipid peroxidation products in osteoarthritic tissues: new evidence linking 4-hydroxynonenal to cartilage degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Type 2 diabetes as a protein misfolding disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Atrial natriuretic peptide (ANP) is a high-affinity substrate for rat insulin-degrading enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Rat insulin-degrading enzyme: cleavage pattern of the natriuretic peptide hormones ANP, BNP, and CNP revealed by HPLC and mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Molecular mechanisms of proteasome assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Copper, differently from zinc, affects the conformation, oligomerization state and activity of bradykinin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

New Insights into Epigenetic and Pharmacological Regulation of Amyloid-Degrading Enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Amyloid-degrading enzymes as therapeutic targets in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Identification of the allosteric regulatory site of insulysin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Anion Activation Site of Insulin-degrading Enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin has multiple antiamyloidogenic effects on human neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Production of an antigenic peptide by insulin-degrading enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Polyubiquitin chains: polymeric protein signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Inhibition of the 26 S proteasome by polyubiquitin chains synthesized to have defined lengths

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Biological and chemical approaches to diseases of proteostasis deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Intracellular insulin in human tumors: examples and implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Retinoblastoma protein co-purifies with proteasomal insulin-degrading enzyme: implications for cell proliferation control

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Ubiquitin is a novel substrate for human insulin-degrading enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Diversity of degradation signals in the ubiquitin-proteasome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Degradation of oxidized proteins by the proteasome: Distinguishing between the 20S, 26S, and immunoproteasome proteolytic pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Hyperinsulinaemia and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Ubiquitin-mediated pathways for intracellular proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Intranasal insulin improves cognition and modulates beta-amyloid in early AD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Eclipsed distribution: a phenomenon of dual targeting of protein and its significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Comparative resistance of the 20S and 26S proteasome to oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Association between variants in IDE-KIF11-HHEX and plasma amyloid β levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Reduced insulin clearance and lower insulin-degrading enzyme expression in the liver might contribute to the thrifty phenotype of protein-restricted mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Identification of gamma-endorphin-generating enzyme as insulin-degrading enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Copper(II) ions affect the gating dynamics of the 20S proteasome: a molecular and in cell study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Enzymatic processing by MMP-2 and MMP-9 of wild-type and mutated mouse β-dystroglycan.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Proteasome Activity Is Affected by Fluctuations in Insulin-Degrading Enzyme Distribution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Unraveling Alzheimer's: Making Sense of the Relationship between Diabetes and Alzheimer's Disease1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

The ubiquitin-proteasome pathway and pathogenesis of human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Overexpression of insulin degrading enzyme: cellular localization and effects on insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Susceptibility of amyloid beta peptide degrading enzymes to oxidative damage: a potential Alzheimer's disease spiral

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin promotes rapid delivery of N-methyl-D- aspartate receptors to the cell surface by exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

An Extended Polyanion Activation Surface in Insulin Degrading Enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Substrate activation of insulin-degrading enzyme (insulysin). A potential target for drug development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

A monomeric variant of insulin degrading enzyme (IDE) loses its regulatory properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Mixed dimers of insulin-degrading enzyme reveal a cis activation mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Single-gene disorders: what role could moonlighting enzymes play?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

The type 2 diabetes-associated gene ide is required for insulin secretion and suppression of α-synuclein levels in β-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Transcriptome and proteome expressions involved in insulin resistance in muscle and activated T-lymphocytes of patients with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

The effect of insulin and insulin-like growth factors on hippocampus- and amygdala-dependent long-term memory formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin and cognitive function in an elderly population. The Rotterdam Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Differential effects of proteases involved in intracellular degradation of amyloid beta-protein between detergent-soluble and -insoluble pools in CHO-695 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Somatostatin modulates insulin-degrading-enzyme metabolism: implications for the regulation of microglia activity in AD

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin-degrading enzyme (IDE): a novel heat shock-like protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Novel Platinum(II) compounds modulate insulin-degrading enzyme activity and induce cell death in neuroblastoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Effect of cisplatin on proteasome activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Multiple allosteric sites are involved in the modulation of insulin-degrading-enzyme activity by somatostatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin clearance in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Structure of ubiquitin refined at 1.8 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

CALHM1 ion channel elicits amyloid-β clearance by insulin-degrading enzyme in cell lines and in vivo in the mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Association between polymorphisms of the insulin-degrading enzyme gene and late-onset Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Inhibition of Proteasome Activity Induces Formation of Alternative Proteasome Complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Regulation of insulin degrading enzyme activity by obesity-associated factors and pioglitazone in liver of diet-induced obese mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Molecular links between Alzheimer's disease and diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

The role of ubiquitin in autophagy-dependent protein aggregate processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

PTEN: a new guardian of the genome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Hyperinsulinemia and cognitive decline in a middle-aged cohort.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin-degrading enzyme is exported via an unconventional protein secretion pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Role of insulin and insulin receptor in learning and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

mTOR: from growth signal integration to cancer, diabetes and ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

The insulin degrading enzyme activates ubiquitin and promotes the formation of K48 and K63 diubiquitin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

A neglected modulator of insulin-degrading enzyme activity and conformation: The pH

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Ubiquitin Stability and the Lys 63-Linked Polyubiquitination Site Are Compromised on Copper Binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insulin-degrading enzyme is activated by the C-terminus of α-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Insights into the Molecular Composition of Endogenous Unanchored Polyubiquitin Chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Regulation by insulin of a unique neuronal Ca2+ pool and of neuropeptide secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

Enzyme target to latch on to

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409238.2017.1337707

10.1080/10409238.2017.1337707

21 January 2018

Identifiers

DOI

1 reference

25 March 2018

PubMed ID

28635330

1 reference

25 March 2018