Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease (Q33526360)

27 July 2017

Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease (English)

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27 July 2017

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Igor Rudan

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Veronique Vitart

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Veronique Vitart

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Christopher M Watson

Christopher M Watson

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Stephen Todd

Stephen Todd

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Kevin Morgan

Kevin Morgan

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Patrick G. Kehoe

Patrick G Kehoe

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Clive Holmes

Clive Holmes

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Nilüfer Ertekin-Taner

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Nilufer Ertekin-Taner

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Ronald C Petersen

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Bernadette McGuinness

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Bernadette McGuinness

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Harry Campbell

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Nicholas D Hastie

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Morad Ansari

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Chloe M Stanton

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Noor Kalsheker

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Minerva M Carrasquillo

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Minerva M Carrasquillo

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Neill R Graff-Radford

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Neill R Graff-Radford

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Mariet Allen

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Fanggeng Zou

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Curtis S Younkin

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V Shane Pankratz

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Kristelle Brown

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Samantha L Wilcox

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Samuel G Younkin

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Linda H Younkin

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Chanley C Howell

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Alan F Wright

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Steven G Younkin

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Olivia Belbin

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Olivia Belbin

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Mariah R Kashino

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Li Ma

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Toros A Dincman

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Melissa E Howard

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Michael Crump

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Peter Passmore

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David Craig

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David M Mann

32

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A David Smith

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Helen Beaumont

34

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Donald Warden

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Reinhard Heun

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Heike Kölsch

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27 July 2017

language of work or name

English

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publication date

19 January 2010

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27 July 2017

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5

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e8764

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1

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Creative Commons Attribution 4.0 International

27 July 2017

start time

19 January 2010

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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21 June 2018

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21 June 2018

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21 June 2018

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GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers

21 June 2018

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21 June 2018

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The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

21 June 2018

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21 June 2018

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Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis.

21 June 2018

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Mutation screening of a haplotype block around the insulin degrading enzyme gene and association with Alzheimer's disease

21 June 2018

1 reference

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Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.

21 June 2018

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Deciphering the molecular basis of memory failure in Alzheimer's disease

21 June 2018

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The current status of Alzheimer's disease genetics: what do we tell the patients?

21 June 2018

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21 June 2018

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Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease.

21 June 2018

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Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808243

Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease

21 June 2018

1 reference

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Genetic variation in a haplotype block spanningIDE influences Alzheimer disease

21 June 2018

1 reference

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Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo

21 June 2018

1 reference

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Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

21 June 2018

1 reference

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Results of a high-resolution genome screen of 437 Alzheimer's disease families

21 June 2018

1 reference

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Score tests for association between traits and haplotypes when linkage phase is ambiguous

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808243

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808243

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

21 June 2018

1 reference

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Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

21 June 2018

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Heritability for Alzheimer's disease: the study of dementia in Swedish twins

21 June 2018

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 June 2018

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Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

21 June 2018

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

21 June 2018

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Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

21 June 2018

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An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 June 2018

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Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

21 June 2018

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Lack of association of 5 SNPs in the vicinity of the insulin-degrading enzyme (IDE) gene with late-onset Alzheimer's disease.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808243

Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808243

Weak independent association signals between IDE polymorphisms, Alzheimer's disease and cognitive measures.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808243

Insulin degrading enzyme and alpha-3 catenin polymorphisms in Italian patients with Alzheimer disease.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808243

Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808243

Sequence variants of IDE are associated with the extent of beta-amyloid deposition in the Alzheimer's disease brain.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808243

Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808243

Insulin-degrading enzyme, apolipoprotein E, and Alzheimer's disease.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808243

No association between the insulin degrading enzyme gene and Alzheimer's disease in a Japanese population.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808243

Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: evidence of effect modification by apolipoprotein E (APOE).

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808243

Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808243

Confirmation of association between D10S583 and Alzheimer's disease in a case--control sample.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808243

Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808243

Case-control studies of genetic markers: power and sample size approximations for Armitage's test for trend.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808243

A full genome scan for late onset Alzheimer's disease.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808243

Effects of genome-wide heterozygosity on a range of biomedically relevant human quantitative traits

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808243

The role of heredity in late-onset Alzheimer disease and vascular dementia. A twin study

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20098734

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Evidence for genetic linkage of Alzheimer's disease to chromosome 10q

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20098734

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0008764

1 reference

27 July 2017

0 references

1 reference

27 July 2017

1 reference